Product Name : non-SMC condensin I complex, subunit HTarget gene : NCAPHverified_species_reactivity : Humaninterspecies_information : 80%, ENSMUSG00000034906, species_id: MOUSE, 82%, ENSRNOG00000012051, species_id: RATclonality : Polyclonalisotype : IgGhost : Rabbitbuffer :…
Product Name : EGFRTarget points: AlphamabStatus: Organization : ProteinShort name : Homo sapiensType: Organism: Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two…
Product Name : myosin IHTarget gene : MYO1Hverified_species_reactivity : Humaninterspecies_information : 72%, ENSMUSG00000066952, species_id: MOUSE, 72%, ENSRNOG00000047191, species_id: RATclonality : Polyclonalisotype : IgGhost : Rabbitbuffer : 40% glycerol and PBS…
Product Name : IL-1RAPTarget points: Boehringer IngelheimStatus: Organization : ProteinShort name : Homo sapiensType: Organism: Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of…
BCL-2 (B-cell Lymphoma 2) is a protein that regulates cell death via anti-apoptotic or pro-apoptotic activity. It has two isoforms, with the name of 1G5M (isform 1) and 1G5O/1GJH (isoform 2).…
Product Name : B7-H3Target points: University of PittsburghStatus: Organization : ProteinShort name : Homo sapiensType: Organism: Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist…
Product Name : GIPrTarget points: MedimmuneStatus: Organization : ProteinShort name : Homo sapiensType: Organism: Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two…
CREB (cAMP response element-binding protein) is a cellular transcription factor. It activates transcription by binding to CBP (CREB-binding protein) domains. CREB interacts with CPB involving kinase-inducible domain (KID) from CREB and…
Product Name : mPEG16-BrFull Name: mPEG16-BrSynonyms : mPEG16-BrCAS:1238189-11-1Molecular formula : C33H67O16BrMolecular Weight: 799.2763252-25-9 web 78Appearance: White Solid or Colorless LiquidStorage: -18℃ for long term storage1523164-68-2 Biological Activity PMID:20437616 MedChemExpress (MCE)…
Product Name : CD4Target points: Kyowa Hakko KirinStatus: CD4Organization : ProteinShort name : Homo sapiensType: Organism: Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist…
Product Name : (+)-Biotin-PEG9-CH2CH2COOHFull Name: (+)-Biotin-PEG9-CH2CH2COOHSynonyms : (+)-Biotin-PEG9-CH2CH2COOHCAS:Molecular formula : C27H49N3SO11Molecular Weight: 623.42464-96-0 supplier 76Appearance: White PowderStorage: -18℃ for long term storage, avoid light142880-36-2 Purity & Documentation PMID:29369572 MedChemExpress (MCE)…
Product Name : Alpha-synucleinTarget points: DenaliStatus: Alpha-synucleinOrganization : ProteinShort name : Homo sapiensType: Organism: Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two…
Product Name : ABCB1 Monoclonal Antibody (OTI10H3), TrueMAB™Species Reactivity: HumanHost/Isotype : Mouse / IgG2bClass:MonoclonalType : AntibodyClone: OTI10H3Conjugate : UnconjugatedForm: lyophilizedConcentration : 1 mg/mLPurification : Affinity chromatographyStorage buffer: PBS, pH 7.3,…
Product Name : HER2/neuTarget points: BIOCNDGenor BiopharmaStatus: Organization : ProteinShort name : Homo sapiensType: Organism: Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of…
Product Name : Rabbit anti-YTHD2 Polyclonal Antibody(C-term)Synonym : YTH domain-containing family protein 2; CLL-associated antigen KW-14; High-glucose-regulated protein 8; Renal carcinoma antigen NY-REN-2; YTHDF2; HGRG8Host : RabbitSpecies Reactivity: HumanSpecificity :…
Product Name : UndisclosedTarget points: AtrecaZymeworksStatus: Organization : Short name : Type: Organism: Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light…
Product Name : Rabbit anti-TLR4 Polyclonal AntibodySynonym : TLR4; TLR-4; TLR 4; ARMD10; CD 284; CD284; CD284 antigen; Homolog of Drosophila toll; hTol; Toll (Drosophila) homolog; TOLL; Toll Endotoxin Hyporesponsiveness;…
Product Name : BCMATarget points: EngmabStatus: Organization : ProteinShort name : Homo sapiensType: Organism: Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two…
Product Name : Rabbit anti-RPP30 Polyclonal AntibodySynonym : TSG15Host : RabbitSpecies Reactivity: Human, Mouse, RatSpecificity : Predicted Reactivity: Applications : WB 1:500 - 1:2000IHC 1:50 - 1:200IF 1:50 - 1:200Immunogen:…
Product Name : MIC-1Target points: Chinese Academy of Medical Sciences, Peking Union MedicalStatus: Organization : ProteinShort name : Homo sapiensType: Organism: Antibodies are immunoglobulins secreted by effector lymphoid B cells…
Product Name : Rabbit anti-PAK2 Polyclonal AntibodySynonym : PAK65; PAKgammaHost : RabbitSpecies Reactivity: Human, Mouse, RatSpecificity : Predicted Reactivity: Applications : WB 1:500 - 1:2000IHC 1:50 - 1:200IF 1:50 -…
Product Name : B7-H3Target points: MabwellStatus: Organization : ProteinShort name : Homo sapiensType: Organism: Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two…
Product Name : Rabbit anti-JADE1 Polyclonal AntibodySynonym : PHF17Host : RabbitSpecies Reactivity: Human, MouseSpecificity : Predicted Reactivity: Applications : IHC 1:50 - 1:100IF 1:50 - 1:100Immunogen: Recombinant fusion protein containing…
Product Name : MFSD2ATarget points: HarvardStatus: Organization : ProteinShort name : Homo sapiensType: Organism: Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two…
Product Name : Rabbit anti-Cortactin Polyclonal AntibodySynonym : EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1Host : RabbitSpecies Reactivity: Human, Mouse, RatSpecificity : Recognizes endogenous levels of Cortactin protein.Predicted Reactivity: Applications…
Product Name : CEACAM1Target points: DiathevaAgenusStatus: Organization : ProteinShort name : Homo sapiensType: Organism: Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two…
Product Name : Rabbit anti-CREB3L1 Polyclonal Antibody(C-term)Synonym : Cyclic AMP-responsive element-binding protein 3-like protein 1; cAMP-responsive element-binding protein 3-like protein 1; Old astrocyte specifically-induced substance; OASIS; Processed cyclic AMP-responsive element-binding…
Product Name : Nogo receptor-1Target points: AbbvieStatus: Nogo receptor-1Organization : ProteinShort name : Homo sapiensType: Organism: Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist…
Product Name : Rabbit anti-ATAD3C Polyclonal Antibody(Center)Synonym : ATPase family AAA domain-containing protein 3C; ATAD3CHost : RabbitSpecies Reactivity: HumanSpecificity : This ATAD3C antibody is generated from rabbits immunized with a…
Product Name : FcRnTarget points: UCBStatus: Organization : ProteinShort name : Homo sapiensType: Organism: Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two…
Product Name : Rabbit anti-STAT1 Polyclonal AntibodySynonym : signal transducers and activators of transcription 1; DKFZp686B04100; ISGF 3; ISGF-3; Signal transducer and activator of transcription 1 91kDa; Signal transducer and…
Product Name : CD7Target points: Nanjing BiohengStatus: CD7Organization : ProteinShort name : Homo sapiensType: Organism: Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of…
Product Name : Annexin VI Polyclonal Antibody, Cyanine5.5Species Reactivity: Human, MouseHost/Isotype : Rabbit / IgGClass:PolyclonalType : AntibodyClone: Conjugate : Cyanine5.5Form: LiquidConcentration : 1 mg/mLPurification : Protein AStorage buffer: TBS with…
Product Name : CasticinDescription:Casticin is a methyoxylated flavonol isolated from Viticis Fructus, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3.CAS: 479-91-4Molecular Weight:374.34Formula: C19H18O8Chemical Name: 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxy-4H-chromen-4-oneSmiles : COC1C=C2OC(=C(OC)C(=O)C2=C(O)C=1OC)C1=CC(O)=C(C=C1)OCInChiKey:…
Product Name : Androgen Receptor Monoclonal Antibody (AR 441)Species Reactivity: HumanHost/Isotype : Mouse / IgG1, kappaClass:MonoclonalType : AntibodyClone: AR 441Conjugate : UnconjugatedForm: LiquidConcentration : 0.2 mg/mLPurification : Protein A/GStorage buffer:…
Product Name : XL041Description:XL041 (BMS-852927) is an LXRβ-selective agonist.CAS: 1256918-39-4Molecular Weight:609.51Formula: C29H28Cl2F2N2O4SChemical Name: 2-2--1--4-yl]-1H-imidazol-4-ylpropan-2-olSmiles : CC(C)(O)C1=CN(C(=N1)C(C)(C)C1C(Cl)=CC=CC=1Cl)C1=CC=C(C=C1F)C1C=C(F)C(CO)=C(C=1)S(C)(=O)=OInChiKey: HNAJDMYOTDNOBK-UHFFFAOYSA-NInChi : InChI=1S/C29H28Cl2F2N2O4S/c1-28(2,26-19(30)7-6-8-20(26)31)27-34-25(29(3,4)37)14-35(27)23-10-9-16(11-22(23)33)17-12-21(32)18(15-36)24(13-17)40(5,38)39/h6-14,36-37H,15H2,1-5H3Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under…
Product Name : Alpha-2-macroglobulin Monoclonal Antibody (B1-D7)Species Reactivity: HumanHost/Isotype : Mouse / IgG1Class:MonoclonalType : AntibodyClone: B1-D7Conjugate : UnconjugatedForm: LiquidConcentration : 2 mg/mLPurification : Protein AStorage buffer: PBS, pH 7.4, with…
Product Name : QCA570Description:QCA570 is a potent BET degrader based on PROTAC, with an IC50 of 10 nM for BRD4 BD1 Protein.CAS: 2207569-08-0Molecular Weight:695.79Formula: C39H33N7O4SChemical Name: 3-(4-5-trideca-2(6),4,10,12-tetraen-4-ylethynyl)-1H-pyrazol-1-yl]pent-1-yn-1-yl-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dioneSmiles : CC1=NN=C2COCC3=C(SC(C#CC4=CN(CCCC#CC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=C4)=C3CC3C=CC=CC=3)N21InChiKey: RTVTYLRQKKDYMQ-UHFFFAOYSA-NInChi…
Product Name : Aflatoxin Monoclonal Antibody (6A10), HRPSpecies Reactivity: ChemicalHost/Isotype : Mouse / IgG1, kappaClass:MonoclonalType : AntibodyClone: 6A10Conjugate : HRP View additional formats Biotin DyLight 488 DyLight 550 DyLight 650…
Product Name : Tilmicosin phosphateDescription:Tilmicosin phosphate is a antibiotic, is used for the research of bovine respiratory disease and ovine respiratory disease associated with Mannheimia (Pasteurella) haemolytica.CAS: 137330-13-3Molecular Weight:967.13Formula: C46H83N2O17PChemical…
Product Name : HO-PEG6-OHFull Name: Hexaethylene GlycolSynonyms : HO-PEG6-OHCAS:2615-15-8Molecular formula : C12H26O7Molecular Weight: 282.33Appearance: Colorless LiquidStorage: -18℃ for long term storage566939-85-3 Protocol 1338934-59-0 In Vitro PMID:31070878 MedChemExpress (MCE) offers a…
Product Name : Cholesteryl LinolenateDescription:Cholesteryl Linolenate is an endogenous metabolite.CAS: 2545-22-4Molecular Weight:647.07Formula: C45H74O2Chemical Name: (1R,3aS,3bS,7S,9aR,9bS,11aR)-9a,11a-dimethyl-1--1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopentaphenanthren-7-yl (9Z,12Z,15Z)-octadeca-9,12,15-trienoateSmiles : CC(C)CCC(C)1CC23CC=C4C(CC4(C)3CC12C)OC(=O)CCCCCCC/C=C\C/C=C\C/C=C\CCInChiKey: FYMCIBHUFSIWCE-WVXFKAQASA-NInChi : InChI=1S/C45H74O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h8-9,11-12,14-15,26,35-36,38-42H,7,10,13,16-25,27-34H2,1-6H3/b9-8-,12-11-,15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition:…
Product Name : AURKAIP1 Polyclonal AntibodySpecies Reactivity: HumanHost/Isotype : Rabbit / IgGClass:PolyclonalType : AntibodyClone: Conjugate : UnconjugatedForm: LiquidConcentration : 2.6 mg/mLPurification : Antigen affinity chromatographyStorage buffer: PBS, pH 7.4, with…
Product Name : Glutaminase C-IN-1Description:Glutaminase C-IN-1 (Compound 968) is an allosteric inhibitor of Glutaminase C that inhibits cancer cell growth without affecting their normal cellular counterparts.CAS: 311795-38-7Molecular Weight:475.42Formula: C27H27BrN2OChemical Name:…
Product Name : ATP2c1/2 Polyclonal AntibodySpecies Reactivity: Human, Mouse, RatHost/Isotype : Rabbit / IgGClass:PolyclonalType : AntibodyClone: Conjugate : UnconjugatedForm: LiquidConcentration : 1 mg/mLPurification : Protein AStorage buffer: PBS with 50%…
Product Name : Bay 41-4109 racemateDescription:BAY 41-4109 racemate is the racemate of BAY 41-4109. BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of…
Product Name : ATOH1 Monoclonal Antibody (2B7)Species Reactivity: HumanHost/Isotype : Mouse / IgG1, kappaClass:MonoclonalType : AntibodyClone: 2B7Conjugate : UnconjugatedForm: LiquidConcentration : See LabelPurification : Affinity chromatographyStorage buffer: PBS, pH 7.4Contains…
Product Name : AZD4205Description:AZD4205 is a selective JAK1 inhibitor, with an IC50 of 73 nM, weakly inhibits JAK2 (IC50>14.7 μM), and shows little inhibition on JAK3 (IC50>30 μM).CAS: 2091134-68-6Molecular Weight:489.57Formula:…
Product Name : ATG16L1 Polyclonal Antibody, BiotinSpecies Reactivity: Human, Mouse, RatHost/Isotype : Rabbit / IgGClass:PolyclonalType : AntibodyClone: Conjugate : BiotinForm: LiquidConcentration : 0.5-1.5 mg/mLPurification : Affinity chromatographyStorage buffer: proprietary buffer,…
Product Name : ML348Description:ML348 (GNF-Pf-1127) is a selective and reversible acyl-protein thioesterase 1 (APT1)/lysophospholipase 1 (LYPLA1) inhibitor with an IC50 of 210 nM, and barely inhibits LYPLA2.CAS: 899713-86-1Molecular Weight:415.79Formula: C18H17ClF3N3O3Chemical…
Product Name : ASS1 Monoclonal Antibody (OTI12G1)Species Reactivity: HumanHost/Isotype : Mouse / IgG1Class:MonoclonalType : AntibodyClone: OTI12G1Conjugate : UnconjugatedForm: LiquidConcentration : 1 mg/mLPurification : Affinity ChromatographyStorage buffer: PBS, pH 7.3, with…
Product Name : L-689502Description:L-689502 is a potent inhibitor of HIV-l protease with an IC50 of 1 nM.CAS: 138483-63-3Molecular Weight:673.84Formula: C39H51N3O7Chemical Name: tert-butyl N-carbamoyl-5-(4-phenylmethyl)-1-phenylpentan-2-yl]carbamateSmiles : CC(C)(C)OC(=O)N(CC1C=CC=CC=1)(O)C(CC1C=CC(=CC=1)OCCN1CCOCC1)C(=O)N1(O)CC2C=CC=CC=21InChiKey: IYLCQJSWFWQHCD-AIIVFDHXSA-NInChi : InChI=1S/C39H51N3O7/c1-39(2,3)49-38(46)40-33(24-27-9-5-4-6-10-27)34(43)26-30(37(45)41-36-32-12-8-7-11-29(32)25-35(36)44)23-28-13-15-31(16-14-28)48-22-19-42-17-20-47-21-18-42/h4-16,30,33-36,43-44H,17-26H2,1-3H3,(H,40,46)(H,41,45)/t30-,33+,34+,35-,36+/m1/s1Purity: ≥98% (or…
Product Name : ASB7 Polyclonal Antibody, MaxPab™Species Reactivity: HumanHost/Isotype : Mouse / IgGClass:PolyclonalType : AntibodyClone: Conjugate : UnconjugatedForm: LiquidConcentration : Purification : Protein AStorage buffer: PBS, pH 7.4Contains : no…
Product Name : Penitrem ADescription:Penitrem A is an indole diterpene neurotoxic alkaloid produced by Penicillium, acts as a selective BK channel antagonist with antiproliferative and anti-invasive activities against multiple malignancies.…
Product Name : ARID2 Monoclonal Antibody (GT7311)Species Reactivity: Human, MouseHost/Isotype : Mouse / IgG1Class:MonoclonalType : AntibodyClone: GT7311Conjugate : UnconjugatedForm: LiquidConcentration : 1 mg/mLPurification : Protein GStorage buffer: PBS, pH 7,…
Product Name : JNJ-54166060Description:JNJ-54166060 is a potent and selective P2X7 receptor antagonist, with IC50s of 4/115/72 nM for human/rat/mouse P2X7 receptor, respectively.CAS: 1627900-41-7Molecular Weight:438.81Formula: C20H15ClF4N4OChemical Name: 2--4-methyl-1H, 4H, 5H, 6H,…
Product Name : ARF1/ARF3/ARF5/ARF6 Monoclonal Antibody (1D9)Species Reactivity: Dog, Hamster, Human, Mouse, RatHost/Isotype : Mouse / IgG1Class:MonoclonalType : AntibodyClone: 1D9Conjugate : UnconjugatedForm: LiquidConcentration : Conc. Not DeterminedPurification : Storage buffer:…
Product Name : PROTAC BRD2/BRD4 degrader-1Description:PROTAC BRD2/BRD4 degrader-1 (compound 15) is a potent and selective BET protein BRD4 and BRD2 degrader. PROTAC BRD2/BRD4 degrader-1 rapidly induces reversible, long-lasting, and unexpectedly…
Product Name : APRT Polyclonal AntibodySpecies Reactivity: HumanHost/Isotype : Rabbit / IgGClass:PolyclonalType : AntibodyClone: Conjugate : UnconjugatedForm: LiquidConcentration : 0.19 mg/mLPurification : Antigen affinity chromatographyStorage buffer: PBS, pH 7.3, with…
Product Name : Quetiapine sulfoxide hydrochlorideDescription:Quetiapine sulfoxide hydrochloride (Quetiapine S-oxide hydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic. Quetiapine is a 5-HT receptors agonist and a…
Product Name : AMY2A Monoclonal Antibody (OTI1E3), TrueMAB™Species Reactivity: HumanHost/Isotype : Mouse / IgG2bClass:MonoclonalType : AntibodyClone: OTI1E3Conjugate : UnconjugatedForm: lyophilizedConcentration : 1 mg/mLPurification : Affinity chromatographyStorage buffer: PBS, pH 7.3,…
Product Name : Vinflunine ditartrateDescription:Vinflunine ditartrate is the first fluorinated microtubule inhibitor belonging to the Vinca alkaloids family. Vinflunine ditartrate has anti-angiogenic, vascular-disrupting and anti-metastatic activities. Vinflunine ditartrate can be…
Product Name : AMDHD1 Monoclonal Antibody (OTI4C1)Species Reactivity: HumanHost/Isotype : Mouse / IgG2aClass:MonoclonalType : AntibodyClone: OTI4C1Conjugate : UnconjugatedForm: LiquidConcentration : 1 mg/mLPurification : Affinity ChromatographyStorage buffer: PBS, pH 7.3, with…
Product Name : cIAP1 Ligand-Linker Conjugates 2 HydrochlorideDescription:cIAP1 Ligand-Linker Conjugates 2 Hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 2 Hydrochloride…
Product Name : ALOX5 Monoclonal Antibody (OTI1C1), TrueMAB™Species Reactivity: HumanHost/Isotype : Mouse / IgG1Class:MonoclonalType : AntibodyClone: OTI1C1Conjugate : UnconjugatedForm: lyophilizedConcentration : 1 mg/mLPurification : Affinity chromatographyStorage buffer: PBS, pH 7.3,…
Product Name : OkaninDescription:Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways.CAS: 484-76-4Molecular Weight:288.25Formula: C15H12O6Chemical Name: (2E)-3-(3,4-dihydroxyphenyl)-1-(2,3,4-trihydroxyphenyl)prop-2-en-1-oneSmiles : OC1=C(O)C(=CC=C1O)C(=O)/C=C/C1C=C(O)C(O)=CC=1InChiKey:…
Product Name : ALDH1L1 Polyclonal AntibodySpecies Reactivity: Human, Mouse, RatHost/Isotype : Rabbit / IgGClass:PolyclonalType : AntibodyClone: Conjugate : UnconjugatedForm: LiquidConcentration : 0.17 mg/mLPurification : Antigen affinity chromatographyStorage buffer: PBS, pH…
Product Name : JNJ0966Description:JNJ0966 is a highly selective compound that inhibits activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme. It has no effect on MMP-1, MMP-2, MMP-3,…
Product Name : ALDH1A1 Recombinant Rabbit Monoclonal Antibody (3X6B2)Species Reactivity: Human, Mouse, RatHost/Isotype : Rabbit / IgGClass:Recombinant MonoclonalType : AntibodyClone: 3X6B2Conjugate : UnconjugatedForm: LiquidConcentration : 0.2 mg/mLPurification : Affinity ChromatographyStorage…
Product Name : Thalidomide-O-amido-PEG2-C2-NH2 TFADescription:Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.CAS: 1957235-75-4Molecular Weight:576.48Formula:…
Product Name : AKAP12 Polyclonal AntibodySpecies Reactivity: Human, Mouse, RatHost/Isotype : Rabbit / IgGClass:PolyclonalType : AntibodyClone: Conjugate : UnconjugatedForm: LiquidConcentration : 0.28 mg/mLPurification : Antigen affinity chromatographyStorage buffer: PBS, pH…
Product Name : Bis-PEG2-acidDescription:Bis-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.CAS: 19364-66-0Molecular Weight:206.19Formula: C8H14O6Chemical Name: 3-propanoic acidSmiles : OC(=O)CCOCCOCCC(O)=OInChiKey: BOXWYBCUJGWEOJ-UHFFFAOYSA-NInChi : InChI=1S/C8H14O6/c9-7(10)1-3-13-5-6-14-4-2-8(11)12/h1-6H2,(H,9,10)(H,11,12)Purity: ≥98% (or…
Product Name : AHCY Monoclonal Antibody (M1)Species Reactivity: HumanHost/Isotype : Mouse / IgM, kappaClass:MonoclonalType : AntibodyClone: M1Conjugate : UnconjugatedForm: LiquidConcentration : See LabelPurification : Storage buffer: ascitesContains : no preservativeStorage…
Product Name : SenecionineDescription:Senecionine (Senecionan-11,16-dione, 12-hydroxy-) is a pyrrolizidine alkaloid isolated from Senecio vulgaris. Senecionine is toxic to animals and humans.CAS: 130-01-8Molecular Weight:335.39Formula: C18H25NO5Chemical Name: (1R,4Z,6R,7R,17R)-4-ethylidene-1,17-dihydrogenio-7-hydroxy-6,7-dimethyl-2,9-dioxa-14-azatricycloheptadec-11-ene-3,8-dioneSmiles : C1C/C(=C/C)/C(=O)O2CCN3CC=C(COC(=O)1(C)O)32InChiKey: HKODIGSRFALUTA-JTLQZVBZSA-NInChi :…
Product Name : 4-1BBL/CD137L/TNFSF9 Recombinant Rabbit Monoclonal Antibody (BLR148J)Species Reactivity: HumanHost/Isotype : Rabbit / IgGClass:Recombinant MonoclonalType : AntibodyClone: BLR148JConjugate : UnconjugatedForm: LiquidConcentration : 1 mg/mLPurification : purifiedStorage buffer: PBSContains :…
Product Name : 48740 RPDescription:48740 RP (RP-55778) is a platelet-activating factor (PAF) antagonist.CAS: 93363-11-2Molecular Weight:245.30Formula: C12H11N3OSChemical Name: 3-(pyridin-3-yl)-1H,3H-pyrrolothiazole-7-carboxamideSmiles : NC(=O)C1C=CN2C(SCC2=1)C1C=NC=CC=1InChiKey: ARFOASMERCHFBY-UHFFFAOYSA-NInChi : InChI=1S/C12H11N3OS/c13-11(16)9-3-5-15-10(9)7-17-12(15)8-2-1-4-14-6-8/h1-6,12H,7H2,(H2,13,16)Purity: ≥98% (or refer to the Certificate of…
Product Name : Morantel tartrateDescription:Morantel tartrate is a broad spectrum anthelmintic, effective and low toxicity.CAS: 26155-31-7Molecular Weight:370.42Formula: C16H22N2O6SChemical Name: (2R,3R)-2,3-dihydroxybutanedioic acid; 1-methyl-2--1,4,5,6-tetrahydropyrimidineSmiles : CC1C=CSC=1/C=C/C1=NCCCN1C.OC(=O)(O)(O)C(O)=OInChiKey: GGXQONWGCAQGNA-UUSVNAAPSA-NInChi : InChI=1S/C12H16N2S.C4H6O6/c1-10-6-9-15-11(10)4-5-12-13-7-3-8-14(12)2;5-1(3(7)8)2(6)4(9)10/h4-6,9H,3,7-8H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/b5-4+;/t;1-,2-/m.Fmoc-Ser(tBu)-OH Formula 1/s1Purity: ≥98%…
Product Name : Cyclosporin DDescription:Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A. Cyclosporin A is…
Product Name : Siomycin ADescription:Siomycin A is a thiopeptide antibiotic and is a Forkhead box M1(FOXM1) selective inhibitor without affecting other members of the Forkhead box family. Siomycin A has…
Product Name : JervineDescription:Jervine (11-Ketocyclopamine) is a Hedgehog signaling (IC50=500-700 nM) inhibitor that inhibits the sonic hedgehog (shh) pathway by interacting with smoothened.CAS: 469-59-0Molecular Weight:425.60Formula: C27H39NO3Chemical Name: (3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3-hydroxy-3',6',10,11b-tetramethyl-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3'H-spirofluorene-9,2'-furopyridin]-11-oneSmiles : C12CC(O)CC1=CC12C(=O)C21CC1(O3C(C)CN31C)C=2CInChiKey:…
Product Name : Z-Pro-Nle-Asp-CHOSequence: Z-Pro-Nle-Asp-HPurity: ≥95% (HPLC)Molecular Weight:478.5Solubility : Soluble in water (1mg/ml).Appearance: White to off-white solid.Use/Stability : As indicated on product label or CoA when stored as recommended. Store,…
Product Name : USP7-IN-1Description:USP7-IN-1 is a selective and reversible inhibitor of ubiquitin-specific protease 7 (USP7), with an IC50 of 77 μM, and can be used for the research of cancer.CAS:…
Product Name : U-75302Sequence: Purity: ≥98% (TLC)Molecular Weight:361.5Solubility : Soluble in DMSO (25 mg/ml) or ethanol (25 mg/ml).Appearance: Colorless oil.1242137-15-0 web Use/Stability : As indicated on product label or CoA…
Product Name : CorynoxineDescription:Corynoxine, a natural oxindole alkaloid, is a new autophagy enhancer.CAS: 6877-32-3Molecular Weight:384.47Formula: C22H28N2O4Chemical Name: methyl (2E)-2--7'-yl]-3-methoxyprop-2-enoateSmiles : CC1CN2CC3(2C1/C(=C\OC)/C(=O)OC)C1=CC=CC=C1NC3=OInChiKey: DAXYUDFNWXHGBE-NRAMRBJXSA-NInChi : InChI=1S/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15+,19+,22+/m1/s1Purity: ≥98% (or refer to the Certificate…
Product Name : SNAP-25 polyclonal antibodySequence: Purity: Molecular Weight:Solubility : Appearance: Use/Stability : Description: SNAP-25 (synaptosomal associated protein of 25kDa) is a soluble protein of 25kDa which plays a key…
Product Name : Nimustine hydrochlorideDescription:Nimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks and inhibits DNA synthesis, commonly…
Product Name : SB239063Sequence: Purity: ≥97% (HPLC)Molecular Weight:368.4Solubility : Soluble in DMSO, 100% ethanol or dichlormethane (may require slight warming).Appearance: White to off-white solid.Use/Stability : As indicated on product label or CoA…
Product Name : PyocyaninSequence: Purity: ≥98% (HPLC)Molecular Weight:210.2Solubility : Soluble in DMSO or dimethyl formamide.Appearance: Use/Stability : Stable for at least 1 year after receipt when stored at -80°C.Description: ROS…
Product Name : Vimentin monoclonal antibody (4A4)Sequence: Purity: Molecular Weight:Solubility : Appearance: Use/Stability : Description: Vimentin is one of four type II intermediate filament (IF) proteins; Desmin, Glial fibrillary acidic…
Product Name : PyroxamideDescription:Pyroxamide is a potent inhibitor of histone deacetylase 1 (HDAC1) with an ID50 of 100 nM. Pyroxamide can induce apoptosis and cell cycle arrest in leukemia.CAS: 382180-17-8Molecular…
Product Name : PKC kinase activity kitSequence: Purity: Molecular Weight:Solubility : Appearance: Use/Stability : Store all components at 4°C, except active kinase at -80°C.Description: Non-radioactive protein kinase activity assay provides…
Product Name : p62 ELISA kitSequence: Purity: Molecular Weight:Solubility : Appearance: Use/Stability : Store all components at +4ºC, except Standard at -80ºC.Description: Highly validated, quantitative p62 ELISA kit available for…
Product Name : (Z)-GW 5074Description:(Z)-GW 5074 is a compound which interacts with both mHTT (mutant huntingtin protein) and LC3, but not but not with the wild-type HTT protein. (Z)-GW 5074…
Product Name : 5-O-Desmethyl Omeprazole-d3Description:Product informationCAS: 1189679-99-9Molecular Weight:334.41Formula: C16H17N3O3SChemical Name: 2-{methanesulfinyl}-1H-1,3-benzodiazol-6-olSmiles : C()()OC1=C(C)C(CS(=O)C2NC3=CC(O)=CC=C3N=2)=NC=C1CInChiKey: TWXDTVZNDQKCOS-HPRDVNIFSA-NInChi : InChI=1S/C16H17N3O3S/c1-9-7-17-14(10(2)15(9)22-3)8-23(21)16-18-12-5-4-11(20)6-13(12)19-16/h4-7,20H,8H2,1-3H3,(H,18,19)/i3D3Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as…
Product Name : NonivamideSequence: Purity: ≥96% (HPLC)Molecular Weight:293.4Solubility : Soluble in DMSO or 100% ethanol; slightly soluble in water.{{60842-46-8} medchemexpress|{60842-46-8} Protocol|{60842-46-8} In stock|{60842-46-8} custom synthesis} Appearance: White to off-white solid.Use/Stability…
Product Name : NBQXSequence: Purity: ≥99% (HPLC)Molecular Weight:336.3Solubility : Soluble in DMSO. A 1mM aqueous solution may be prepared by taking up in >2.5 eq. of NaOH and backtitrating to…
Product Name : ITX5061Description:ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1).CAS: 1252679-52-9Molecular Weight:620.16Formula: C30H38ClN3O7SChemical Name: N-(5-tert-butyl-3-methanesulfonamido-2-methoxyphenyl)-2-{4-naphthalen-1-yl}-2-oxoacetamide hydrochlorideSmiles : Cl.COC1C(=CC(=CC=1NS(C)(=O)=O)C(C)(C)C)NC(=O)C(=O)C1=CC=C(OCCN2CCOCC2)C2=CC=CC=C21InChiKey: ICIJBYYMEBOTQP-UHFFFAOYSA-NInChi…
Product Name : MMP-9 inhibitor ISequence: Purity: ≥97% (HPLC)Molecular Weight:511.6Solubility : Soluble in DMSO.Appearance: White powder solid.Use/Stability : As indicated on product label or CoA when stored as recommended.Description: Cell-permeable,…
Product Name : LC3 monoclonal antibody (5H3)Sequence: Purity: Molecular Weight:Solubility : Appearance: Use/Stability : Stable at -20°C up to 1 year.Description: Autophagy is an alternative process of proteasomal degradation for…
Product Name : FKKDescription:FKK is an indazole derivative and also a novel bronchodilator.CAS: 78299-79-3Molecular Weight:347.25Formula: C17H19BrN2OChemical Name: 7-methyl-5-phenyl-1H,2H,3H-4λ⁵-pyrazoloindazol-4-ylium hydrate bromideSmiles : O..CC1C=C2C(C3C=CC=CC=3)=3CCCN3C2=CC=1InChiKey: QMEOEOBNKLHQJB-UHFFFAOYSA-MInChi : InChI=1S/C17H17N2.BrH.H2O/c1-13-8-9-16-15(12-13)17(14-6-3-2-4-7-14)19-11-5-10-18(16)19;;/h2-4,6-9,12H,5,10-11H2,1H3;1H;1H2/q+1;;/p-1Purity: ≥98% (or refer to the…
Product Name : Kanamycin . sulfateSequence: Purity: Molecular Weight:484.5 . 98.1Solubility : Soluble in water.Appearance: White to off-white crystalline powder.Use/Stability : As indicated on product label or CoA when stored…
Product Name : IHC Wash Buffer (10X)Sequence: Purity: Molecular Weight:Solubility : Appearance: Use/Stability : Description: The IHC wash buffer is a for washing and removing excess reagents during immunostaining.Optimal immunostaining…
Product Name : GBR 12783Description:GBR 12783 is a specific, potent and selective dopamine uptake inhibitor that inhibits the dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8…
Product Name : 2, 4, 5, 6-TetraaminopyrimidineDescription:2,4,5,6-Tetraaminopyrimidine is a coloring agent extracted from patent US20170258692A1, compound A.CAS: 1004-74-6Molecular Weight:140.15Formula: C4H8N6Chemical Name: pyrimidine-2,4,5,6-tetramineSmiles : NC1N=C(N)N=C(N)C=1NInChiKey: PZRKPUQWIFJRKZ-UHFFFAOYSA-NInChi : InChI=1S/C4H8N6/c5-1-2(6)9-4(8)10-3(1)7/h5H2,(H6,6,7,8,9,10)Purity: ≥98% (or refer…
Product Name : Pseudoginsenoside RT5Description:Pseudoginsenoside RT5 is isolated from Panax quinquefolium.CAS: 98474-78-3Molecular Weight:654.87Formula: C36H62O10Chemical Name: (2R,3R,4S,5S,6R)-2-{-3a,3b,6,6,9a-pentamethyl-hexadecahydro-1H-cyclopentaphenanthren-5-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triolSmiles : CC(C)(O)1CC(C)(O1)1CC2(C)1(O)C13(C)CC(O)C(C)(C)3(C21C)O1O(CO)(O)(O)1OInChiKey: PSOUXXNNRFNUAY-JLXGCTMESA-NInChi : InChI=1S/C36H62O10/c1-31(2)23(39)10-12-33(5)22-15-19(38)25-18(36(8)14-11-24(46-36)32(3,4)43)9-13-34(25,6)35(22,7)16-20(29(31)33)44-30-28(42)27(41)26(40)21(17-37)45-30/h18-30,37-43H,9-17H2,1-8H3/t18-,19+,20-,21+,22+,23-,24+,25-,26+,27-,28+,29-,30+,33+,34+,35+,36-/m0/s1Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition:…
Product Name : Thyrotropin-Releasing Hormone (TRH), Free AcidDescription:Thyrotropin-Releasing Hormone (TRH), Free Acid (TRH-OH) is a physiological metabolite of Thyrotropin-Releasing Hormone.CAS: 24769-58-2Molecular Weight:363.37Formula: C16H21N5O5Chemical Name: (2S)-1-formamido}propanoyl]pyrrolidine-2-carboxylic acidSmiles : OC(=O)1CCCN1C(=O)(CC1=CN=CN1)NC(=O)1CCC(=O)N1InChiKey: ITYONPBTNRIEBA-SRVKXCTJSA-NInChi :…
Product Name : Apelin-36(human)Description:Apelin-36(human) is an endogenous orphan G protein-coupled receptor APJ agonist, with an EC50 of 20 nM. Apelin-36(human) shows high affinity to human APJ receptors expressed in HEK…
Product Name : L-Homoserine lactone hydrochlorideSynonym: (S)-&alpha,-Amino-&gamma,-butyrolactone hydrochloride, HSI, L-HSL, (S)-Homoserine lactone hydrochlorideCAS : 2185-03-7Molecular formula:C4H7NO2 · HClMolecular Weight : 137.56Purity: ≥98% (Titration)Specifications: Purity ≥98% (Titration)|Appearance White to off-white powder|Identity…
Product Name : N-Methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy3Description:N-Methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.CAS: 2107273-64-1Molecular Weight:860.48Formula: C44H66ClN5O10Chemical Name: 2--1,3,3-trimethyl-2,3-dihydro-1H-indol-2-ylidene]prop-1-en-1-yl]-1,3,3-trimethyl-5-(2,5,8,11-tetraoxatridecan-13-yloxy)-3H-indol-1-ium chlorideSmiles : .COCCOCCOCCOCCOC1=CC2=C(C=C1)(C)=C(/C=C/C=C1/N(C)C3=CC=C(C=C3C/1(C)C)OCCOCCOCCOCCOCCN==)C2(C)CInChiKey: FHRNKBLFTPHSBL-UHFFFAOYSA-MInChi : InChI=1S/C44H66N5O10.ClH/c1-43(2)37-33-35(58-31-29-56-27-25-54-22-21-52-18-17-50-7)11-13-39(37)48(5)41(43)9-8-10-42-44(3,4)38-34-36(12-14-40(38)49(42)6)59-32-30-57-28-26-55-24-23-53-20-19-51-16-15-46-47-45;/h8-14,33-34H,15-32H2,1-7H3;1H/q+1;/p-1Purity: ≥98%…
Product Name : FAMCSynonym: 3-(4,6-Difluorotriazinyl)amino-7-methoxycoumarinCAS : 127192-67-0Molecular formula:C13H8F2N4O3Molecular Weight : 203.28Purity: ≥95% (NMR)Specifications: Purity ≥95% (NMR)|Appearance Solid|Identity 1H-NMR|PropertiesSolvents DMSO or chloroform|Fluorescence λex 340 nm, λem 421 nm in 0.{{1019206-88-2} MedChemExpress|{1019206-88-2}…
Product Name : DAF-2 DA solution (5 mM in DMSO), 1 mg in 0.45 ml DMSOSynonym: 4,5-Diaminofluorescein diacetate , 5,6-Diaminofluorescein diacetateCAS : 205391-02-2Molecular formula:C24H18N2O7Molecular Weight : 446.{{2563855-03-6} medchemexpress|{2563855-03-6} Purity &…
Product Name : 3-(2-Pyridyldithio)propanoic AcidDescription:3-(2-Pyridyldithio)propanoic Acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.CAS: 68617-64-1Molecular Weight:215.29Formula: C8H9NO2S2Chemical Name: 3-(pyridin-2-yldisulfanyl)propanoic acidSmiles : OC(=O)CCSSC1=CC=CC=N1InChiKey: DJBRKGZFUXKLKO-UHFFFAOYSA-NInChi…
Product Name : Tyramine hydrochlorideDescription:Tyramine hydrochloride is an amino acid that helps regulate blood pressure. Tyramine hydrochloride occurs naturally in the body, and it's found in certain foods.CAS: 60-19-5Molecular Weight:173.64Formula:…
Product Name : ASPTSynonym: trans-4--1-methylpyridinium tetraphenylborateCAS : 159721-38-7Molecular formula:C42H43BN2OMolecular Weight : 602.61Purity: ≥95% (HPLC)Specifications: Purity ≥95% (HPLC)|Appearance Orange to red powder|Identity 1H-NMR|PropertiesSolvents acetonitrile, DMSO|Fluorescence λex 484 nm, λem 601 nm…
Product Name : 5-Geranyloxy-7-methoxycoumarinSynonym: 5-G-7-MOC , 7-Methoxy-5-geranoxycoumarinCAS : 7380-39-4Molecular formula:C20H24O4Molecular Weight : 328.41Purity: ≥98% (HPLC)Specifications: Purity ≥98% (HPLC)|Appearance White to off-white powder|Identity 1H-NMR|PropertiesSolvents Soluble in DMSO or chloroform.{{941678-49-5} MedChemExpress|{941678-49-5} Purity…
Product Name : ButopyronoxylDescription:Butopyronoxyl is an insect repellent that can be mainly used to repel mosquitoes.CAS: 532-34-3Molecular Weight:226.27Formula: C12H18O4Chemical Name: butyl 2,2-dimethyl-4-oxo-3,4-dihydro-2H-pyran-6-carboxylateSmiles : CCCCOC(=O)C1=CC(=O)CC(C)(C)O1InChiKey: OKIJSNGRQAOIGZ-UHFFFAOYSA-NInChi : InChI=1S/C12H18O4/c1-4-5-6-15-11(14)10-7-9(13)8-12(2,3)16-10/h7H,4-6,8H2,1-3H3Purity: ≥98% (or refer…
Product Name : A-9758Description:A-9758 is a RORγ ligand and a potent, selective RORγt inverse agonist (IC50=5 nM), and exhibits robust potency against IL-17A release. A-9758 is effective in suppressing both…
Product Name : D-DesthiobiotinDescription:D-Desthiobiotin is a biotin derivative used in affinity chromatography and protein chromatography, also can be used for protein and cell labeling, detection and isolation.CAS: 533-48-2Molecular Weight:214.26Formula: C10H18N2O3Chemical…
Product Name : MBP Nanoselector Magnetic beadsApplications: IP,CHIP,MS,PurificationReactivity : MBPConjugate:Magnetic beadsAdvantages : · Consistent and reproducible results;· No heavy & light antibody chains Extraordinarybinding,even under harsh conditions;· High affinity and…
Product Name : Tetrazine-biotinDescription:Tetrazine-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).CAS: 1714123-51-9Molecular Weight:413.50Formula: C19H23N7O2SChemical Name: 5-imidazol-4-yl]-N-{methyl}pentanamideSmiles : O=C(CCCC1SC2NC(=O)N21)NCC1=CC=C(C=C1)C1N=NC=NN=1InChiKey: GBJXXSUDJUYIIH-ZOBUZTSGSA-NInChi : InChI=1S/C19H23N7O2S/c27-16(4-2-1-3-15-17-14(10-29-15)23-19(28)24-17)20-9-12-5-7-13(8-6-12)18-25-21-11-22-26-18/h5-8,11,14-15,17H,1-4,9-10H2,(H,20,27)(H2,23,24,28)/t14-,15-,17-/m0/s1Purity: ≥98% (or refer…
Product Name : Chroman 1 dihydrochlorideDescription:Chroman 1 dihydrochloride is a highly potent and selective ROCK inhibitor. Chroman 1 dihydrochloride is more potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM).…
Product Name : JTT 551CAS No.: 776309-04-7Purity : > 99%Shipping:Shipped on dry ice.Storage : Protect from light.Powder: -80 °C, 2 years; -20 °C, 1 year.In solvent: -80 °C, 6 months;…
Product Name : Anti-Mouse IgG1(Fcγ Fragment specific), AlpSdAbs® VHH(iFluor488)Applications: WB,ICC/IF,ELISA,Flow CytReactivity : Mouse IgG1(Fcγ Fragment specific)Conjugate:iFluor488Advantages : High lot-to-lot consistencyIncreased sensitivity and higher affinityAnimal-free productionDescription: | Description: Anti-Mouse IgG1(Fcγ Fragment…
Product Name : N-Boc-piperazineDescription:N-Boc-piperazine is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183).CAS: 57260-71-6Molecular Weight:186.25Formula: C9H18N2O2Chemical Name: tert-butyl piperazine-1-carboxylateSmiles : CC(C)(C)OC(=O)N1CCNCC1InChiKey: CWXPZXBSDSIRCS-UHFFFAOYSA-NInChi…
Product Name : Anti-PD1/CD279(Pidilizumab Biosimilar) AntibodyApplications: ELISA,Flow CytReactivity : Human PDCD1/CD279/PD1Conjugate:UnconjugatedAdvantages : High lot-to-lot consistencyIncreased sensitivity and higher affinityAnimal-free productionDescription: | Description: Anti-PD1/CD279(Pidilizumab Biosimilar) Antibody is a biosimilar antibody directed…
Product Name : Anti-OX40L/CD134(Tavolimab Biosimilar) AntibodyApplications: ELISA,Flow CytReactivity : Human TNFSF4/CD134/CD252/OX40LConjugate:UnconjugatedAdvantages : High lot-to-lot consistencyIncreased sensitivity and higher affinityAnimal-free productionDescription: | Description: Anti-OX40L/CD134(Tavolimab Biosimilar) Antibody is a biosimilar antibody directed…
Product Name : Anti-LRRC32(Livmoniplimab Biosimilar) AntibodyApplications: ELISA,Flow CytReactivity : Human LRRC32Conjugate:UnconjugatedAdvantages : High lot-to-lot consistencyIncreased sensitivity and higher affinityAnimal-free productionDescription: | Description: Anti-LRRC32(Livmoniplimab Biosimilar) Antibody is a biosimilar antibody directed…
Product Name : Diltiazem-d6Description:Product informationCAS: 1242184-41-3Molecular Weight:420.55Formula: C22H26N2O4SChemical Name: (2S,3S)-5-{2-ethyl}-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetateSmiles : C()()N(CCN1C(=O)(OC(C)=O)(SC2=CC=CC=C12)C1C=CC(=CC=1)OC)C()()InChiKey: HSUGRBWQSSZJOP-NFBMDBORSA-NInChi : InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1/i2D3,3D3Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as…
Product Name : Anti-IL12B/CLMFp40(Briakinumab Biosimilar) AntibodyApplications: ELISA,Flow CytReactivity : Human IL12B/CLMFp40Conjugate:UnconjugatedAdvantages : High lot-to-lot consistencyIncreased sensitivity and higher affinityAnimal-free productionDescription: | Description: Anti-IL12B/CLMFp40(Briakinumab Biosimilar) Antibody is a biosimilar antibody directed…
Product Name : Anti-V5 tag, AlpSdAbs® VHH(Biotin)Applications: WB,ELISA,IP,Purification,BLI,SPRReactivity : V5 tagConjugate:BiotinAdvantages : High lot-to-lot consistencyIncreased sensitivity and higher affinityAnimal-free productionDescription: | Description: Anti-V5 tag, AlpSdAbs® VHH(Biotin) is designed for detecting…
Product Name : (Rac)-5-Hydroxymethyl desisopropyl Tolterodine-d6Description:Product informationCAS: 1189419-89-3Molecular Weight:305.44Formula: C19H25NO2Chemical Name: 4-(hydroxymethyl)-2-(1-phenyl-3-{amino}propyl)phenolSmiles : C()()C(NCCC(C1=CC(CO)=CC=C1O)C1C=CC=CC=1)C()()InChiKey: CCZYBOXFQXWQIF-WFGJKAKNSA-NInChi : InChI=1S/C19H25NO2/c1-14(2)20-11-10-17(16-6-4-3-5-7-16)18-12-15(13-21)8-9-19(18)22/h3-9,12,14,17,20-22H,10-11,13H2,1-2H3/i1D3,2D3Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature…
Product Name : T-91825Description:T-91825 (PPI-0903M), an N-phosphono-type cephalosporin, is the active form of TAK-599. T-91825 is active against both gram-positive and gram-negative bacteria.CAS: 189345-04-8Molecular Weight:604.70Formula: C22H20N8O5S4Chemical Name: 4-(2-{-2-carboxylato-8-oxo-5-thia-1-azabicyclooct-2-en-3-yl]sulfanyl}-1,3-thiazol-4-yl)-1-methylpyridin-1-iumSmiles : CCO/N=C(/C1N=C(N)SN=1)\C(=O)N12SCC(SC3=NC(=CS3)C3C=C(C)=CC=3)=C(C()=O)N2C1=OInChiKey:…
Product Name : Anti-Human CD206/MRC1, AlpSdAbs® VHHApplications: ELISAReactivity : Human CD206/MRC1Conjugate:UnconjugatedAdvantages : High lot-to-lot consistencyAnimal-free productionDescription: | Description: Anti-Human CD206/MRC1, AlpSdAbs® VHH is designed for detecting Human CD206/MRC1, and Anti-Human…
Product Name : Anti-Rat IgG(Fcγ Fragment specific), Goat antibody(HRP)Applications: ELISA,WBReactivity : Rat IgG(Fcγ Fragment specific)Conjugate:HRPAdvantages : High lot-to-lot consistencyIncreased sensitivity and higher affinityAnimal-free productionDescription: | Description: Anti-Rat IgG(Fcγ Fragment specific),…
Product Name : Fipexide hydrochlorideDescription:Fipexide hydrochloride, a parachloro-phenossiacetic acid derivative, is a nootropic drug. Fipexide hydrochloride reduces striatal adenylate cyclase activity. Fipexide hydrochloride has positive effect on cognitive performance by…
Product Name : PaeoniflorgeninDescription:Paeoniflorgenin is a deglucosylated metabolite of Paeoniflorin.CAS: 697300-41-7Molecular Weight:318.32Formula: C17H18O6Chemical Name: decan-2-yl]methyl benzoateSmiles : C12C3(O)OC(O1)1(COC(=O)C4C=CC=CC=4)3C12OInChiKey: GWQHMWOOQLVRLG-BZEIYFPWSA-NInChi : InChI=1S/C17H18O6/c1-14-8-16(19)11-7-17(14,20)15(11,13(22-14)23-16)9-21-12(18)10-5-3-2-4-6-10/h2-6,11,13,19-20H,7-9H2,1H3/t11-,13?,14+,15+,16-,17-/m1/s1Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition:…
Product Name : Anti-Rabbit IgG kappa, Goat antibody(Biotin)Applications: WB,ELISA,IPReactivity : Rabbit IgG kappaConjugate:BiotinAdvantages : High lot-to-lot consistencyIncreased sensitivity and higher affinityAnimal-free productionDescription: | Description: Anti-Rabbit IgG kappa, Goat antibody(Biotin) is…
Product Name : Anti-IL2RA, Human antibodyApplications: ELISA,Flow CytReactivity : HumanConjugate:UnconjugatedAdvantages : High lot-to-lot consistencyIncreased sensitivity and higher affinityAnimal-free productionDescription: | Description: Anti-IL2RA, Human antibody is designed for detecting human IL2RA…
Product Name : Ganoderic acid GDescription:Ganoderic acid G is a triterpene isolated from the surface part of gills of Ganoderma lucidum.CAS: 98665-22-6Molecular Weight:532.67Formula: C30H44O8Chemical Name: 2-methyl-4-oxo-6-{4,7,11-trihydroxy-3a,6,6,9a,11a-pentamethyl-3,10-dioxo-1H,2H,3H,3aH,4H,5H,5aH,6H,7H,8H,9H,9aH,10H,11H,11aH-cyclopentaphenanthren-1-yl}heptanoic acidSmiles : CC1(C)C2CC(O)C3=C(C(=O)C(O)C4(C)C(CC(=O)C43C)C(C)CC(=O)CC(C)C(O)=O)C2(C)CCC1OInChiKey: BPJPBLZKOVIJQD-UHFFFAOYSA-NInChi…
Product Name : AcetylcysteineCAS No.: 616-91-1Purity : > 99%Shipping:Shipped on dry ice.Storage : Powder: -20 °C, 3 years; 4 °C, 2 yearsIn solvent: -80 °C, 6 months; -20 °C, 1…
Product Name : Fluorometholone AcetateCAS No.: 3801-06-7Purity : > 99%Shipping:Shipped on dry ice.Storage : Powder: -20 °C, 3 years; 4 °C, 2 yearsIn solvent: -80 °C, 6 months; -20 °C,…
Product Name : Tenalisib R EnantiomerDescription:Tenalisib R Enantiomer (RP6530 R Enantiomer) is an R enantiomer of Tenalisib. Tenalisib is a potent and selective PI3Kδ and PI3Kγ inhibitor with IC50 values…
Product Name : Cinnamyl-3,4-dihydroxy-α-cyanocinnamateCAS No.: 132465-11-3Purity : > 99%Shipping:Shipped on dry ice.Storage : Protect from light.Powder: -80 °C, 2 years; -20 °C, 1 year.In solvent: -80 °C, 6 months; -20…
Product Name : CarnostatineCAS No.: Purity : > 98%Shipping:Shipped on dry ice.Storage : Protect from light.Powder: -80 °C, 2 years; -20 °C, 1 year.In solvent: -80 °C, 6 months; -20…
Product Name : Dox-Ph-PEG1-ClDescription:Dox-Ph-PEG1-Cl (PROTAC Linker 34) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.CAS: 773095-86-6Molecular Weight:228.67Formula: C11H13ClO3Chemical Name: 2--1,3-dioxolaneSmiles : ClCCOC1C=CC(=CC=1)C1OCCO1InChiKey: UWZOSXKGJXGPBP-UHFFFAOYSA-NInChi : InChI=1S/C11H13ClO3/c12-5-6-13-10-3-1-9(2-4-10)11-14-7-8-15-11/h1-4,11H,5-8H2Purity:…
Product Name : AR-A014418CAS No.: 487021-52-3Purity : > 99%Shipping:Shipped on dry ice.Storage : Store at +4 °C. The product can be stored for up to 12 months.SMILES: O=C(Nc1ncc(s1)()=O)NCc2ccc(OC)cc2Product Description :…
Product Name : Skepinone-LCAS No.: 1221485-83-1Purity : > 99%Shipping:Shipped on dry ice.Storage : Powder: -20 °C, 3 years; 4 °C, 2 yearsIn solvent: -80 °C, 6 months; -20 °C, 1…
Product Name : PQR626Description:PQR626, a rapamycin derivative, is a potent, selective, orally active, and brain-penetrant mTOR inhibitor, with an IC50 and Ki of 5 nM and 3.6 nM, respectively. PQR626…
Product Name : 3'-Azido-3'-deoxy-5-fluorocytidineDescription:3'-Azido-3'-deoxy-5-fluorocytidine (Compound 12) is a cytidine derivative.CAS: 2095417-18-6Molecular Weight:286.22Formula: C9H11FN6O4Chemical Name: 4-amino-1--5-fluoro-1, 2-dihydropyrimidin-2-oneSmiles : ==N1(CO)O(1O)N1C=C(F)C(N)=NC1=OInChiKey: MOEHIWUXKDQZBL-UAKXSSHOSA-NInChi : InChI=1S/C9H11FN6O4/c10-3-1-16(9(19)13-7(3)11)8-6(18)5(14-15-12)4(2-17)20-8/h1,4-6,8,17-18H,2H2,(H2,11,13,19)/t4-,5-,6-,8-/m1/s1Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition:…
Product Name : MAP4343Description:MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and…
Product Name : Tetromycin ADescription:Tetromycin A, as an unusual tetronic acid, is a tetronic acid-based antibiotic. It is structurally related to saccharocarcin, chlorothricin, tetrocarcin, kijanimicin and versipelostatin and has been…
Product Name : Deuterated Atazanivir-D3-3Description:Atazanivir-D3-3 is a azapeptide derivative and inhibits HIV protease.CAS: 1092540-52-7Molecular Weight:722.97Formula: C38H52N6O7Chemical Name: methyl N--3,3-di(²H₃)methyl(4,4,4-²H₃)butanamido]-4-phenylbutyl]-N'-{methyl}hydrazinecarbonyl}-2,2-di(²H₃)methyl(3,3,3-²H₃)propyl]carbamateSmiles : C()()C((NC(=O)OC)C(=O)NN(CC1C=CC(=CC=1)C1C=CC=CN=1)C(O)(CC1C=CC=CC=1)NC(=O)(NC(=O)OC)C(C()())(C()())C()())(C()())C()()InChiKey: AXRYRYVKAWYZBR-AAPVVJSESA-NInChi : InChI=1S/C38H52N6O7/c1-37(2,3)31(41-35(48)50-7)33(46)40-29(22-25-14-10-9-11-15-25)30(45)24-44(43-34(47)32(38(4,5)6)42-36(49)51-8)23-26-17-19-27(20-18-26)28-16-12-13-21-39-28/h9-21,29-32,45H,22-24H2,1-8H3,(H,40,46)(H,41,48)(H,42,49)(H,43,47)/t29-,30-,31+,32+/m0/s1/i1D3,2D3,3D3,4D3,5D3,6D3Purity: ≥98% (or refer to the Certificate…
Product Name : α-Methyl-5-hydroxytryptamine maleateDescription:Product informationCAS: 97469-12-0Molecular Weight:306.31Formula: C15H18N2O5Chemical Name: (2Z)-but-2-enedioic acid; 3--1H-indol-5-olSmiles : C(N)CC1=CNC2=CC=C(O)C=C21.OC(=O)/C=C\C(O)=OInChiKey: YQNHFSXRABPJLP-DGHJNVJVSA-NInChi : InChI=1S/C11H14N2O.C4H4O4/c1-7(12)4-8-6-13-11-3-2-9(14)5-10(8)11;5-3(6)1-2-4(7)8/h2-3,5-7,13-14H,4,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t7-;/m1./s1Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient…
Product Name : GSK-3β Inhibitor IIDescription:IC50: 390 nM for GSK-3β GSK-3β Inhibitor II is a GSK-3β inhibitor. Glycogen Synthase Kinase-3 (GSK-3), a protein-serine kinase, is implicated in the hormonal control…
Product Name : 3, 3', 5'-Triiodo-L-thyronineDescription:3,3',5'-triiodo-L-thyronine (reverse T3 or rT3) and 3,5,3'-triiodo-L-thyronine (T3) are the metabolism of thyroxine (T4) . 3,3',5'-Triiodo-L-thyronine is thyroid hormone receptors TRα and TRβ antagonist .…
Product Name : WAY 629 hydrochlorideDescription:Product informationCAS: 57756-44-2Molecular Weight:262.78Formula: C15H19ClN2Chemical Name: 7,10-diazatetracycloheptadeca-1,3,5(17),11(16)-tetraene hydrochlorideSmiles : Cl.C1NCCN2C3C(=CC=CC=31)C1CCCCC2=1InChiKey: PZXUJERSOFOWES-UHFFFAOYSA-NInChi : InChI=1S/C15H18N2.ClH/c1-2-7-14-12(5-1)13-6-3-4-11-10-16-8-9-17(14)15(11)13;/h3-4,6,16H,1-2,5,7-10H2;1HPurity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient…
Product Name : Rac-NedisertibDescription:Rac-Nedisertib (Rac-M3814) is a racemate of Nedisertib, a potent DNA-PK inhibitor, with an IC50 of
Product Name : 2, 4, 6-Tribromophenyl caproateDescription:2,4,6-Tribromophenyl caproate (2,4,6-tribromophenyl caproic acid ester) is an anti-fungal agent.CAS: 16732-09-5Molecular Weight:428.94Formula: C12H13Br3O2Chemical Name: 2,4,6-tribromophenyl hexanoateSmiles : CCCCCC(=O)OC1C(Br)=CC(Br)=CC=1BrInChiKey: WKADNUIXFNFRSW-UHFFFAOYSA-NInChi : InChI=1S/C12H13Br3O2/c1-2-3-4-5-11(16)17-12-9(14)6-8(13)7-10(12)15/h6-7H,2-5H2,1H3Purity: ≥98% (or refer…
Product Name : CandoxatrilDescription:Candoxatril is a neutral endopeptidase (NEP) inhibitor.CAS: 123122-55-4Molecular Weight:515.64Formula: C29H41NO7Chemical Name: (1s,4s)-4-{1--3-oxopropyl]cyclopentaneamido}cyclohexane-1-carboxylic acidSmiles : COCCOC(CC1(CCCC1)C(=O)N1CC(CC1)C(O)=O)C(=O)OC1C=C2CCCC2=CC=1InChiKey: ZTWZVMIYIIVABD-OEMFJLHTSA-NInChi : InChI=1S/C29H41NO7/c1-35-15-16-36-19-23(27(33)37-25-12-9-20-5-4-6-22(20)17-25)18-29(13-2-3-14-29)28(34)30-24-10-7-21(8-11-24)26(31)32/h9,12,17,21,23-24H,2-8,10-11,13-16,18-19H2,1H3,(H,30,34)(H,31,32)/t21-,23-,24+/m0/s1Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition:…
Product Name : 3-MethylcrotonylglycineDescription:3-Methylcrotonylglycine is an acyl glycine, a normal amino acid metabolite found in urine.CAS: 33008-07-0Molecular Weight:157.17Formula: C7H11NO3Chemical Name: 2-(3-methylbut-2-enamido)acetic acidSmiles : CC(C)=CC(=O)NCC(O)=OInChiKey: PFWQSHXPNKRLIV-UHFFFAOYSA-NInChi : InChI=1S/C7H11NO3/c1-5(2)3-6(9)8-4-7(10)11/h3H,4H2,1-2H3,(H,8,9)(H,10,11)Purity: ≥98% (or refer…
Product Name : Resorufin pentyl etherDescription:Resorufin pentyl ether (Pentoxyresorufin) is a Resazurin (HY-111391) analogue. Resorufin pentyl ether can function as a substrate probe to characterize and differentiate between a variety…
Product Name : RetosibanDescription:Retosiban (GSK221149A) is a potent and selective oxytocin antagonist with a Ki of 0.65 nM.CAS: 820957-38-8Molecular Weight:494.58Formula: C27H34N4O5Chemical Name: (3R,6R)-6--3-(2,3-dihydro-1H-inden-2-yl)-1-piperazine-2,5-dioneSmiles : CC1=NC(=CO1)(C(=O)N1CCOCC1)N1((C)CC)C(=O)N(C2CC3C=CC=CC=3C2)C1=OInChiKey: PLVGDGRBPMVYPB-FDUHJNRSSA-NInChi : InChI=1S/C27H34N4O5/c1-4-16(2)23-25(32)29-22(20-13-18-7-5-6-8-19(18)14-20)26(33)31(23)24(21-15-36-17(3)28-21)27(34)30-9-11-35-12-10-30/h5-8,15-16,20,22-24H,4,9-14H2,1-3H3,(H,29,32)/t16-,22+,23+,24+/m0/s1Purity: ≥98% (or…
Product Name : MCL-1/BCL-2-IN-2Description:MCL-1/BCL-2-IN-2 (Compound 6) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor.CAS: 2163793-44-8Molecular Weight:427.31Formula: C20H15BrN2O2SChemical Name: 3-(2-aminoethyl)-8--3-azatricyclotrideca-1(13),5,7,9,11-pentaene-2,4-dioneSmiles : NCCN1C(=O)C2C=CC=C3C=2C(=CC=C3SC2C=CC(Br)=CC=2)C1=OInChiKey: LPOALFWTLPKKNW-UHFFFAOYSA-NInChi : InChI=1S/C20H15BrN2O2S/c21-12-4-6-13(7-5-12)26-17-9-8-16-18-14(17)2-1-3-15(18)19(24)23(11-10-22)20(16)25/h1-9H,10-11,22H2Purity: ≥98% (or refer to…
Product Name : 1-Methyl-L-histidineDescription:1-Methyl-L-histidine is an objective indicator of meat ingestion and exogenous 3-methylhistidine (3MH) intake.CAS: 332-80-9Molecular Weight:169.18Formula: C7H11N3O2Chemical Name: 2-amino-3-(1-methyl-1H-imidazol-4-yl)propanoic acidSmiles : CN1C=C(CC(N)C(O)=O)N=C1InChiKey: BRMWTNUJHUMWMS-UHFFFAOYSA-NInChi : InChI=1S/C7H11N3O2/c1-10-3-5(9-4-10)2-6(8)7(11)12/h3-4,6H,2,8H2,1H3,(H,11,12)Purity: ≥98% (or refer…
Product Name : SalsolidineDescription:Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor.CAS: 5784-74-7Molecular Weight:207.27Formula: C12H17NO2Chemical Name: 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinolineSmiles : COC1=CC2C(C)NCCC=2C=C1OCInChiKey: HMYJLVDKPJHJCF-UHFFFAOYSA-NInChi : InChI=1S/C12H17NO2/c1-8-10-7-12(15-3)11(14-2)6-9(10)4-5-13-8/h6-8,13H,4-5H2,1-3H3Purity: ≥98% (or refer to…
Product Name : Ambroxol hydrochlorideDescription:Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the prodrug Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity.…
Product Name : ExherinDescription:Exherin, also known as ADH-1, is a small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks N-cadherin,…
Product Name : ZM323881 HydrochlorideDescription:ZM323881 is a potent and selective inhibitor of VEGF-R2 tyrosine kinase in vitro (IC(50) 50 microM). ZM323881 inhibits VEGF-A-induced endothelial cell proliferation (IC(50) = 8 nM)…
Product Name : Tulathromycin ADescription:Tulathromycin A, also known as Tulathromycin and CP-472295, is a macrolide antibiotic used to treat bovine respiratory disease (BRD) in cattle and swine respiratory disease in…
Product Name : AltretamineDescription:Altretamine is a synthetic cytotoxic s-triazine derivative similar in structure to alkylating agent triethylenemelamin with antineoplastic activity. Although the precise mechanism by which altretamine exerts its cytotoxic…
Product Name : RamiprilDescription:Ramipril is an inhibitor of the angiotensin- converting enzyme that is reported to quickly hydrolyze into the active metabolite Ramiprilat. Angiotensin-converting enzyme (ACE) removes the C-terminal dipeptide…
Product Name : Tolfenamic AcidDescription:Tolfenamic acid, also known as Clotam, is a non-steroidal anti-inflammatory agent. Tolfenamic acid interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting…
Product Name : N3-C2-NHS esterDescription:N3-C2-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).CAS: 850180-76-6Molecular Weight:212.16Formula: C7H8N4O4Chemical Name: 2,5-dioxopyrrolidin-1-yl 3-azidopropanoateSmiles : ==NCCC(=O)ON1C(=O)CCC1=OInChiKey: WATICTZQAVLEKN-UHFFFAOYSA-NInChi : InChI=1S/C7H8N4O4/c8-10-9-4-3-7(14)15-11-5(12)1-2-6(11)13/h1-4H2Purity:…
Product Name : DPDPE TFADescription:DPDPE TFA, an opioid peptide, is a selective δ-opioid receptor (DOR) agonist with anticonvulsant effects.CAS: 172888-59-4Molecular Weight:759.81Formula: C32H40F3N5O9S2Chemical Name: (4S,13S)-13--7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid; trifluoroacetic acidSmiles : CC1(C)SSC(C)(C)(NC(=O)C(CC2C=CC=CC=2)NC(=O)CNC(=O)1NC(=O)(N)CC1C=CC(O)=CC=1)C(O)=O.OC(=O)C(F)(F)FInChiKey: LUVILUYVBUMMRG-ISHGPQPLSA-NInChi…
Product Name : LasiocarpineDescription:Lasiocarpine, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo. Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine…
Product Name : Phenytoin sodiumDescription:Phenytoin sodium (5,5-Diphenylhydantoin sodium salt) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice.CAS:…
Product Name : DYRK1-IN-1Description:DYRK1-IN-1 is a highly selective and ligand-efficient DYRK1A inhibitor. DYRK1-IN-1 inhibits DYRK1A phosphorylation activity with an IC50 value of 220 nM. DYRK1-IN-1 can be used for the…
Product Name : NVS-PI3-4Description:NVS-PI3-4 is a specific PI3Kγ inhibitor. NVS-PI3-4 can be used for the research of allergies, inflammatory and cancer diseases.CAS: 941580-60-5Molecular Weight:402.51Formula: C20H26N4O3SChemical Name: 3-({carbamoyl}amino)-N-tert-butylpropanamideSmiles : CC(=O)C1=CC=C(C=C1)C1SC(NC(=O)NCCC(=O)NC(C)(C)C)=NC=1CInChiKey: IUPXLLWDLOWEBR-UHFFFAOYSA-NInChi…
Product Name : (3S, 5S)-AtorvastatinDescription:(3S,5S)-Atorvastatin is a inactive enantiomer of Atorvastatin. (3S,5S)-Atorvastatin can activate pregnane X receptor (PXR). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to…
Product Name : 7-TFA-ap-7-Deaza-ddADescription:7-TFA-ap-7-Deaza-ddA (compound 19c, US20060281100A1), a nucleotide derivative, can be used in the synthesis of thiotriphosphate nucleotide dye terminators which can be used in DNA sequencing reactions.CAS: 114748-71-9Molecular…
Product Name : Nav1.7-IN-1Description:PF-05089771 is a Selective Nav1.7 Inhibitor (IC50 = 11 nM) that interacts with the voltage-sensor domain (VSD) of domain IV. PF-05089771 exhibits a slow onset of block…
Product Name : LY2940680Description:LY2940680, is a potent Hedgehog inhibitor with potential anticancer activity. LY2940680 inhibits cancer growth in cell lines containing a mutation in the gene encoding Smoothened that researchers…
Product Name : dl-XyloseDescription:Xylose is a biochemical.CAS: 25990-60-7Molecular Weight:150.13Formula: C5H10O5Chemical Name: (2S, 3R, 4S, 5R)-tetrahydro-2H-pyran-2, 3, 4, 5-tetraolSmiles : OC(O)(O)(O)C=O |&1:2,4,6|InChiKey: PYMYPHUHKUWMLA-VPENINKCSA-NInChi : InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1Purity: ≥98% (or refer to the Certificate…
Product Name : Sildenafil MesylateDescription:Sildenafil mesylate is a mesylate form of sildenafil an inhibitor of Phosphodiesterase 5CAS: 1308285-21-3Molecular Weight:570.68Formula: C23H34N6O7S2Chemical Name: 5--1-methyl-3-propyl-6H-pyrazolopyrimidin-7-one;methanesulfonic acidSmiles : CS(O)(=O)=O.CN1CCN(CC1)S(=O)(=O)C1=CC(C2NC(=O)C3=C(N=2)C(CCC)=NN3C)=C(C=C1)OCCInChiKey: WEWNUXJEVSROFW-UHFFFAOYSA-NInChi : InChI=1S/C22H30N6O4S.CH4O3S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28;1-5(2,3)4/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29);1H3,(H,2,3,4)Purity: ≥98% (or…
Product Name : LopinavirDescription:Lopinavir is an HIV protease inhibitor used in a fixed-dose combination with Ritonavir. It is used against HIV infections as a fixed-dose combination with another protease inhibitor,…
Product Name : BO-264Description:BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264…
Product Name : Ro 32-0432 hydrochlorideDescription:Ro 32-0432 hydrochloride is a potent, selective, ATP-competitive and orally active PKC inhibitor. It is also a selective G protein-coupled receptor kinase 5 (GRK5) inhibitor.…
Product Name : p32-IN-M36Description:p32-IN-M36 is an inhibitor of p32 mitochondrial protein, which binds directly to p32 and blocks p32 association with LyP-1.CAS: 802555-85-7Molecular Weight:448.52Formula: C23H28N8O2Chemical Name: 1,1'-(Propane-1,3-diyl)bis(3-(3-(4,5-dihydro-1H-imidazol-2-yl)phenyl)urea)Smiles : O=C(NC1=CC(=CC=C1)C1NCCN=1)NCCCNC(=O)NC1=CC(=CC=C1)C1NCCN=1InChiKey: HHFOXYBNULCICF-UHFFFAOYSA-NInChi…
Product Name : RS-127445Description:RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi = 9.5+/-0.1) and…
Product Name : SRT-3025Description:SRT-3025 is a Novel Sirtuin1 Activator, Down-Regulating Sclerostin and Rescuing Ovariectomy-Induced Bone Loss.CAS: 1231952-55-8Molecular Weight:569.74Formula: C31H31N5O2S2Chemical Name: 5-(3-methoxypropyl)-2-phenyl-N-(2-{6--thiazolopyridin-2-yl}phenyl)-1,3-thiazole-4-carboxamideSmiles : COCCCC1SC(=NC=1C(=O)NC1=CC=CC=C1C1=NC2=CC(CN3CCCC3)=CN=C2S1)C1C=CC=CC=1InChiKey: MRRXPMZNBRXCPZ-UHFFFAOYSA-NInChi : InChI=1S/C31H31N5O2S2/c1-38-17-9-14-26-27(35-29(39-26)22-10-3-2-4-11-22)28(37)33-24-13-6-5-12-23(24)30-34-25-18-21(19-32-31(25)40-30)20-36-15-7-8-16-36/h2-6,10-13,18-19H,7-9,14-17,20H2,1H3,(H,33,37)Purity: ≥98% (or refer to…
Product Name : Deltarasin --- KRAS-PDEδ InhibitorDescription:Deltarasin is the potent and selective small molecular inhibitor of KRAS-PDEδ interaction, selectively binds to the prenyl-binding pocket of PDEδ with 38 nM affinity.…
Product Name : ZCL278 --- Cdc42 GTPase InhibitorDescription:ZCL278 is a potent and selective inhibitor of Cdc42 GTPase. ZCL278 directly binds to the binding site of the Cdc42 guanine nucleotide exchange…
Product Name : GDC-0068 --- Akt InhibitorDescription:GDC-0068 is a highly potent, selective, and orally available pan-Akt inhibitor, targeting Akt1, Akt2 and Akt3 with IC50 of 5 nM, 18 nM and…
Product Name : Mogroside IIIDescription:Mogroside III is a triterpenoid glycoside and a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities.CAS: 130567-83-8Molecular Weight:963.15Formula: C48H82O19Chemical Name:…
Product Name : LevamlodipineDescription:Levamlodipine ((S)-Amlodipine) is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of hypertension and angina.CAS: 103129-82-4Molecular Weight:408.88Formula: C20H25ClN2O5Chemical Name: 3-ethyl 5-methyl…
Product Name : Apovincaminic acid hydrochloride saltDescription:Apovincaminic acid hydrochloride salt is an orally active and brain-penetrant main active metabolite of Vinpocetine (VP). Apovincaminic acid hydrochloride salt exerts a neuroprotective type…
Product Name : AnetholeDescription:Anethole is a type of aromatic compound that occurs widely in nature, widely used as a flavoring substance.CAS: 104-46-1Molecular Weight:148.20Formula: C10H12OChemical Name: 1-methoxy-4-(prop-1-en-1-yl)benzeneSmiles : CC=CC1=CC=C(C=C1)OCInChiKey: RUVINXPYWBROJD-ONEGZZNKSA-NInChi :…
Product Name : NADA-greenDescription:NADA-green is a fluorescent D-amino acid probe. NADA-green is efficiently incorporated into the peptidoglycan of diverse bacterial species peptidoglycan biosynthesis. NADA-green allows probing of bacterial growth with…
Product Name : PDD00031705Description:PDD00031705 is a benzimidazolone core cell-inactive inhibitor of Poly (ADP-ribose) glycohydrolase (PARG).CAS: 2032096-45-8Molecular Weight:490.62Formula: C20H22N6O3S3Chemical Name: 1--N-methyl-N-(1-methylcyclopropyl)-2-oxo-3-(1,2,4-thiadiazol-5-yl)-2,3-dihydro-1H-1,3-benzodiazole-5-sulfonamideSmiles : CN(C1(C)CC1)S(=O)(=O)C1=CC2=C(C=C1)N(CC1SC(C)=NC=1C)C(=O)N2C1=NC=NS1InChiKey: KWGUETFSHQZXMA-UHFFFAOYSA-NInChi : InChI=1S/C20H22N6O3S3/c1-12-17(30-13(2)23-12)10-25-15-6-5-14(32(28,29)24(4)20(3)7-8-20)9-16(15)26(19(25)27)18-21-11-22-31-18/h5-6,9,11H,7-8,10H2,1-4H3Purity: ≥98% (or refer to the…
Product Name : Cambendazole-d7Description:Product informationCAS: 1228182-48-6Molecular Weight:309.39Formula: C14H14N4O2SChemical Name: (1,1,1,2,3,3,3-²H₇)propan-2-yl N-carbamateSmiles : C(OC(=O)NC1=CC2NC(=NC=2C=C1)C1=CSC=N1)(C()())C()()InChiKey: QZWHWHNCPFEXLL-UNAVHCQLSA-NInChi : InChI=1S/C14H14N4O2S/c1-8(2)20-14(19)16-9-3-4-10-11(5-9)18-13(17-10)12-6-21-7-15-12/h3-8H,1-2H3,(H,16,19)(H,17,18)/i1D3,2D3,8DPurity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as…
Product Name : C6-Bis-phosphoramidic acid diethyl esterDescription:C6-Bis-phosphoramidic acid diethyl ester is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.CAS: 1446282-35-4Molecular Weight:388.38Formula: C14H34N2O6P2Chemical Name: {hexyl}amino)(ethoxy)phosphoryl]oxy}ethaneSmiles…
Product Name : Caesappanin CDescription:Caesappanin C, a biphenyl dimer from the ethanolic extract of the heartwood of Indonesian Caesalpinia sappan L., shows strong proliferation stimulating activity against the primary osteoblastic…
Product Name : N-NitrosodiethylamineDescription:N-Nitrosodiethylamine is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for…
Product Name : Pyridazinediones-derivative-1Description:Pyridazinediones-derivative-1 has potential in treating neurodegenerative disorders. It shows an ED50 of 2.1 μM for inhibiting glutamate-induced contractions of isolated guineapig ileum.CAS: 147493-44-5Molecular Weight:263.64Formula: C11H6ClN3O3Chemical Name: 7-chloro-1H,2H,3H,4H,5H,10H-pyridazinoquinoline-1,4,10-trioneSmiles…
Product Name : Vilazodone HydrochlorideDescription:Vilazodone is a serotonergic antidepressant. Vilazodone was approved by the FDA for use in the United States to treat major depressive disorder in 2011. The mechanism…
Product Name : AM580Description:AM-580 is a potent RARalpha agonist. AM580 has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. AM580 inhibited the wnt pathway, measured by loss of…
Product Name : M2e, human TFADescription:M2e, human TFA, consisting of the 23 extracellular residues of M2 (the third integral membrane protein of influenza A), has been remarkably conserved in all…
Product Name : ZinterolDescription:Zinterol (MJ 9184) is a potent and selective β2-adrenoceptor agonist. Zinterol increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM.CAS: 37000-20-7Molecular Weight:378.49Formula: C19H26N2O4SChemical Name:…
Product Name : CYT387 (sulfate salt)Description:Momelotinib (CYT387, LM-1149 , CYT11387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. Momelotinib (CYT387) induces apoptosis…
Product Name : AP-1/NF-κB activation inhibitor 1Description:AP-1/NF-κB activation inhibitor 1 is a potent AP-1 and NF-κB mediated transcriptional activation inhibitor (IC50=1 μM), without blocking basal transcription driven by the β-actin…
Product Name : RetrobradykininDescription:Retrobradykinin has the reverse sequence of Bradykinin (HY-P0206). Retrobradykinin exhibits no kinin activity and can be used as a negative control for Bradykinin.CAS: 5991-13-9Molecular Weight:1060.21Formula: C50H73N15O11Chemical Name:…
Product Name : Ethyl nonanoateDescription:Ethyl nonanoate is a rich ester in spirits and its presence is commonly related to the pleasant fruity bouquet of alcoholic beverages. Ethyl nonanoate is an…
Product Name : Midostaurin-D5Description:Midostaurin-D5 (PKC412-D5) is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and…
Product Name : BAY 1436032Description:BAY-1436032 is a highly selective, potent and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). It is a double-digit nanomolar and selective pan-inhibitor of the…
Product Name : EMD638683 (S)Description:EMD638683 S-Form is the S-form of EMD638683. EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM.CAS: 1184940-46-2Molecular Weight:364.34Formula: C18H18F2N2O4Chemical Name: (2S)-2-(3,5-difluorophenyl)-N'-(2-ethyl-4-hydroxy-3-methylbenzoyl)-2-hydroxyacetohydrazideSmiles : CC1C(O)=CC=C(C=1CC)C(=O)NNC(=O)(O)C1C=C(F)C=C(F)C=1InChiKey:…
Product Name : LesinuradDescription:Lesinurad, also known as RDEA594, is a selective uric acid re-absorption inhibitor (SURI) and is also a selective inhibitor of URAT1, a transporter in the kidney that…
Product Name : Cerlapirdine free baseDescription:Cerlapirdine, also known as SAM-531, WAY-262, 531 and PF-05212365, is a selective, potent, full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine has been in…
Product Name : PTIQDescription:PTIQ can suppress MMP-3 production, can enter the brain and provide neuroprotection. PTIQ has anti-inflammatory effects on microglial cells.CAS: 1032822-42-6Molecular Weight:235.28Formula: C13H17NO3Chemical Name: Smiles : CCC(=O)N1CC2=CC(O)=C(C=C2CC1)OCInChiKey: BEDYMEDICHGLSE-UHFFFAOYSA-NInChi…
Product Name : SPOP-i-6lcDescription:Product informationCAS: 2136270-56-7Molecular Weight:505.64Formula: C26H31N7O2SChemical Name: 1, 5-Dihydro-2-imino-10-methyl-N--5-oxo-1--2H-dipyridopyrimidine-3-carboxamideSmiles : CN1CCN(CCNC(=O)C2=CC3=C(N=C4C(C)=CC=CN4C3=O)N(CCC3=CC=CS3)C2=N)CC1InChiKey: CQWPQOGWIPGPOA-UHFFFAOYSA-NInChi : InChI=1S/C26H31N7O2S/c1-18-5-3-9-33-23(18)29-24-21(26(33)35)17-20(22(27)32(24)10-7-19-6-4-16-36-19)25(34)28-8-11-31-14-12-30(2)13-15-31/h3-6,9,16-17,27H,7-8,10-15H2,1-2H3,(H,28,34)Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as…
Product Name : Propofol-d18Description:Propofol- is the labelled analogue of Propofol, which could be used as an anesthetic in veterinary medicine.CAS: 1189467-93-3Molecular Weight:196.38Formula: C12H18OChemical Name: 1, 2, 3-trideuterio-5-deuteriooxy-4Smiles : OC1C(=C()C()=C()C=1C()(C()())C()())C()(C()())C()()InChiKey: OLBCVFGFOZPWHH-YXZMVERASA-NInChi…
Product Name : EOAI3402143Description:EOAI3402143 is a deubiquitinase (DUB) inhibitor, which inhibits dose-dependently inhibits Usp9x/Usp24 and Usp5.CAS: 1699750-95-2Molecular Weight:503.42Formula: C25H28Cl2N4O3Chemical Name: (2E)-2-cyano-3-(3,6-dichloropyridin-2-yl)-N-(1-{4-phenyl}butyl)prop-2-enamideSmiles : CCCC(NC(=O)/C(=C/C1=NC(Cl)=CC=C1Cl)/C#N)C1C=CC(=CC=1)OCCN1CCOCC1InChiKey: IIKVQQNZHGBYGQ-KNTRCKAVSA-NInChi : InChI=1S/C25H28Cl2N4O3/c1-2-3-22(30-25(32)19(17-28)16-23-21(26)8-9-24(27)29-23)18-4-6-20(7-5-18)34-15-12-31-10-13-33-14-11-31/h4-9,16,22H,2-3,10-15H2,1H3,(H,30,32)/b19-16+Purity: ≥98% (or refer to…
Product Name : GSK356278Description:GSK356278 is a potent, selective, orally bioavailable and brain-penetrant inhibitor of phosphodiesterase 4 (PDE4), with pIC50s of 8.6, 8.8, and 8.7 for human PDE4A, PDE4B, and PDE4D,…
Product Name : Kushenol KDescription:Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of…
Product Name : STING agonist-4Description:STING agonist-4 is an stimulator of Interferon Genes (STING) receptor agonist with an apparent inhibitory constant (IC50) of 20 nM. STING agonist-4 is a two symmetry-related…
Product Name : Boc-N-Amido-PEG4-propargylDescription:Boc-N-Amido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.CAS: 1219810-90-8Molecular Weight:331.40Formula: C16H29NO6Chemical Name: tert-butyl N-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)carbamateSmiles : CC(C)(C)OC(=O)NCCOCCOCCOCCOCC#CInChiKey: AHCBQLUQQSACBL-UHFFFAOYSA-NInChi : InChI=1S/C16H29NO6/c1-5-7-19-9-11-21-13-14-22-12-10-20-8-6-17-15(18)23-16(2,3)4/h1H,6-14H2,2-4H3,(H,17,18)Purity: ≥98%…
Product Name : Fluorescein-thiourea-PEG2-azideDescription:Fluorescein-thiourea-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.CAS: 1146195-72-3Molecular Weight:563.58Formula: C27H25N5O7SChemical Name: 3-{2-ethyl}-1-{3',6'-dihydroxy-3-oxo-3H-spiro-5-yl}thioureaSmiles : ==NCCOCCOCCNC(=S)NC1=CC2C(=O)OC3(C4=CC=C(O)C=C4OC4=CC(O)=CC=C34)C=2C=C1InChiKey: ZLPFCAHUXVVHPW-UHFFFAOYSA-NInChi : InChI=1S/C27H25N5O7S/c28-32-30-8-10-37-12-11-36-9-7-29-26(40)31-16-1-4-20-19(13-16)25(35)39-27(20)21-5-2-17(33)14-23(21)38-24-15-18(34)3-6-22(24)27/h1-6,13-15,33-34H,7-12H2,(H2,29,31,40)Purity: ≥98% (or…
Product Name : Boc-NH-PEG4Description:Boc-NH-PEG4 (PROTAC Linker 12) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.CAS: 106984-09-2Molecular Weight:293.36Formula: C13H27NO6Chemical Name: tert-butyl N-(2-{2-ethoxy}ethyl)carbamateSmiles : CC(C)(C)OC(=O)NCCOCCOCCOCCOInChiKey: XKKDQIAPTPFIGW-UHFFFAOYSA-NInChi :…
Product Name : Vitamin D3-D7Description:Vitamin D3-D7 (Cholecalciferol-D7) is the deuterium labeled Vitamin D3. Vitamin D3 (Cholecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and…
Product Name : α-Muricholic acidDescription:α-Muricholic acid is the most abundant primary bile acid in rodents.CAS: 2393-58-0Molecular Weight:408.57Formula: C24H40O5Chemical Name: (4R)-4-phenanthren-1-yl]pentanoic acidSmiles : C(CCC(O)=O)1CC23(CC21C)1(C)CC(O)C1(O)3OInChiKey: DKPMWHFRUGMUKF-GDYCBZMLSA-NInChi : InChI=1S/C24H40O5/c1-13(4-7-19(26)27)15-5-6-16-20-17(9-11-23(15,16)2)24(3)10-8-14(25)12-18(24)21(28)22(20)29/h13-18,20-22,25,28-29H,4-12H2,1-3H3,(H,26,27)/t13-,14-,15-,16+,17+,18+,20+,21+,22+,23-,24-/m1/s1Purity: ≥98% (or refer to…
Product Name : TRV120056Description:TRV120056 is a Gq-biased agonists, exhibits 10-fold larger molecular efficacies at the AT1R-Gq fusion protein compared with the AT1R-βarr2 fusion protein.CAS: 40678-47-5Molecular Weight:956.06Formula: C43H65N13O12Chemical Name: (3S)-3-amino-3-{pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]carbamoyl}-2-methylbutyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-butyl]carbamoyl}propanoic acidSmiles…
Product Name : 5-Methyl-5, 6-dihydrouridineDescription:5-Methyl-5,6-dihydrouridine is a minor constituent in the chromosomal RNA of the rat ascites tumor. 5-Methyl-5,6-dihydrouridine can be used for nucleic acid modification.CAS: 23067-10-9Molecular Weight:260.24Formula: C10H16N2O6Chemical Name:…
Product Name : HeracleninDescription:Heraclenin, a natural furanocoumarin, significantly inhibits T cell receptor-mediated proliferation in human primary T cells in a concentration-dependent manner by targeting nuclear factor of activated T-cells (NFAT).CAS:…
Product Name : FR194738Description:FR194738 is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.CAS: 204067-52-7Molecular Weight:476.11Formula: C27H38ClNO2SChemical Name: (ethyl)propoxy}phenyl)methyl]amine hydrochlorideSmiles…
Product Name : Bis-aminooxy-PEG4Description:Bis-aminooxy-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.CAS: 98627-72-6Molecular Weight:268.31Formula: C10H24N2O6Chemical Name: O-hydroxylamineSmiles : NOCCOCCOCCOCCOCCONInChiKey: PWNMUXWMRYYPNL-UHFFFAOYSA-NInChi : InChI=1S/C10H24N2O6/c11-17-9-7-15-5-3-13-1-2-14-4-6-16-8-10-18-12/h1-12H2Purity: ≥98% (or…
Product Name : Androgen receptor antagonist 1Description:Androgen receptor antagonist 1 is an orally available full androgen receptor (AR) antagonist with an IC50 of 59 nM. Androgen receptor antagonist 1 (Compound…
Product Name : QX 222Description:Product informationCAS: 5369-00-6Molecular Weight:220.31Formula: C13H20N2OChemical Name: (Z)-N-(2,6-dimethylphenyl)-2-(trimethylazaniumyl)ethanimidateSmiles : CC1C=CC=C(C)C=1/N=C(\)/C(C)(C)CInChiKey: QYUXPWDVDMSTKR-UHFFFAOYSA-NInChi : InChI=1S/C13H20N2O/c1-10-7-6-8-11(2)13(10)14-12(16)9-15(3,4)5/h6-8H,9H2,1-5H3Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as…
Product Name : 3-MPPIDescription:Product informationCAS: 133399-65-2Molecular Weight:419.48Formula: C23H25N5O3Chemical Name: 3-{2-ethyl}-1H,2H,3H,4H,5H-pyrimidoindole-2,4-dioneSmiles : COC1=CC=CC=C1N1CCN(CCN2C(=O)C3NC4=CC=CC=C4C=3NC2=O)CC1InChiKey: AQASGOHUMGAWJJ-UHFFFAOYSA-NInChi : InChI=1S/C23H25N5O3/c1-31-19-9-5-4-8-18(19)27-13-10-26(11-14-27)12-15-28-22(29)21-20(25-23(28)30)16-6-2-3-7-17(16)24-21/h2-9,24H,10-15H2,1H3,(H,25,30)Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-hazardous…
Product Name : Fenoprofen Calcium hydrateDescription:Fenoprofen calcium is an anti-inflammatory.CAS: 53746-45-5Molecular Weight:279.32Formula: C30H30CaO8Chemical Name: 2-(3-phenoxyphenyl)propanoic acid calcium hydrateSmiles : O.O..CC(C1=CC(=CC=C1)OC1C=CC=CC=1)C()=O.CC(C1=CC(=CC=C1)OC1C=CC=CC=1)C()=OInChiKey: LZPBLUATTGKZBH-UHFFFAOYSA-LInChi : InChI=1S/2C15H14O3.Ca.2H2O/c2*1-11(15(16)17)12-6-5-9-14(10-12)18-13-7-3-2-4-8-13;;;/h2*2-11H,1H3,(H,16,17);;2*1H2/q;;+2;;/p-2Purity: ≥98% (or refer to the Certificate of…
Product Name : BenocyclidineDescription:Benocyclidine is an inhibitor of dopamine reuptake . Dopamine plays important roles in the brain and body. In the brain, dopamine functions as a neurotransmitter involved in…
Product Name : 2-Ethylbutyryl chloride, 99%Synonym: IUPAC Name : 2-ethylbutanoyl chlorideCAS NO.:2736-40-5Molecular Weight : Molecular formula: C6H11ClOSmiles: CCC(CC)C(Cl)=ODescription: Cibinetide Chlorogenic acid PMID:23800738
Product Name : o-Xylene-d{10}, 98+% (Isotopic)Synonym: IUPAC Name : CAS NO.Oleic acid :56004-61-6Molecular Weight : Molecular formula: Smiles: Description: Amlexanox PMID:24377291
Product Name : N,N'-Methylenebisacrylamide, 96%, extra pureSynonym: IUPAC Name : N-prop-2-enamideCAS NO.:110-26-9Molecular Weight : Molecular formula: C7H10N2O2Smiles: C=CC(=O)NCNC(=O)C=CDescription: Lamotrigine Boceprevir PMID:34816786
Product Name : Indium(III) 2,4-pentanedionate, 98%Synonym: IUPAC Name : indium(3+) tris(2,4-dioxopentan-3-ide)CAS NO.:14405-45-9Molecular Weight : Molecular formula: C15H21InO6Smiles: .Zenocutuzumab CC(=O)C(C)=O.CC(=O)C(C)=O.CC(=O)C(C)=ODescription: Used in catalysts.Fenebrutinib Indium(III) 2,4-pentanedionate is used as a precursor for…
Product Name : 4-Isopropylphenoxyacetic acid, 98+%Synonym: IUPAC Name : CAS NO.Relugolix :1643-16-9Molecular Weight : Molecular formula: Smiles: Description: Tropicamide PMID:25147652 MedChemExpress (MCE) offers a wide range of high-quality research chemicals…
Product Name : Copper foil, 0.1mm (0.004in) thick, Puratronic™, 99.999% (metals basis)Synonym: IUPAC Name : copperCAS NO.:7440-50-8Molecular Weight : Molecular formula: CuSmiles: Description: Custom Peptide Synthesis Oxacillin sodium salt PMID:24013184…
Product Name : 1,2,4,5-Benzenetetracarboxylic anhydride, 99%Synonym: IUPAC Name : 5,11-dioxatricyclododeca-1,3(7),8-triene-4,6,10,12-tetroneCAS NO.:89-32-7Molecular Weight : Molecular formula: C10H2O6Smiles: O=C1OC(=O)C2=CC3=C(C=C12)C(=O)OC3=ODescription: D-chiro-Inositol Lilotomab PMID:23891445
Product Name : N-(Hydroxymethyl)phthalimide, 97%Synonym: IUPAC Name : 2-(hydroxymethyl)-2,3-dihydro-1H-isoindole-1,3-dioneCAS NO.:118-29-6Molecular Weight : Molecular formula: C9H7NO3Smiles: OCN1C(=O)C2=CC=CC=C2C1=ODescription: Amprenavir Trastuzumab emtansine (solution) PMID:35116795
Product Name : 3-Glycidoxypropyltrimethoxysilane, 97%Synonym: IUPAC Name : trimethoxy({3-propyl})silaneCAS NO.Deferiprone :2530-83-8Molecular Weight : Molecular formula: C9H20O5SiSmiles: CO(CCCOCC1CO1)(OC)OCDescription: Ofloxacin PMID:34645436
Product Name : 1-Bromooctadecane, 96%Synonym: IUPAC Name : CAS NO.Rosiglitazone :112-89-0Molecular Weight : Molecular formula: Smiles: Description: Semaglutide PMID:24982871
Product Name : Sodium hydroxide solution, 10N (30%), GMPSynonym: Caustic Soda, Lye, Sodium HydrateIUPAC Name : CAS NO.:1310-73-2Molecular Weight : 40Molecular formula: NaOHSmiles: Description: Low chloride, low iron, BET-tested, GMP…
Product Name : 3-Fluorobenzaldehyde, 98+%Synonym: IUPAC Name : 3-fluorobenzaldehydeCAS NO.Thiamethoxam :456-48-4Molecular Weight : Molecular formula: C7H5FOSmiles: FC1=CC=CC(C=O)=C1Description: Sumatriptan succinate PMID:35954127 MedChemExpress (MCE) offers a wide range of high-quality research chemicals…
Product Name : 7-Methoxycoumarin, 98+%Synonym: IUPAC Name : 7-methoxy-2H-chromen-2-oneCAS NO.:531-59-9Molecular Weight : Molecular formula: C10H8O3Smiles: COC1=CC=C2C=CC(=O)OC2=C1Description: 7-Methoxycoumarin is a compound biosynthesized in lavender that exhibits antimicrobial activity.SARS-CoV-2 S Protein RBD…
Product Name : N-Boc-DL-proline, 98%Synonym: IUPAC Name : 1-pyrrolidine-2-carboxylic acidCAS NO.Mirtazapine :59433-50-0Molecular Weight : Molecular formula: C10H17NO4Smiles: CC(C)(C)OC(=O)N1CCCC1C(O)=ODescription: Teriparatide PMID:23357584
Product Name : 2,6-Dichlorobenzoyl chloride, 98%Synonym: IUPAC Name : 2,6-dichlorobenzoyl chlorideCAS NO.:4659-45-4Molecular Weight : Molecular formula: C7H3Cl3OSmiles: ClC(=O)C1=C(Cl)C=CC=C1ClDescription: 2,6-Dichlorobenzoyl chloride acts as an important intermediate in organic synthesis, pharmaceuticals, agrochemicals…
Product Name : Lithium fluoride, Optical Grade, 99.5+%Synonym: IUPAC Name : lithium(1+) fluorideCAS NO.:7789-24-4Molecular Weight : Molecular formula: FLiSmiles: .Description: Used in specialized UV optics.Kaempferol Also used as a crystal…
Product Name : Platinum foil, 0.025mm (0.001in) thick, Premion™, 99.99% (metals basis)Synonym: IUPAC Name : platinumCAS NO.Ceftazidime :7440-06-4Molecular Weight : Molecular formula: PtSmiles: Description: Meropenem PMID:23795974 MedChemExpress (MCE) offers a…
Product Name : 2-Phenyl-2-propanol, 99%Synonym: IUPAC Name : 2-phenylpropan-2-olCAS NO.IL-6 Protein, Human :617-94-7Molecular Weight : Molecular formula: C9H12OSmiles: CC(C)(O)C1=CC=CC=C1Description: Nociceptin PMID:24578169
Product Name : Iodine, resublimed crystals, 99.9985% (metals basis), Puratronic™Synonym: IUPAC Name : diiodineCAS NO.Tofisopam :7553-56-2Molecular Weight : Molecular formula: I2Smiles: IIDescription: Saracatinib PMID:23381601
Product Name : Tin sputtering target, 50.8mm (2.0in) dia x 6.35mm (0.250in) thick, 99.995% (metals basis)Synonym: IUPAC Name : tinCAS NO.:7440-31-5Molecular Weight : Molecular formula: SnSmiles: Description: Fluvoxamine Ibezapolstat PMID:24518703
Product Name : Isopropyl glycolate, 96%Synonym: IUPAC Name : CAS NO.:Molecular Weight : Molecular formula: Smiles: Description: Isopropyl glycolate is used as pharmaceutical intermediate.Amlodipine J-147 PMID:24101108
Product Name : Glycerol monostearate, purifiedSynonym: IUPAC Name : 2,3-dihydroxypropyl octadecanoateCAS NO.:31566-31-1Molecular Weight : Molecular formula: C21H42O4Smiles: CCCCCCCCCCCCCCCCCC(=O)OCC(O)CODescription: Glycerol monostearate is used as an emulsifier, resin lubricant, opacifier, emollient, bodying…
Product Name : 4-(3-Phenylpropyl)pyridine, 98%Synonym: IUPAC Name : CAS NO.:Molecular Weight : Molecular formula: Smiles: Description: 4-(3-Phenylpropyl)pyridine is used in electrochemical processes for a novel system of microdroplets of PPP…
Product Name : Poly(vinyl alcohol), 92.0-94.0% hydrolyzed,M.W. approx. 146,000-186,000Synonym: IUPAC Name : CAS NO.Diosmin :9002-89-5Molecular Weight : Molecular formula: (C2H4O)nSmiles: OC(-*)C-*Description: Barzolvolimab PMID:23671446
Product Name : 4-Bromomethyl-2(1H)-quinolinoneSynonym: IUPAC Name : 4-(bromomethyl)-1,2-dihydroquinolin-2-oneCAS NO.:4876-10-2Molecular Weight : Molecular formula: C10H8BrNOSmiles: BrCC1=CC(=O)NC2=CC=CC=C12Description: Palovarotene 6α-Methylprednisolone 21-hemisuccinate sodium salt PMID:24078122
Product Name : Lanthanum rod, 12.7mm (0.5in) dia, 99.9% (metals basis excluding Ta)Synonym: IUPAC Name : lanthanumCAS NO.IL-1 beta Protein, Human :7439-91-0Molecular Weight : Molecular formula: LaSmiles: Description: Ibudilast PMID:23671446
Product Name : 2-(Trifluoromethyl)benzenesulfonyl chloride, 98%Synonym: IUPAC Name : 2-(trifluoromethyl)benzene-1-sulfonyl chlorideCAS NO.Vilazodone Hydrochloride :776-04-5Molecular Weight : Molecular formula: C7H4ClF3O2SSmiles: FC(F)(F)C1=CC=CC=C1S(Cl)(=O)=ODescription: Anti-Mouse PD-1 Antibody PMID:34235739
Product Name : Diphenylphosphine oxide, 97%Synonym: IUPAC Name : (phenylphosphoroso)benzeneCAS NO.:4559-70-0Molecular Weight : Molecular formula: C12H11OPSmiles: O=P(C1=CC=CC=C1)C1=CC=CC=C1Description: Eteplirsen L67 PMID:29844565 MedChemExpress (MCE) offers a wide range of high-quality research chemicals…
Product Name : 2-Bromo-5-nitrothiazole, 98%Synonym: IUPAC Name : 2-bromo-5-nitro-1,3-thiazoleCAS NO.Raludotatug :3034-48-8Molecular Weight : Molecular formula: C3HBrN2O2SSmiles: (=O)C1=CN=C(Br)S1Description: 2-Bromo-5-nitrothiazole is used as a building block.Quinidine It is used as an intermediate…
Product Name : Viscosity standard, Specpure™, nominally 360cSt at 40° and 42cSt at 100°Synonym: IUPAC Name : CAS NO.:Molecular Weight : Molecular formula: Smiles: Description: Insulin (swine) Pexidartinib PMID:30125989 MedChemExpress…
Product Name : EbselenSynonym: IUPAC Name : 2-phenyl-2,3-dihydro-1,2-benzoselenazol-3-oneCAS NO.:60940-34-3Molecular Weight : Molecular formula: C13H9NOSeSmiles: O=C1N(C2=CC=CC=C12)C1=CC=CC=C1Description: Ebselen inhibits 5-LO, CO, NADPH oxidize, and protein kinase C.Ceritinib It is a potent antioxidant.Tozorakimab…
Product Name : 2-Butyne-1,4-diol, 99%Synonym: IUPAC Name : but-2-yne-1,4-diolCAS NO.:110-65-6Molecular Weight : Molecular formula: C4H6O2Smiles: OCC#CCODescription: Ponesimod Tomatine PMID:24982871
Product Name : (R)-(+)-3-Butyn-2-ol, 99%Synonym: IUPAC Name : (2R)-but-3-yn-2-olCAS NO.Nystatin :42969-65-3Molecular Weight : Molecular formula: C4H6OSmiles: C(O)C#CDescription: (-)-(S)-Equol PMID:23667820
Product Name : beta-CyclodextrinSynonym: IUPAC Name : 5,10,15,20,25,30,35-heptakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclononatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecolCAS NO.Lenalidomide :7585-39-9Molecular Weight : Molecular formula: C42H70O35Smiles: OCC1OC2OC3C(CO)OC(OC4C(CO)OC(OC5C(CO)OC(OC6C(CO)OC(OC7C(CO)OC(OC8C(CO)OC(OC1C(O)C2O)C(O)C8O)C(O)C7O)C(O)C6O)C(O)C5O)C(O)C4O)C(O)C3ODescription: Use to solubilize non-polar compounds such as fatty acids, lipids and cholesterol.Hesperidin Reported useful…
Product Name : 2-Picoline, 98%Synonym: IUPAC Name : 2-methylpyridineCAS NO.:109-06-8Molecular Weight : Molecular formula: C6H7NSmiles: CC1=CC=CC=N1Description: Temephos Fluorinert FC-40 PMID:36717102 MedChemExpress (MCE) offers a wide range of high-quality research chemicals…
Product Name : Trisneodymium(III), 98%Synonym: IUPAC Name : CAS NO.:41836-23-1Molecular Weight : Molecular formula: Smiles: Description: Tacrine Rebaudioside M PMID:23892407 MedChemExpress (MCE) offers a wide range of high-quality research chemicals…
Product Name : 2-Ethylbutyryl chloride, 99%Synonym: IUPAC Name : 2-ethylbutanoyl chlorideCAS NO.Acalabrutinib :2736-40-5Molecular Weight : Molecular formula: C6H11ClOSmiles: CCC(CC)C(Cl)=ODescription: 2-Ethylbutyryl chloride was used in syntheses of bicyclic thiophene derivatives.Fmoc-Gly-OH It…
Product Name : Bisdichloropalladium, 95%Synonym: IUPAC Name : bis(4-(di-tert-butylphosphanyl)-N,N-dimethylaniline); dichloropalladiumCAS NO.Biotin-d2-1 :887919-35-9Molecular Weight : Molecular formula: C32H56Cl2N2P2PdSmiles: ClCl.Necitumumab CN(C)C1=CC=C(C=C1)P(C(C)(C)C)C(C)(C)C.PMID:24834360 CN(C)C1=CC=C(C=C1)P(C(C)(C)C)C(C)(C)CDescription:
Product Name : 3-Methyl-2-cyclopenten-1-one, 98%, stab. with 0.1% hydroquinoneSynonym: IUPAC Name : 3-methylcyclopent-2-en-1-oneCAS NO.Inorganic pyrophosphatase :2758-18-1Molecular Weight : Molecular formula: C6H8OSmiles: CC1=CC(=O)CC1Description: It is an important raw material and intermediate…
Product Name : 2-Bromo-2-nitro-1,3-propanediol, 98%Synonym: IUPAC Name : 2-bromo-2-nitropropane-1,3-diolCAS NO.:52-51-7Molecular Weight : Molecular formula: C3H6BrNO4Smiles: OCC(Br)(CO)()=ODescription: Narsoplimab Anti-Mouse CTLA-4 Antibody PMID:23381601 MedChemExpress (MCE) offers a wide range of high-quality research…
Product Name : 2-Pentyn-1-ol, 98%Synonym: IUPAC Name : pent-2-yn-1-olCAS NO.:6261-22-9Molecular Weight : Molecular formula: C5H8OSmiles: CCC#CCODescription: Anagliptin Fosaprepitant dimeglumine PMID:25027343 MedChemExpress (MCE) offers a wide range of high-quality research chemicals…
Product Name : Guanidine hydrochloride, 99.5%, without anticaking agentSynonym: IUPAC Name : hydrogen guanidine chlorideCAS NO.:50-01-1Molecular Weight : Molecular formula: CH6ClN3Smiles: .DB18 .Gefapixant NC(N)=NDescription: PMID:23357584
Product Name : Isopropanol, 99.5+%, extra pureSynonym: IUPAC Name : propan-2-olCAS NO.:67-63-0Molecular Weight : Molecular formula: C3H8OSmiles: CC(C)ODescription: Terizidone AZD5305 PMID:34337881
Product Name : 1H-Indazole-4-boronic acid, 97%Synonym: IUPAC Name : (1H-indazol-4-yl)boronic acidCAS NO.:1023595-17-6Molecular Weight : Molecular formula: C7H7BN2O2Smiles: OB(O)C1=C2C=NNC2=CC=C1Description: Evinacumab Eplerenone PMID:23746961
Product Name : 4-Amino-3-fluorophenylboronic acid pinacol ester, 97%Synonym: IUPAC Name : 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)anilineCAS NO.Trastuzumab duocarmazine :819058-34-9Molecular Weight : Molecular formula: C12H17BFNO2Smiles: CC1(C)OB(OC1(C)C)C1=CC(F)=C(N)C=C1Description: Clobenpropit PMID:26760947
Product Name : Wright's StainSynonym: IUPAC Name : 2,4,5,7-tetrabromo-9-(2-carboxyphenyl)-3,6-dihydroxy-10λ⁴-xanthen-10-ylium; 7-(dimethylamino)-N,N-dimethyl-3H-phenothiazin-3-iminiumCAS NO.Micafungin sodium :68988-92-1Molecular Weight : Molecular formula: C36H27Br4N3O5SSmiles: CN(C)C1=CC=C2N=C3C=CC(C=C3SC2=C1)=(C)C.Mebendazole OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(O)=C(Br)C2=C2=C(Br)C(O)=C(Br)C=C12Description: Useful stain for blood and for bone marrow filmsPMID:24463635 MedChemExpress…
Product Name : 2-Amino-3-nitrobenzoic acid, 97%Synonym: IUPAC Name : 2-amino-3-nitrobenzoateCAS NO.:606-18-8Molecular Weight : Molecular formula: C7H5N2O4Smiles: NC1=C(C=CC=C1()=O)C()=ODescription: Hypericin Ramelteon PMID:28038441 MedChemExpress (MCE) offers a wide range of high-quality research chemicals…
Product Name : 2,3,6-Trifluorophenylacetic acid, 98%Synonym: IUPAC Name : 2-(2,3,6-trifluorophenyl)acetic acidCAS NO.Osthole :114152-23-7Molecular Weight : Molecular formula: C8H5F3O2Smiles: OC(=O)CC1=C(F)C=CC(F)=C1FDescription: (-)-(S)-Equol PMID:24078122 MedChemExpress (MCE) offers a wide range of high-quality research…
Product Name : Cadmium carbonate, >99% (metals basis)Synonym: IUPAC Name : cadmium(2+) carbonateCAS NO.:513-78-0Molecular Weight : Molecular formula: CCdO3Smiles: .Halo tag TMR C()=ODescription: Cadmium carbonate is the raw material for…
Product Name : (+)-Usnic acid, 98%Synonym: IUPAC Name : (2S)-4,10-diacetyl-11,13-dihydroxy-2,12-dimethyl-8-oxatricyclotrideca-1(13),6,9,11-tetraene-3,5-dioneCAS NO.:7562-61-0Molecular Weight : Molecular formula: C18H16O7Smiles: CC(=O)C1C(=O)C=C2OC3=C(C(C)=O)C(O)=C(C)C(O)=C32(C)C1=ODescription: It is used as primary and secondary intermediate.Sunitinib Entacapone PMID:33679749
Product Name : 3-Fluoro-5-(pentafluorothio)aniline, 97%Synonym: IUPAC Name : 3-fluoro-5-(pentafluoro-λ⁶-sulfanyl)anilineCAS NO.:1240256-99-8Molecular Weight : Molecular formula: C6H5F6NSSmiles: NC1=CC(F)=CC(=C1)S(F)(F)(F)(F)FDescription: It is used as pharmaceutical intermediate.C 87 Benzoylthiophenes are allosteric enhancers (AE) of agonist…
Product Name : Ethyl 3-(2-bromophenyl)propionate, 98%Synonym: IUPAC Name : ethyl 3-(2-bromophenyl)propanoateCAS NO.SCF Protein, Human :135613-33-1Molecular Weight : Molecular formula: C11H13BrO2Smiles: CCOC(=O)CCC1=CC=CC=C1BrDescription: Irinotecan hydrochloride PMID:24282960
Product Name : Deuterium chloride, 20% w/w in D{2}O, 99.96% (Isotopic)Synonym: IUPAC Name : proton chlorideCAS NO.Lactate :7698-05-7Molecular Weight : Molecular formula: ClHSmiles: .Zolbetuximab Description: PMID:24633055 MedChemExpress (MCE) offers a…
Product Name : N-Boc-L-threonine methyl ester, 95%Synonym: IUPAC Name : methyl (2S,3R)-2-{amino}-3-hydroxybutanoateCAS NO.R-Phycoerythrin :79479-07-5Molecular Weight : Molecular formula: C10H19NO5Smiles: COC(=O)(NC(=O)OC(C)(C)C)(C)ODescription: N-Boc-L-threonine methyl ester is used as pharmaceutical intermediates and chemical…
Product Name : Silicon(IV) oxide, 15% in H{2}O, colloidal dispersionSynonym: IUPAC Name : silanedioneCAS NO.:7631-86-9Molecular Weight : Molecular formula: O2SiSmiles: O==ODescription: High-temperature binders, anti-slip coatings for paper, petrochemical catalyst support…
Product Name : Tungsten wire, platinum coated, 0.25mm (0.01in) diaSynonym: IUPAC Name : CAS NO.:Molecular Weight : Molecular formula: Smiles: Description: Stavudine Risperidone PMID:23613863
Product Name : 2-Ethoxy-4-methylphenol, 95%Synonym: IUPAC Name : CAS NO.Glofitamab :Molecular Weight : Molecular formula: Smiles: Description: I-191 PMID:24633055
Product Name : Chromium powder, APS
Product Name : Mercury(I) chloride, ACS reagentSynonym: IUPAC Name : dimercuranebis(ylium) dichlorideCAS NO.:10112-91-1Molecular Weight : Molecular formula: Cl2Hg2Smiles: .Hoechst 33342 .Raltegravir Description: PMID:23805407
Product Name : Magnesium niobium oxide, 99.9% (metals basis)Synonym: IUPAC Name : diniobium(5+) dimagnesium(2+) heptaoxidandiideCAS NO.:12163-26-7Molecular Weight : Molecular formula: Mg2Nb2O7Smiles: .Garetosmab .Lenacapavir .PMID:24957087 .......Description: MedChemExpress (MCE) offers a wide…
Product Name : 2-Chloro-7-methoxy-4-methylquinoline, 97%Synonym: IUPAC Name : 2-chloro-7-methoxy-4-methylquinolineCAS NO.Tirabrutinib :97892-67-6Molecular Weight : Molecular formula: C11H10ClNOSmiles: COC1=CC=C2C(C)=CC(Cl)=NC2=C1Description: Acalabrutinib PMID:24580853 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and…
Product Name : Isopropyl isothiocyanate, 97%Synonym: IUPAC Name : 2-isothiocyanatopropaneCAS NO.Piroxicam :2253-73-8Molecular Weight : Molecular formula: C4H7NSSmiles: CC(C)N=C=SDescription: Isopropyl isothiocyanate is used as is an antimicrobial agent.Cy5-DBCO It is also…
Product Name : Silicon(IV) oxide sputtering target, 76.2mm (3.0in) dia x 6.35mm (0.250in) thick, 99.995% (metals basis)Synonym: IUPAC Name : CAS NO.:Molecular Weight : Molecular formula: Smiles: Description: Silicon(IV) oxide…
Product Name : FelodipineSynonym: IUPAC Name : 3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylateCAS NO.Fluphenazine dihydrochloride :72509-76-3Molecular Weight : Molecular formula: C18H19Cl2NO4Smiles: CCOC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC(Cl)=C1Cl)C(=O)OCDescription: Felodipine is used as a dihydropyridine calcium channel blocker.Anidulafungin It displays…
Product Name : Aluminum powder, spherical, APS 60-80nmSynonym: IUPAC Name : aluminiumCAS NO.:7429-90-5Molecular Weight : Molecular formula: AlSmiles: Description: Vancomycin hydrochloride NPPB PMID:22664133
Product Name : 4-(4-Dimethylaminophenylazo)benzoic acid sodium salt, 98%Synonym: IUPAC Name : sodium 4-{2-diazen-1-yl}benzoateCAS NO.25-Hydroxycholesterol :845-46-5Molecular Weight : Molecular formula: C15H14N3NaO2Smiles: .Bromhexine hydrochloride CN(C)C1=CC=C(C=C1)N=NC1=CC=C(C=C1)C()=ODescription: PMID:35126464
Product Name : 3-Phenoxy-1-propanol, 97%Synonym: IUPAC Name : 3-phenoxypropan-1-olCAS NO.Farletuzumab :6180-61-6Molecular Weight : Molecular formula: C9H12O2Smiles: OCCCOC1=CC=CC=C1Description: Bezuclastinib PMID:24275718 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and…
Product Name : Phosphorus, Oil based standard solution, Specpure™ P 1000μg/gSynonym: IUPAC Name : CAS NO.SB-216 :Molecular Weight : Molecular formula: Smiles: Description: Digitonin PMID:24458656 MedChemExpress (MCE) offers a wide…
Product Name : 2,6-Difluorophenol, 98%Synonym: IUPAC Name : 2,6-difluorophenolCAS NO.:28177-48-2Molecular Weight : Molecular formula: C6H4F2OSmiles: OC1=C(F)C=CC=C1FDescription: Biotin-d2-1 Terizidone PMID:24834360 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and…
Product Name : 4,6-Dichloropyrimidine, 97%Synonym: IUPAC Name : 4,6-dichloropyrimidineCAS NO.:1193-21-1Molecular Weight : Molecular formula: C4H2Cl2N2Smiles: ClC1=CC(Cl)=NC=N1Description: Vismodegib TIC10 PMID:23554582
Product Name : 4,6-Dimethyl-2-nitroaniline, 97%Synonym: IUPAC Name : 2,4-dimethyl-6-nitroanilineCAS NO.Catechin :1635-84-3Molecular Weight : Molecular formula: C8H10N2O2Smiles: CC1=CC(C)=C(N)C(=C1)()=ODescription: Vitamin D3 PMID:24282960
Product Name : 6-Nitrocoumarin, 98+%Synonym: IUPAC Name : 6-nitro-2H-chromen-2-oneCAS NO.:2725-81-7Molecular Weight : Molecular formula: C9H5NO4Smiles: (=O)C1=CC=C2OC(=O)C=CC2=C1Description: Anetumab Tigecycline PMID:23907051
Product Name : DL-Isoleucine, 99%Synonym: IUPAC Name : DL-2-amino-3-methylpentanoic acidCAS NO.:443-79-8Molecular Weight : Molecular formula: C6H13NO2Smiles: CC(C)(N)C(O)=ODescription: Gadolinium chloride Tixagevimab PMID:23008002
Product Name : 1-(5-Chloro-2-pyridyl)piperazine, 99%Synonym: IUPAC Name : CAS NO.:Molecular Weight : Molecular formula: Smiles: Description: Ascorbyl palmitate Amlexanox PMID:27108903 MedChemExpress (MCE) offers a wide range of high-quality research chemicals…
Product Name : Carbon disulfide, HPLC Grade, 99.8+%Synonym: IUPAC Name : methanedithioneCAS NO.:75-15-0Molecular Weight : Molecular formula: CS2Smiles: S=C=SDescription: Carbon disulfide is used in spectrophotometry, high performance liquid chromatography and…
Product Name : Dichloronickel(II), 98%Synonym: IUPAC Name : diphenylphosphane; dichloronickelCAS NO.:14647-23-5Molecular Weight : Molecular formula: C26H24Cl2NiP2Smiles: ClCl.Sigma-2 receptor antagonist 1 C(CP(C1=CC=CC=C1)C1=CC=CC=C1)P(C1=CC=CC=C1)C1=CC=CC=C1Description: Dichloronickel(II) is a reactant involved in Kumada catalyst-transfer polycondensation,…
Product Name : 3-Amino-6-bromo-1H-indazole, 95%Synonym: IUPAC Name : 6-bromo-1H-indazol-3-amineCAS NO.:404827-77-6Molecular Weight : Molecular formula: C7H6BrN3Smiles: NC1=NNC2=CC(Br)=CC=C12Description: Tofacitinib S1p receptor agonist 1 PMID:23291014
Product Name : Sodium n-octadecyl sulfate, 98% (dry wt.), water
Product Name : N(alpha)-Boc-L-arginine, 98%Synonym: IUPAC Name : (2S)-2-{amino}-5-pentanoic acidCAS NO.Mirvetuximab soravtansine :13726-76-6Molecular Weight : Molecular formula: C11H22N4O4Smiles: CC(C)(C)OC(=O)N(CCCN=C(N)N)C(O)=ODescription: Sulpiride PMID:36628218
Product Name : Ammonium hexachlorostannate(IV), 98%Synonym: IUPAC Name : tin(4+) diammonium hexachlorideCAS NO.:16960-53-5Molecular Weight : Molecular formula: Cl6H8N2SnSmiles: .Salinomycin .Cholestyramine .PMID:35901518 .....Description: MedChemExpress (MCE) offers a wide range of high-quality…
Product Name : Platinum(IV) iodide, 99.95% (Metals basis), Pt 27.3% min., Premion™Synonym: IUPAC Name : platinum(4+) tetraiodideCAS NO.:7790-46-7Molecular Weight : Molecular formula: I4PtSmiles: .Tropisetron .Tazarotene .PMID:23539298 .Description: MedChemExpress (MCE) offers…
Product Name : Calcium nitrate tetrahydrate, 98%, extra pureSynonym: IUPAC Name : calcium bis(nitric acid) tetrahydrateCAS NO.:13477-34-4Molecular Weight : Molecular formula: CaH10N2O10Smiles: O.Corin O.Olaratumab O.PMID:25959043 O..O()=O.O()=ODescription:
Product Name : N-Fmoc-L-glutamic acid 1-tert-butyl ester, 98%Synonym: IUPAC Name : 5-(tert-butoxy)-4-({carbonyl}amino)-5-oxopentanoic acidCAS NO.:84793-07-7Molecular Weight : Molecular formula: C24H27NO6Smiles: CC(C)(C)OC(=O)C(CCC(O)=O)NC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C12Description: Atogepant BPC 157 PMID:35850484
Product Name : 4-Bromo-3-methylphenol, 98%Synonym: IUPAC Name : CAS NO.:14472-14-1Molecular Weight : Molecular formula: Smiles: Description: Lorundrostat SAH PMID:23710097
Product Name : Neocuproine hemihydrate, 99+%Synonym: IUPAC Name : bis(2,9-dimethyl-1,10-phenanthroline) hydrateCAS NO.:34302-69-7Molecular Weight : Molecular formula: C28H26N4OSmiles: O.Auranofin CC1=CC=C2C=CC3=CC=C(C)N=C3C2=N1.Nipocalimab CC1=CC=C2C=CC3=CC=C(C)N=C3C2=N1Description: PMID:35901518 MedChemExpress (MCE) offers a wide range of high-quality research…
Product Name : Dicyclohexano-18-crown-6, mixture of isomers, 97%Synonym: IUPAC Name : 2,5,8,15,18,21-hexaoxatricyclohexacosaneCAS NO.:16069-36-6Molecular Weight : Molecular formula: C20H36O6Smiles: C1CCC2OCCOCCOC3CCCCC3OCCOCCOC2C1Description: Dicyclohexano is used as an anion activator and complexing agent which…
Product Name : Dibenzothiophene, 98%Synonym: IUPAC Name : 8-thiatricyclotrideca-1(9),2(7),3,5,10,12-hexaeneCAS NO.:132-65-0Molecular Weight : Molecular formula: C12H8SSmiles: S1C2=C(C=CC=C2)C2=C1C=CC=C2Description: Dibenzothiophene is used to investigate the effect of sulfur compounds in gasoline range during…
Product Name : cis-4-Hydroxy-L-proline, 99%Synonym: IUPAC Name : CAS NO.:618-27-9Molecular Weight : Molecular formula: Smiles: Description: cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used…
Product Name : Sulfur in Heavy Mineral Oil standard solution, Specpure™, 20μg/g (0.0020%)Synonym: IUPAC Name : CAS NO.Opipramol :Molecular Weight : Molecular formula: Smiles: Description: Anle138b PMID:23776646
Product Name : 4-n-Octylbenzoic acid, 99%Synonym: IUPAC Name : 4-octylbenzoic acidCAS NO.:3575-31-3Molecular Weight : Molecular formula: C15H22O2Smiles: CCCCCCCCC1=CC=C(C=C1)C(O)=ODescription: 4-n-Octylbenzoic acid is used as a pharmaceutical intermediate.Hydrocortisone Fezolinetant PMID:25955218
Product Name : Pentafluorobenzaldehyde, 98%Synonym: IUPAC Name : 2,3,4,5,6-pentafluorobenzaldehydeCAS NO.Perfluorohexyloctane :653-37-2Molecular Weight : Molecular formula: C7HF5OSmiles: FC1=C(F)C(F)=C(C=O)C(F)=C1FDescription: Ceftriaxone PMID:24238415
Product Name : L-Bornyl acetate, 95%Synonym: IUPAC Name : CAS NO.:5655-61-8Molecular Weight : Molecular formula: Smiles: Description: Asundexian Modakafusp alfa PMID:23800738 MedChemExpress (MCE) offers a wide range of high-quality research…
Product Name : Molybdenum hexacarbonyl, 98%Synonym: IUPAC Name : hexakis(methanidylidyneoxidanium) molybdenumCAS NO.Nelonemdaz :13939-06-5Molecular Weight : Molecular formula: C6MoO6Smiles: .Maropitant #.PMID:23775868 #.#.#.#.#Description: MedChemExpress (MCE) offers a wide range of high-quality research…
Product Name : Methacrylamide, 98%, extra pureSynonym: IUPAC Name : 2-methylprop-2-enamideCAS NO.:79-39-0Molecular Weight : Molecular formula: C4H7NOSmiles: CC(=C)C(N)=ODescription: Olutasidenib Calcein PMID:24078122 MedChemExpress (MCE) offers a wide range of high-quality research…
Product Name : 4-Boc-1-(5-bromo-2-pyridyl)piperazine, 97%Synonym: IUPAC Name : CAS NO.:Molecular Weight : Molecular formula: Smiles: Description: 4-Boc-1-(5-bromo-2-pyridyl)piperazine is used as active pharmaceutical ingredient.Phosphatidylserine Isatuximab PMID:35670838
Product Name : Palladium, 99.9%, (trace metal basis), spongeSynonym: IUPAC Name : palladiumCAS NO.:7440-05-3Molecular Weight : Molecular formula: PdSmiles: Description: Varenicline Tideglusib PMID:23659187
Product Name : trans-2-Octene, 97%Synonym: IUPAC Name : (2E)-oct-2-eneCAS NO.Romidepsin :13389-42-9Molecular Weight : Molecular formula: C8H16Smiles: CCCCC\C=C\CDescription: Pelabresib PMID:23074147
Product Name : 1-Chloro-2,4-difluorobenzene, 98%Synonym: IUPAC Name : 1-chloro-2,4-difluorobenzeneCAS NO.AEE788 :1435-44-5Molecular Weight : Molecular formula: C6H3ClF2Smiles: FC1=CC=C(Cl)C(F)=C1Description: Pelabresib PMID:24120168 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and…
Product Name : Platinum standard form crucible, Top OD 29mm, Bot Dia 17.5mm, Ht 24mm, Base Thickness 0.Milvexian 25mm, Capacity 10mLSynonym: IUPAC Name : CAS NO.Desmosterol :Molecular Weight : Molecular…
Product Name : Phenethyl isocyanate, 99%Synonym: IUPAC Name : (2-isocyanatoethyl)benzeneCAS NO.:1943-82-4Molecular Weight : Molecular formula: C9H9NOSmiles: O=C=NCCC1=CC=CC=C1Description: Vitamin D2 RGX-202 PMID:24324376
Product Name : Potassium thioacetate, 98%Synonym: IUPAC Name : ethanethioic S-acid potassiumCAS NO.Miconazole nitrate :10387-40-3Molecular Weight : Molecular formula: C2H4KOSSmiles: .Infliximab CC(S)=ODescription: PMID:28630660
Product Name : 3-Ethylbenzothiazolium bromide, 98%Synonym: IUPAC Name : 3-ethyl-1,3-benzothiazol-3-ium bromideCAS NO.:32446-47-2Molecular Weight : Molecular formula: C9H10BrNSSmiles: .Abrocitinib CC1=CSC2=CC=CC=C12Description: S2116 PMID:24293312
Product Name : 2-Fluoro-5-nitrobenzoic acid, 98%Synonym: IUPAC Name : CAS NO.:7304-32-7Molecular Weight : Molecular formula: Smiles: Description: 2-Fluoro-5-nitrobenzoic acid may be used in the synthesis of dibenzoxazepin-11(10H)-ones, via the nucleophilic…
Product Name : Thiophene-2-sulfonyl chloride, 97%Synonym: IUPAC Name : thiophene-2-sulfonyl chlorideCAS NO.:16629-19-9Molecular Weight : Molecular formula: C4H3ClO2S2Smiles: ClS(=O)(=O)C1=CC=CS1Description: 2-Thiophenesulfonyl chloride has been used in the preparation of 2-((trans-2-phenyl cyclopropyl)sulfonyl)thiopheneBardoxolone Honokiol…
Product Name : (2-Hydroxypropyl)-beta-cyclodextrin, MW ca 1250-1480Synonym: IUPAC Name : CAS NO.:128446-35-5Molecular Weight : 1180.05Molecular formula: C44H75O36Smiles: OCC-*.12O(CO)(O3()O(CO)(O4()O(CO)(O5()O(CO)(O6()O(CO)(O7()O(CO)(O8()O(CO)(O1)(O)8O)(O)7O)(O)6O)(O)5O)(O)4O)(O)3O)(O)2ODescription: 2-Hydroxypropyl)-β-cyclodextrin is used to enhance solubility of hydrophobic compounds by forming complex…
Product Name : 3-Noradamantanecarboxylic acid, 98%Synonym: IUPAC Name : (1R,5S)-tricyclononane-3-carboxylateCAS NO.Certolizumab pegol :16200-53-6Molecular Weight : Molecular formula: C10H13O2Smiles: C(=O)C12C3CC1C(C2)C3Description: Bovine Serum Albumin PMID:24324376
Product Name : 3-Nitrobenzoic Acid, 98%Synonym: IUPAC Name : 3-nitrobenzoic acidCAS NO.:121-92-6Molecular Weight : Molecular formula: C7H5NO4Smiles: OC(=O)C1=CC=CC(=C1)()=ODescription: Remdesivir Gemcitabine PMID:23773119
Product Name : Palladium, 10% on carbon, Type 487, drySynonym: IUPAC Name : palladiumCAS NO.Desmosterol :7440-05-3Molecular Weight : Molecular formula: PdSmiles: Description: It is a catalyst used in Stille reaction,…
Product Name : Spectroflux 1010A, Lithium tetraborate & Lithium metaborate, 50:50 w/w%, fusedSynonym: IUPAC Name : CAS NO.:Molecular Weight : Molecular formula: Smiles: Description: Lurasidone Hydrochloride Nystatin PMID:24257686
Product Name : Potassium selenocyanate, 99%Synonym: IUPAC Name : potassium cyanoselanideCAS NO.FMK :3425-46-5Molecular Weight : Molecular formula: CKNSeSmiles: .DPH C#NDescription: PMID:23789847 MedChemExpress (MCE) offers a wide range of high-quality research…
Product Name : 4-Chlorophenoxyacetic acid, 98%Synonym: IUPAC Name : 2-(4-chlorophenoxy)acetic acidCAS NO.Neuraminidase :122-88-3Molecular Weight : Molecular formula: C8H7ClO3Smiles: OC(=O)COC1=CC=C(Cl)C=C1Description: Emodepside PMID:23903683 MedChemExpress (MCE) offers a wide range of high-quality research…
Product Name : 1-Ethyl-3-methylimidazolium iodide, 97%Synonym: IUPAC Name : CAS NO.:35935-34-3Molecular Weight : Molecular formula: Smiles: Description: It is used as OLED materials.Atropine Sacituzumab PMID:27641997 MedChemExpress (MCE) offers a wide…
Product Name : 1,1,4,7,7-Pentamethyldiethylenetriamine, 98%Synonym: IUPAC Name : (2-{(methyl)amino}ethyl)dimethylamineCAS NO.:3030-47-5Molecular Weight : Molecular formula: C9H23N3Smiles: CN(C)CCN(C)CCN(C)CDescription: Used as ligand in NMR study of complexation/aggregation with neopentyllithium1 and in the study…
Product Name : Ethyl (methylthio)acetate, 98%Synonym: IUPAC Name : ethyl 2-(methylsulfanyl)acetateCAS NO.Kanamycins (sulfate) :4455-13-4Molecular Weight : Molecular formula: C5H10O2SSmiles: CCOC(=O)CSCDescription: Ethyl (methylthio)acetate is used as an internal standard during the…
Product Name : Potassium diphosphate, 98%, extra pureSynonym: IUPAC Name : CAS NO.:7320-34-5Molecular Weight : Molecular formula: Smiles: Description: LCS-1 Tolvaptan PMID:30125989
Product Name : Platinum Combustion Boat with handle, length 110mm, width 13mm, Ht 10mm, Capacity 12mLSynonym: IUPAC Name : CAS NO.Trimethoprim :Molecular Weight : Molecular formula: Smiles: Description: Apitegromab PMID:24580853…
Product Name : Triphenylborane, 96%Synonym: IUPAC Name : triphenylboraneCAS NO.:960-71-4Molecular Weight : Molecular formula: C18H15BSmiles: C1=CC=C(C=C1)B(C1=CC=CC=C1)C1=CC=CC=C1Description: Triphenylborane is used as a precursor in the production of pyridine-triphenylborane complex, which is…
Product Name : 1-(4-Fluorophenyl)-1-methylethylamine, 97%Synonym: IUPAC Name : CAS NO.:17797-10-3Molecular Weight : Molecular formula: Smiles: Description: Pafolacianine Ambrisentan PMID:26446225 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and…
Product Name : 3-propionic acid, 96%Synonym: IUPAC Name : 3-propanoic acidCAS NO.Salmeterol :57668-34-5Molecular Weight : Molecular formula: C16H16O3Smiles: OC(=O)CCC1=CC(OCC2=CC=CC=C2)=CC=C1Description: Psoralen PMID:24189672
Product Name : CefmetazoleSynonym: IUPAC Name : CAS NO.:Molecular Weight : Molecular formula: Smiles: Description: A broad spectrum second generation cephalosporin antibioticβ-Amyloid (1-40) (TFA) Telaprevir PMID:24140575
Product Name : Cadmium shot, 1-3mm (0.04-0.1in), Puratronic™, 99.9997% (metals basis)Synonym: IUPAC Name : cadmiumCAS NO.Secukinumab :7440-43-9Molecular Weight : Molecular formula: CdSmiles: Description: Metolazone PMID:23865629
Product Name : Tetramethylammonium formate, 30% w/w aq. soln.Synonym: IUPAC Name : CAS NO.:59138-84-0Molecular Weight : Molecular formula: Smiles: Description: Tetramethylammonium formate may provide the lowest temperature sensitivity, additionally reducing…
Product Name : Potassium hexachlororhodate(III), Premion™, 99.99% (metals basis), Rh 23.3% minSynonym: IUPAC Name : tripotassium hexachlororhodiumheptakis(ylium)CAS NO.Ibezapolstat :13845-07-3Molecular Weight : Molecular formula: Cl6K3RhSmiles: .Didox .PMID:24101108 .Cl(Cl)(Cl)(Cl)(Cl)ClDescription: Potassium hexachlororhodate(III) is…
Product Name : Pulegone, 92%, pract.Synonym: IUPAC Name : (5R)-5-methyl-2-(propan-2-ylidene)cyclohexan-1-oneCAS NO.:89-82-7Molecular Weight : Molecular formula: C10H16OSmiles: C1CCC(=C(C)C)C(=O)C1Description: Ramipril Casirivimab PMID:23996047 MedChemExpress (MCE) offers a wide range of high-quality research chemicals…
Product Name : 3-Amino-5-bromo-1-methyl-1H-indazole, 97%Synonym: IUPAC Name : 5-bromo-1-methyl-1H-indazol-3-amineCAS NO.Capsaicin :1000018-06-3Molecular Weight : Molecular formula: C8H8BrN3Smiles: CN1N=C(N)C2=CC(Br)=CC=C12Description: Opipramol PMID:24733396
Product Name : Methyl 2-chloroacetoacetate, 95%Synonym: IUPAC Name : methyl 2-chloro-3-oxobutanoateCAS NO.:4755-81-1Molecular Weight : Molecular formula: C5H7ClO3Smiles: COC(=O)C(Cl)C(C)=ODescription: Clobetasol propionate Crizotinib PMID:23341580
Product Name : Platinum Lid for Standard form crucible, Dia 37.5mm, fits Stock #s 46813 & 46580Synonym: IUPAC Name : CAS NO.:Molecular Weight : Molecular formula: Smiles: Description: Elotuzumab Acacetin…
Product Name : Copper(II) phthalocyanineSynonym: IUPAC Name : 9,18,27,36,37,39,40,41-octaaza-38-cupradecacyclohentetraconta-1,3,5,7,9,11,13,15,17(41),18,20,22,24,26,28(40),29,31,33,35-nonadecaeneCAS NO.:147-14-8Molecular Weight : Molecular formula: C32H16CuN8Smiles: 1N2C3=NC4=NC(=NC5=C6C=CC=CC6=C(N=C6N=C(N=C2C2=CC=CC=C32)C2=CC=CC=C62)N15)C1=CC=CC=C41Description: Copper(II) phthalocyanine are involved in the study of photosensitizer chemistry for uniform polymerization, luminescence…
Product Name : 2-Bromo-6-iodopyridine, 97%Synonym: IUPAC Name : CAS NO.Delgocitinib :234111-08-1Molecular Weight : Molecular formula: Smiles: Description: 6-trifluoromethyl-2-pyridinecarboxylic acid (4; 87%) was obtained from 2-bromo-6-(trifluoromethyl)pyridine, which was in turn derived…
Product Name : Bismuth vanadium oxide, 99.9% (metals basis)Synonym: IUPAC Name : bismuth(3+) vanadium tetraoxidandiideCAS NO.:14059-33-7Molecular Weight : Molecular formula: BiO4VSmiles: .D-Glucose .NMDA .PMID:35227773 ..Description: Bismuth vanadium oxide is used…
Product Name : n-Heptane, 99+%, Extra Dry over Molecular Sieve, AcroSeal™Synonym: IUPAC Name : heptaneCAS NO.:142-82-5Molecular Weight : Molecular formula: C7H16Smiles: CCCCCCCDescription: GLP-1 receptor agonist 2 Pristinamycin PMID:24189672
Product Name : (S)-(+)-4-Methyl-2-pentanol, 99%Synonym: IUPAC Name : 4-methylpentan-2-olCAS NO.:14898-80-7Molecular Weight : Molecular formula: C6H14OSmiles: CC(C)CC(C)ODescription: It is employed in the reaction of 2-methoxyethyl acetals with allylsilanes in the presence…
Product Name : Glycolic acid 70% in waterSynonym: IUPAC Name : 2-hydroxyacetic acidCAS NO.:79-14-1Molecular Weight : Molecular formula: C2H4O3Smiles: OCC(O)=ODescription: Diclofenac CNTF Protein, Mouse PMID:24101108
Product Name : Graphite rod, 3.05mm (0.12in) dia x 305mm (12in) long, 99.9995% (metals basis)Synonym: IUPAC Name : CAS NO.:Molecular Weight : Molecular formula: Smiles: Description: Graphite rod is used…
Product Name : Non-wetting Pt 5% Au crucible with RF rim, Top Dia 44mm, BotDia 26.5mm, Ht 49mm, Base Thickness 0.38mm, Capacity 50mLSynonym: IUPAC Name : CAS NO.PU-WS13 :Molecular Weight…
Product Name : Aluminum slug, 3.175mm (0.125in) dia x 3.175mm (0.125in) length, Puratronic™, 99.9999% (metals basis)Synonym: IUPAC Name : aluminiumCAS NO.:7429-90-5Molecular Weight : Molecular formula: AlSmiles: Description: Proteinase K 25-Hydroxycholesterol…
Product Name : 3,4-Methylenedioxyphenylboronic acid, 98%Synonym: IUPAC Name : (2H-1,3-benzodioxol-5-yl)boronic acidCAS NO.:94839-07-3Molecular Weight : Molecular formula: C7H7BO4Smiles: OB(O)C1=CC=C2OCOC2=C1Description: Exendin-4 Sunvozertinib PMID:24078122
Product Name : N-Acetyl-trans-4-hydroxy-L-proline, 98%Synonym: IUPAC Name : (2S,4S)-1-acetyl-4-hydroxypyrrolidine-2-carboxylateCAS NO.α-Hemolysin (Staphylococcus aureus) :33996-33-7Molecular Weight : Molecular formula: C7H10NO4Smiles: CC(=O)N1C(O)C1C()=ODescription: Fengycin PMID:23892746
Product Name : 4-Nitrophthalic anhydride, tech. 90%Synonym: IUPAC Name : 5-nitro-1,3-dihydro-2-benzofuran-1,3-dioneCAS NO.:5466-84-2Molecular Weight : Molecular formula: C8H3NO5Smiles: (=O)C1=CC=C2C(=O)OC(=O)C2=C1Description: 4-Nitrophthalic anhydride is used an an intermediate for the synthesis of a…
Product Name : 2-n-Pentylfuran, 98%Synonym: IUPAC Name : 2-pentylfuranCAS NO.:3777-69-3Molecular Weight : Molecular formula: C9H14OSmiles: CCCCCC1=CC=CO1Description: Ixabepilone Momelotinib PMID:32180353
Product Name : Glycinamide hydrochloride, 98%Synonym: IUPAC Name : hydrogen 2-aminoacetamide chlorideCAS NO.:1668-10-6Molecular Weight : Molecular formula: C2H7ClN2OSmiles: ..NCC(N)=ODescription: Glycinamide hydrochloride is a buffer that is useful in the physiological…
Product Name : trans-1,4-Diaminocyclohexane, 99%Synonym: IUPAC Name : cyclohexane-1,4-diamineCAS NO.:2615-25-0Molecular Weight : Molecular formula: C6H14N2Smiles: NC1CCC(N)CC1Description: Biperiden Voclosporin PMID:23341580
Product Name : 6-Bromopyridine-2-carboxaldehyde, 97%Synonym: IUPAC Name : 6-bromopyridine-2-carbaldehydeCAS NO.:34160-40-2Molecular Weight : Molecular formula: C6H4BrNOSmiles: BrC1=CC=CC(C=O)=N1Description: 6-Bromopyridine-2-carboxaldehyde is used in the study of a rhodium-catalyzed, reductive aldol coupling with divinyl…
Product Name : Copper wire, 0.5mm (0.02 in.) dia., Puratronic™, 99.999% (metals basis)Synonym: IUPAC Name : copperCAS NO.:7440-50-8Molecular Weight : Molecular formula: CuSmiles: Description: Bempedoic acid Coelenterazine PMID:23563799
Product Name : 2,2-Difluorosuccinic acid, 94%Synonym: IUPAC Name : 2,2-difluorobutanedioic acidCAS NO.:665-31-6Molecular Weight : Molecular formula: C4H4F2O4Smiles: OC(=O)CC(F)(F)C(O)=ODescription: 2,2-Difluorosuccinic acid is used in the preparation of fluorofumaric acid.Golidocitinib It is…
Product Name : Sodium hydrogen phosphate, anhydrous, ACS, 99.0% minSynonym: IUPAC Name : disodium hydrogen phosphateCAS NO.:7558-79-4Molecular Weight : Molecular formula: HNa2O4PSmiles: ..OP()()=ODescription: Sodium hydrogen phosphate is used in food…
Product Name : 3-Cyanopyridine-4-boronic acid pinacol ester, 95%Synonym: IUPAC Name : 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrileCAS NO.Entacapone :878194-92-4Molecular Weight : Molecular formula: C12H15BN2O2Smiles: CC1(C)OB(OC1(C)C)C1=C(C=NC=C1)C#NDescription: Lysostaphin PMID:36717102
Product Name : Cobalt(IV) sulfide, 99.5% (metals basis)Synonym: IUPAC Name : disulfanylidenecobaltCAS NO.:12013-10-4Molecular Weight : Molecular formula: CoS2Smiles: S==SDescription: Cobalt(IV) sulfide is a promising battery electrode material exhibiting good electrochemical…
Product Name : 2-Bromo-3,3,3-trifluoro-1-propene, 97%Synonym: IUPAC Name : CAS NO.:1514-82-5Molecular Weight : Molecular formula: Smiles: Description: It is used as intermediate in production of organ fluorine compounds & as a…
Product Name : 3-(Trifluoromethyl)aniline, 99%Synonym: IUPAC Name : 3-(trifluoromethyl)anilineCAS NO.:98-16-8Molecular Weight : Molecular formula: C7H6F3NSmiles: NC1=CC=CC(=C1)C(F)(F)FDescription: Used as pharmaceutical intermediate.Valbenazine Neurotrophin-3 Protein, Human PMID:23910527
Product Name : Pravastatin sodium salt hydrateSynonym: IUPAC Name : sodium (3R,5R)-7-oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoateCAS NO.Xanthine oxidase :2244386-63-6Molecular Weight : Molecular formula: C23H35NaO7Smiles: .Afatinib dimaleate 12(C(O)C=C1C=C(C)2CC(O)C(O)CC()=O)OC(=O)(C)CCDescription: PMID:23907521
Product Name : Sodium thiocyanate, 96%Synonym: IUPAC Name : sodium cyanosulfanideCAS NO.:540-72-7Molecular Weight : Molecular formula: CNNaSSmiles: .C#NDescription: A compound used to convert alkyl halides into the corresponding alkylthiocyanates. Undergoes…
Product Name : Homophthalic anhydride, 98%Synonym: IUPAC Name : 3,4-dihydro-1H-2-benzopyran-1,3-dioneCAS NO.:703-59-3Molecular Weight : Molecular formula: C9H6O3Smiles: O=C1CC2=CC=CC=C2C(=O)O1Description: LCS-1 Golidocitinib PMID:24578169
Product Name : 2-Methoxyethyl acrylate, 98%, stab. with ca 50-100ppm 4-methoxyphenolSynonym: IUPAC Name : CAS NO.Mometasone furoate :3121-61-7Molecular Weight : Molecular formula: Smiles: Description: Aprepitant-d4 PMID:24179643
Product Name : Sodium hydroxide, 1.0 N in aqueous solution, WFI, Biotech Reagent, GMP, J.T.Baker™Synonym: Sodium hydrate, Soda lye, Caustic soda, LyeIUPAC Name : CAS NO.:1310-73-2Molecular Weight : 40Molecular formula:…
Product Name : n-Butyl acetate, HPLC Grade, 99.5+%Synonym: IUPAC Name : butyl acetateCAS NO.:123-86-4Molecular Weight : Molecular formula: C6H12O2Smiles: CCCCOC(C)=ODescription: n-Butyl acetate is used as a mobile phase in High…
Product Name : Eflornithine hydrochloride monohydrateSynonym: IUPAC Name : hydrogen 2,5-diamino-2-(difluoromethyl)pentanoic acid hydrate chlorideCAS NO.:96020-91-6Molecular Weight : Molecular formula: C6H15ClF2N2O3Smiles: .Osimertinib mesylate O.Calcitonin (salmon) .PMID:25023702 NCCCC(N)(C(F)F)C(O)=ODescription:
Product Name : Thiourea, 99%, extra pureSynonym: IUPAC Name : thioureaCAS NO.:62-56-6Molecular Weight : Molecular formula: CH4N2SSmiles: NC(N)=SDescription: Ingenol Neratinib PMID:23891445
Product Name : Perfluoro-1-butanesulfonyl fluoride, 92%Synonym: IUPAC Name : nonafluorobutane-1-sulfonyl fluorideCAS NO.:375-72-4Molecular Weight : Molecular formula: C4F10O2SSmiles: FC(F)(F)C(F)(F)C(F)(F)C(F)(F)S(F)(=O)=ODescription: Miridesap Iberdomide PMID:23991096
Product Name : NitenpyramSynonym: IUPAC Name : (ethyl)amino}-2-nitroethenyl](methyl)amineCAS NO.Hydrochlorothiazide :150824-47-8Molecular Weight : Molecular formula: C11H15ClN4O2Smiles: CCN(CC1=CC=C(Cl)N=C1)C(\NC)=C\()=ODescription: Osimertinib PMID:34337881
Product Name : Bromoform, 96%, stab. with ethanolSynonym: IUPAC Name : tribromomethaneCAS NO.Flecainide acetate :75-25-2Molecular Weight : Molecular formula: CHBr3Smiles: BrC(Br)BrDescription: Bromoform is widely used as a solvent for waxes,…
Product Name : o-Tolyl isothiocyanate, 98%Synonym: IUPAC Name : 1-isothiocyanato-2-methylbenzeneCAS NO.Tixagevimab :614-69-7Molecular Weight : Molecular formula: C8H7NSSmiles: CC1=CC=CC=C1N=C=SDescription: Silibinin PMID:23543429
Product Name : Thiamine nitrateSynonym: IUPAC Name : 3--5-(2-hydroxyethyl)-4-methyl-3H-1λ⁴,3-thiazol-1-ylium nitrateCAS NO.Cemiplimab :532-43-4Molecular Weight : Molecular formula: C12H17N5O4SSmiles: ()=O.Hydroxychloroquine sulfate CC1=C(CCO)=CN1CC1=CN=C(C)N=C1NDescription: PMID:23935843
Product Name : Tetrapropylammonium perruthenateSynonym: IUPAC Name : tetrapropylazanium tetrahydrate rutheniumCAS NO.:114615-82-6Molecular Weight : Molecular formula: C12H36NO4RuSmiles: O.Abatacept O.Valganciclovir hydrochloride O.PMID:23715856 O..CCC(CCC)(CCC)CCCDescription:
Product Name : 4-Amino-1-(2-pyridyl)piperidine hydrochloride, 97%Synonym: IUPAC Name : CAS NO.:Molecular Weight : Molecular formula: Smiles: Description: 4-Amino-1-(2-pyridyl)piperidine hydrochloride is used as pharmaceutical intermediate.Diclofenac potassium Protirelin PMID:23557924
Product Name : (R)-(-)-2-Aminononane, ChiPros 99+%, ee 98+%Synonym: IUPAC Name : CAS NO.:74069-74-2Molecular Weight : Molecular formula: Smiles: Description: Protirelin Tricin PMID:24377291
Product Name : Magnesium ribbon, approximate dimensions, 3.0mm (0.12in) wide, 0.15mm (0.0059in) thickSynonym: IUPAC Name : magnesiumCAS NO.Atogepant :7439-95-4Molecular Weight : Molecular formula: MgSmiles: Description: Lornoxicam PMID:23329319
Product Name : 1-Heptanol, 98%Synonym: IUPAC Name : heptan-1-olCAS NO.:111-70-6Molecular Weight : Molecular formula: C7H16OSmiles: CCCCCCCODescription: Tebuconazole Pembrolizumab PMID:24513027
Product Name : 1-Ethoxy-2-propanol, 90+%, remainder 2-ethoxy-1-propanolSynonym: IUPAC Name : 1-ethoxypropan-2-olCAS NO.:1569-02-4Molecular Weight : Molecular formula: C5H12O2Smiles: CCOCC(C)ODescription: 1-Ethoxy-2-propanol is used as a solvent for a wide variety of resins…
Product Name : Terbium(III) trifluoromethanesulfonate, 98%Synonym: IUPAC Name : terbium(3+) tritrifluoromethanesulfonateCAS NO.:148980-31-8Molecular Weight : Molecular formula: C3F9O9S3TbSmiles: .S(=O)(=O)C(F)(F)F.S(=O)(=O)C(F)(F)F.S(=O)(=O)C(F)(F)FDescription: It is used as a reagent & chemical intermediates.Tebuconazole It is a…
Product Name : Tungsten slug, 3.175mm (0.125in) dia x 3.175mm (0.125in) length, 99.97% (metals basis)Synonym: IUPAC Name : tungstenCAS NO.Alpidem :7440-33-7Molecular Weight : Molecular formula: WSmiles: Description: Sertindole PMID:25818744
Product Name : 5-Amino-3-tert-butyl-1-methylpyrazole, 98%Synonym: IUPAC Name : CAS NO.Pindolol :118430-73-2Molecular Weight : Molecular formula: Smiles: Description: Lixisenatide PMID:35567400
Product Name : m-Cresol, 99%Synonym: IUPAC Name : 3-methylphenolCAS NO.:108-39-4Molecular Weight : Molecular formula: C7H8OSmiles: CC1=CC=CC(O)=C1Description: TMRE Methimazole PMID:24078122
Product Name : Phosphotungstic acid hydrateSynonym: IUPAC Name : 12-Tungstophosphate hydrateCAS NO.Inclisiran :12501-23-4Molecular Weight : 2880.Verteporfin 20Molecular formula: Smiles: Description: PMID:24211511
Product Name : 1-Chloro-4-ethynylbenzene, 98%Synonym: IUPAC Name : 1-chloro-4-ethynylbenzeneCAS NO.Brazikumab :873-73-4Molecular Weight : Molecular formula: C8H5ClSmiles: ClC1=CC=C(C=C1)C#CDescription: 15-Deoxy-Δ-12,14-prostaglandin J2 PMID:23962101
Product Name : Methyl indole-3-carboxylate, 99%Synonym: IUPAC Name : methyl 1H-indole-3-carboxylateCAS NO.:942-24-5Molecular Weight : Molecular formula: C10H9NO2Smiles: COC(=O)C1=CNC2=CC=CC=C12Description: Reactant used for preparation of nitric oxide synthesis (nNOS) inhibitors, protein kinase…
Product Name : 4-Hydroxy-3-methoxymandelic acid, 99%Synonym: IUPAC Name : (2S)-2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)acetateCAS NO.:55-10-7Molecular Weight : Molecular formula: C9H9O5Smiles: COC1=CC(=CC=C1O)(O)C()=ODescription: Doxycycline monohydrate Nipocalimab PMID:24914310
Product Name : Gold, AAS standard solution, Specpure™ Au 1000μg/mLSynonym: IUPAC Name : CAS NO.:Molecular Weight : Molecular formula: Smiles: Description: Gold, AAS standard solution is used for the determination…
Product Name : 5-Chloroindole-2-carboxylic acid, 98%Synonym: IUPAC Name : CAS NO.Belvarafenib :Molecular Weight : Molecular formula: Smiles: Description: Potent antagonist at the glycine site of the NMDA receptorLomustine PMID:35116795
Product Name : Valeric Acid, 99%Synonym: IUPAC Name : pentanoic acidCAS NO.:109-52-4Molecular Weight : Molecular formula: C5H10O2Smiles: CCCCC(O)=ODescription: GSK1059615 Clobetasol propionate PMID:24518703
Product Name : N-Fmoc-O-tert-butyl-L-allo-threonine, 97%Synonym: IUPAC Name : (2S,3S)-3-(tert-butoxy)-2-({carbonyl}amino)butanoic acidCAS NO.Tebipenem :201481-37-0Molecular Weight : Molecular formula: C23H27NO5Smiles: C(OC(C)(C)C)(NC(=O)OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)C(O)=ODescription: L-Glutamine PMID:23907051
Product Name : 5-Sulfoisophthalic acid monosodium salt, 95%Synonym: IUPAC Name : sodium 3,5-dicarboxybenzene-1-sulfonateCAS NO.:6362-79-4Molecular Weight : Molecular formula: C8H5NaO7SSmiles: .Vobramitamab OC(=O)C1=CC(=CC(=C1)C(O)=O)S()(=O)=ODescription: It can be used as the third monomer in…
Product Name : cis-2-Amino-1-cyclohexanecarboxamide, 98+%Synonym: IUPAC Name : (1S,2R)-2-carbamoylcyclohexan-1-aminiumCAS NO.Gemifloxacin mesylate :115014-77-2Molecular Weight : Molecular formula: C7H15N2OSmiles: NC(=O)1CCCC1Description: Trastuzumab emtansine PMID:24563649
Product Name : 3-Amino-4-methoxybenzamide, 98%Synonym: IUPAC Name : 3-amino-4-methoxybenzamideCAS NO.:17481-27-5Molecular Weight : Molecular formula: C8H10N2O2Smiles: COC1=CC=C(C=C1N)C(N)=ODescription: Nebivolol hydrochloride Baclofen PMID:23291014
Product Name : Trimethylacetylacetonitrile, 99%Synonym: IUPAC Name : 4,4-dimethyl-3-oxopentanenitrileCAS NO.:59997-51-2Molecular Weight : Molecular formula: C7H11NOSmiles: CC(C)(C)C(=O)CC#NDescription: Trimethylacetylacetonitrile is a useful intermediate.AEE788 4,4-Dimethyl-3-oxopentanenitrile has been used in the preparation of 4,4-dimethyl-3-oxo-2-benzylpentanenitrile,…
Product Name : Platinum wire, 0.1mm (0.004in) dia, Premion™, 99.997% (metals basis)Synonym: IUPAC Name : platinumCAS NO.:7440-06-4Molecular Weight : Molecular formula: PtSmiles: Description: Rucaparib Camsylate Netarsudil (hydrochloride) PMID:24065671
Product Name : 5-Bromoimidazopyridine, 97%Synonym: IUPAC Name : 5-bromoimidazopyridineCAS NO.VAL-083 :69214-09-1Molecular Weight : Molecular formula: C7H5BrN2Smiles: BrC1=CC=CC2=NC=CN12Description: Indacaterol PMID:24580853
Product Name : 2-Bromo-5-hydroxypyridine, 95%Synonym: IUPAC Name : 6-boranylpyridin-3-olCAS NO.:55717-45-8Molecular Weight : Molecular formula: C5H6BNOSmiles: BC1=CC=C(O)C=N1Description: It is used as an active pharmaceutical intermediate and in the coupling reactions with…
Product Name : D-(+)-Glucono-1,5-lactone, 99%Synonym: IUPAC Name : CAS NO.:90-80-2Molecular Weight : Molecular formula: Smiles: Description: Glucono delta-lactone (GDL) is a kind of excellent multifunctional food additive. It is mainly used…
Product Name : 2-Butoxyethyl acetate, 98%Synonym: IUPAC Name : CAS NO.Ipratropium bromide :112-07-2Molecular Weight : Molecular formula: Smiles: Description: Netarsudil (dimesylate) PMID:25558565
Product Name : Trichloroacetic acid, 99%Synonym: IUPAC Name : trichloroacetic acidCAS NO.:76-03-9Molecular Weight : Molecular formula: C2HCl3O2Smiles: OC(=O)C(Cl)(Cl)ClDescription: Protein precipitation reagent Trichloroacetic acid is used as a precipitating agent in…
Product Name : Manganese(IV) oxide, Puratronic™, 99.996% (metals basis)Synonym: IUPAC Name : dioxomanganeseCAS NO.:1313-13-9Molecular Weight : Molecular formula: MnO2Smiles: O==ODescription: It is used as an oxidizing agent in organic synthesis…
Product Name : Molecular sieves, 4A, -8+12 (ca 2mm) beadsSynonym: 2--5-methoxy-4-(methoxycarbonyl)-3-methyl-5-oxopentanoic acidIUPAC Name : Molecular sievesCAS NO.:70955-01-0Molecular Weight : Molecular formula: Smiles: Description: Molecular sieves, 4 Å is used to…
Product Name : 2-Cyclopropylethanol, 96%Synonym: IUPAC Name : CAS NO.:2566-44-1Molecular Weight : Molecular formula: Smiles: Description: 2-Cyclopropylethanol is used to prepare (2-bromo-ethyl)-cyclopropane by reacting with phosphorus tribromide.α-L-Fucosidase Anti-Mouse IFN gamma…
Product Name : 1-n-Butyl-3-methylpyridinium tetrafluoroborate, 99%Synonym: IUPAC Name : 1-butyl-3-methylpyridin-1-ium; tetrafluoroboranuideCAS NO.Encorafenib :597581-48-1Molecular Weight : Molecular formula: C10H16BF4NSmiles: F(F)(F)F.Genipin CCCC1=CC=CC(C)=C1Description: PMID:23075432
O harboring wild-type EGFR but with intrinsic resistance (A549 and H1299), two with secondary mutation T790M in EGFR (CL97 and H1975), and one particular (PC9/IR) with an acquired mutation of…
By interfering together with the ligand-dependent HER3-mediated signaling (20). T-DM1, which was authorized in February, 2013 is definitely an immunoconjugate agent combining trastuzumab with an antimicrotubule cytotoxic chemotherapeutic agent linked…
Ated IC50s, calculated by linear regression dose-effect plots, are supplied in the bottom of every single graph. (C) Assessment of induction of apoptosis shows a preferential proapoptotic impact of NVP-BGT226…
Ernoff GF: Shiverer: an autosomal recessive mutant mouse with myelin deficiency. J Hered 1981, 72:128. 64. Lam FC, Liu R, Lu P, Shapiro AB, Renoir JM, Sharom FJ, Reiner PB:…
With a positive monovalent ion placed at 3 (in the direction rOP1 + rOP2) away from each phosphate group. We removed the dangling phosphate groups at the 5 ends to…
621-5340, Fax: 82-32-621-5322, E-mail: [email protected] CC That is an open-access report distributed below the terms on the Inventive Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution,…
L neurons, though having no significant influence on action potential-independent glutamatergic transmission in those neurons . For that reason, primarily based on the current demonstration that the structural integrity with…
Ular Devices), as outlined in Knapman et al. (2013). Briefly, membrane prospective blue dye was dissolved in low potassium HEPES-buffered saline (HBS) of composition (mM): NaCl 140, CaCl2 1.3, MgCl2…
3.0 M KOH. Neat substrate was added portionwise (in 10 or 20 mM increments) more than time, and product formation was measured by GC/MS. The reaction utilizing complete cells overexpressing…
Ost (but not all) p53 cancer related mutants (Ansari et al., 2012; Scheffner et al., 1992). A second modality of E6 association with p53 was defined employing bacterially expressed E6…
Mes. The need for a multimethodological, or maybe multimodal, strategy to oligosaccharide examination will not be appealing to some investigators due to the procedural problems, but combining the most effective…
MO, USA) for 48 hours. Concentrations of 0, 1.0 or ten nmol/L were utilised to study the mechanisms of DAPT in PC12 cell apoptosis. PC12 cell viability detected by 3-(four,5-dimethylthiazol2-yl)-2,5-diphenyltetrazolium…
Organ-protective efforts, one example is in the setting of coronary artery occlusion or organ transplantation. These efforts target frequent mechanisms of ischemic tissue injury like cellular Ca2+ overload, the generation…
Previously reported U1 8412 construct (32) that consists of a partial deletion on the very first and second binding web-sites of Prp8 on U1 snRNA. U1 8412 grows slightly slower…
Fective communication and educational efforts are needed to attain heatvulnerable populations and assistance motivate productive protective behaviors. Additional study is needed to understand which risk communications strategies and programs are…
Ophobicity and shape, clearly abolishing inhibitor binding. The third E. coli resistance mutation, A189E (C110E in P. aeruginosa PheRS), is positioned directly in front with the -helix that forms an…
The some proteins which are induced to cope together with the oxidative strain. We hypothesize that several of the mechanisms described above (i.e. phosphorylation, mono-ADP ribosylation, andFree Radic Biol Med.…
Sphorylated compounds in the course of exerciseIn this study, we sought to examine the alterations in phosphorylated compounds throughout exercising following high-intensity short-term training. Although PCr kinetics were unchanged, the…
0 to 21 dpi among vehicle-treated group was 15.761.28, the cumulative clinical scores (day 01 dpi) amongst groups treated with 0.03, 0.1, and 0.3 mg/kg fingolimod had been 11.561.65, 0.8360.65,…
Al post puff inhalation volume differs from individual to individual and varies among 650 and 840 ml in line with St. Charles et al. (2009). Moreover, a typical puff concentration…
In the secretory pathway, altering their molecular weight. Thus, progressive protease maturation is a marker that can pinpoint protease location during vacuolar transit.40,82 (The reader is referred to figure 2…
Crinol 2011;9:124 7. Cemgil Arikan D, Aral M, Coskun A, Ozer A. Plasma IL-4, IL-8, IL-12, interferon-g and CRP levels in pregnant females with preeclampsia, and their relation with severity…
Duction of 1-methyl substitution around the N2 face of His97 (Fig. 1c). WT and V66A/L68V CzrAs have identical Zn(II)-bound crystal structures So that you can determine the structural origin of…
Mitotic cell cycle signal transduction GTPase activator activity positive regulation of GTPase activity phosphatidylinositol-3-phosphate binding cell communication phosphatidylinositol binding mitotic cell cycle spindle assembly checkpoint ubiquitin-protein ligase activity mitochondrial inner…
M.; Joseph, P.; Hale, B.; Beyersmann, D. Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology 2003, 192, 9517. 39. Bursch, W.; Karwan, A.; Mayer, M.; Dornetshuber, J.; Fr wein, U.;…
N domain (TM1, -2, -4, and -5) in gray and the transport domain: TM3 (light brown), TM6 (blue), TM7 (orange), TM8 (purple), HP1 (yellow), and HP2 (red). L-Aspartate is shown…
Rformance evaluation of OraQuick HCV speedy testrently out there, early diagnosis and intervention are extremely critical to stop illness progression. A uncomplicated, non-instrumented, rapid, point-of-care test, the OraQuick HCV Fast…
Grating signals from HER-family and PI3K/ mTOR signaling to regulate this biology. Consequently, we tested the role of p70S6K usingCell Signal. Author manuscript; available in PMC 2015 August 01.NIH-PA Author…
Ression from the 3 capsid proteins VP2, VP5 and VP7 from three separate rMVA following a DNA prime/MVA boost vaccination regime was required to confer protective immunity inside a BTV…
Approaches 2010, two, 31025. Fahey, J.W.; Zhang, Y.S.; Talalay, P. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that shield against chemical carcinogens. Proc. Nat. Acad. Sci. USA…
"off-rate", extra avid CD20 binding. can be given subcutaneously Enhanced binding to FCyRIIa Enhanced Fc binding; superior ADCC Diverse epitope, superior ACDD, CDC and PCDCLL/NHLVeltuzumab Ocrelizumab LY2469298 BM-caI I I…
H mid-cycle visits adjusted based on fertility monitor indication of days of peak fertility (Clearblue Straightforward Fertility Monitor, Inverness Healthcare, Waltham, MA, USA) (30). Participants synchronized the monitor to their…
Constant level of fructose had shown a minimal influence on the time taken for drug release (Figure 14(b)). (4) From Figure 14(c), the significant contribution on the fructose around the…
Ro can distinguish ERK1/2 phosphorylation in human xenograft tumors from surrounding mouse stromal cells in response to erlotinib treatment HCC827 xenograft mice have been treated with one particular dose of…
Vated levels of inflammatory markers have also been connected with depressive symptoms (10). A major mechanistic hypothesis suggests that inflammation may possibly serve as a typical pathway of disease for…
(Santa Cruz Biotechnology, Sta. Cruz, CA, USA). Then, they were incubated using a secondary antibody conjugated to horseradish peroxidase for 1 h at area temperature. Immunoreactive proteins had been visualised…
Ls of stat-1 and stat-3 signaling: An implication for the pathogenesis of arthritis. Arthritis Rheumatol. 2009, 60, 1451462. 32. Dai, X.; Sayama, K.; Tohyama, M.; Shirakata, Y.; Yang, L.; Hirakawa,…
Le with survival from initiation of chemotherapy for the 26 sufferers who at some point needed intervention (by addition of time to process and survival following process; Table 1). Moreover,…
E escaping in the polymerizing emulsion just after the pore walls had mostly gelled. The impact of catalyst concentration on pore structure was also evaluated. Void size decreased from 0.9…
Red for the production of solubilizing compounds, the N-source could handle the extent of acid production by PSB which will be critical to evaluate the suitability of PSB as successful…
DyFeature MAV MAVS RMS VAR WL Equation N X 1 MAV k N jx i jiDescription It adds the absolute worth of all the values within a segment divided by…
Se transport while in the muscle. HFD feeding of these PDGF receptor-expressing transgenic mice brought about resistance to each PDGF and insulin action on glucose transport, even though PDGF receptor…
Tolerance against these non-pathogenic antigens is essential for gut homeostasis. Loss of tolerance has been demonstrated to be crucial for the development of a range of intestinal pathologies; among these,…
And from MEF feeder cells alone were ready as described above. We discovered that the expression level of the proapoptosis protein BAX was increased in iPSCs by therapy with DEHP,…
Of Hurricanes Katrina and Rita in 2005 as denominators inside the calculations of incidence and death prices.12,13 Bridged single-race data permitted for comparability among the pre- and post-2000 racial/ ethnic…
three transport by monitoring the price of acidification of a weakly buffered external medium. They reported that, except for AQP1, expression of AQP3, AQP8, and AQP9 improved acidification, confirming their…
Monitoring/manipulating the contents of WM; the VLPFC, that appears to play a part in specification and/or upkeep of cues for long-term retrieval and encoding. Finally, it must also be noted…
Ombocytopenia G3 Thrombocytopenia GBRITISH JOURNAL OF CANCERPhase I study of sirolimus plus gemcitabine in strong tumoursAn Alliance 2695 (Milford, MA, USA) separations module and photodiode array detector, with Empower two…
Sistance markers (eg, KPC, NDM, OXA, VIM, IMP, Guiana extended-spectrum -lactamase , German imipenemase , and S Paulo metallo-lactamase carbapenemases). Currently accessible systems contain Verigene (Luminex, Austin, Texas) , BioFire…
Ion.12 The data are also consistent with prior reports that isolation-reared mice show an enhanced sensitivity to seizures induced by the GABA antagonist, picrotoxin,47 and developmental decreases in reelin-positive and…
Ells (Figure 2b). Much more especially, AKT1 and AKT3, but not AKT2, phosphorylations have been decreased in HPIP-depleted MCF7 cells, therefore demonstrating a function for HPIP in estrogen-dependent activation of…
D b3-integrins in hemostasis. Thrombin, by binding to G protein coupled, proteaseactivated receptors, is often a potent activator of integrins. Conversely, outside-in signaling via integrins amplifies events initiated by thrombin,…
Ig. 6c ), despite the fact that we've detected MSC expansion of Treg previously applying these approaches . Treg expansion could not be detected following treatment with either non-stimulated MSC…
E our data recommend that JMJD1C does not act directly as a H3K9 HDM, it nonetheless might be involved in regulating transcription and/or other cellular processes. Firstly, JMJD1C could, unexpectedly,…
Ectively measured ovulation rates. This might reflect a perceived experience of variability in the menstrual cycle with a retrospective reporting bias that seems to become comparable in both females with…
Ry vascular disease. These contain cardiomyopathies associated with fibrosis, hypertrophy, and abnormal lipid accumulation (9). How FOs strengthen cardiac function in cardiomyopathies representative of these with diabetes and obesity has…
) Ubiquitination directly enhances activity in the deubiquitinating enzyme ataxin-3. EMBO J. 28, 37282. Todi, S.V., Scaglione, K.M., Blount, J.R., Basrur, V., Conlon, K.P., Pastore, A. et al. (2010) Activity…
1 | www.plosone.organd thereby the migration of LAPC from the infected lungs towards the dLN and subsequent TFH cell accumulation. To this finish IAVinfected mice have been treated by i.p.…
Imary small cell neuroendocrine carcinoma in the breast. J Exp Clin Cancer Res 2004, 23:69196. 30. Jochems L, Tijalma WA: Principal smaller cell neuroendocrine tumor in the breast. Eur J…
Sues . Otherwise, it really is probably that GLO1 function is compromised in diabetes.Perspectives This critique summarizes current studies from the standard physiological regulation of HIF-1, the mutual connection in…
, with samples from all experimental circumstances present on all gels. Following transfer, mouse samples had been subjected to immunoblot evaluation to detect Nampt protein (Bethyl, A30072A). Workout training-induced adaptation…
2] Newham DJ, Jones DA, Ghosh G Aurora P. Muscle fatigue and pain after eccentric contractions at long and brief length. Clin Sci. 1988; 74(five): 553-7. Hough T. Ergographic research…
1 to 3 HexNAc units (Fig. 4, A and B). Manual assignment of EThcD spectra for glycopeptides with several HexNAc units revealed that every HexNAc is connected to a distinct…
Ne and inflammatory responses. One example is, early reports showed that PA could act as a lymphocyte mitogen . As a result, bidirectional communication hyperlinks the uPA/uPAR method along with…
Herefore lowering the possible of fungal dissemination. Evaluation on the expression levels of brlA, an indispensable gene in the control of conidiophore formation , indicated that brlA expression is dependent…
Bserved for the other phases in the cycle (Table S5). In addition, no substantial distinction in MMP-2 mRNA expression in epithelial and stromal cells ready from unique occasions in the…
Ve mRNA expression was calculated accordingly using the Ct method. All PCR primers had been created applying the application PRIMER3 employing published sequence data obtained from the NCBI database. three.8.…
Making use of a rotary evaporator to kind a solid thin film. Typical saline (1 mL) was added for the film at 60 and vortexed for five min. The resulting…
Tylglucosamine; green circles, mannose.21020 JOURNAL OF BIOLOGICAL CHEMISTRYVOLUME 288 Quantity 29 JULY 19,Enzymatic Trifucosylation of N-Glycansanalyzing C. elegans mutants lacking this enzyme. The fut-6 single mutant was previously shown to…
Al trials of this agent . We find the viral response for the IFN-based therapy plays a crucial role in predicting end-of-treatment response (Fig. 1). In this regard, a lead-in…
S: Metabolic syndrome, Insulin resistance, Fu Fang Zhen Zhu Tiao Zhi formula (FTZ)Background Reaven noted that dyslipidemia, hypertension and hypertriglyceridemia usually occurred together . Consequently, this author proposed the concept…
Ctors of HBV co-infection detected at any time through the study period (n=119,323; HBV co-infection prevalence of 1.7 ). Exactly the same important predictors of HBV co-infection have been identified…
Pite the small sample. A final consideration is that we studied patients with spontaneous headache attack. This is a point of great strength of our work, since confounding factors linked…
Osa Acinetobacter spp. Haemophilus spp. Moraxella catarrhalis Klebsiella spp. Escherichia coli Enterobacter spp. Proteus mirabilis Stenotrophomonas maltophilia Polymicrobial Culture negative Bacteremia 117 (58.8) 82 (41.2) 12 (6.0) 4 (2.0) 7…
We identified that autocrine TNF- secretion, with all the support of enhanced proteasome activity, contributed to a constitutive activation in the NF-B pathway in LICs. Though we observed different sensitivities…
Ature. Malaria parasite DNA was extracted making use of chelex-100 process as described previously . Genotyping for Pfcrt-K76T was performed applying PCR-RFLP solutions described by Schneider and others . All…
Blend with an rising level of ondansetron HCl. Measurement of film thickness Thickness of every film was measured working with thickness gauze (Mitutoyo, Japan). The measurement of thickness of every…
An very simple bending. Furthermore, distinct combinations of twisting can achieve exactly the same bending angle. Consequently, the induction of DNA twisting upon the HMGB1 protein binding might only be…
Bjected to immunopurification by utilizing GFP-affinity beads. Total proteins (Input) and immunopurified proteins (IP) were subjected to SDS/PAGE and blotted. Blots had been incubated with -GFP antibody to detect the…
Ng the early apoptosisMost cell culture models of oxidative pressure employ H2O2 because the pro-oxidant to induce oxidative strain since it is capable of altering the intracellular redox state of…
Andard resolution was added to 50 mg of starch, equivalent to concentrations in the variety 0.1-2 ppm (w/w), working with aluminum foil sample wraps which were prepared before evaluation and…
. Contradictory reports of CD44 involvement in progression and simultaneous loss of expression in particular cancer types, like endometrial and squamous cell cancers, illustrate the complex roles of this HSPG…
Lized with GAPDH mRNA expression. Values had been normalized to 37uC group (37uC set to 1). Benefits had been reported as means six SD from 3 independent experiments. N =…
Atients in which the benefit-risk ratio could be optimized prespecified subanalysisCardiol Ther (2013) two:57were performed. Inside the subgroup of individuals using a qualifying MI within the earlier two weeks to…
Ergetics from the system, particularly when backed up by a priori understanding of conformational sub-space. Even though the temperature dependence with the CD spectra for all three alanine based peptides…
Y employing gold nanoparticles bearing a number of TFAg moieties (TF-Au) covalently attached to the particles by way of the polyethylene glycol (PEG) linker and handle nanoparticles, on which PEG…
Tes C/EBPb activity by growing its transcription and protein levels. The Cebpb gene encodes a single transcript which is translated into 3 isoforms due to option use of unique AUG…
13 mV in LTG-treated rats). Likewise, the firing threshold of CA1 neurons weren't distinctive in slices ready from LTG-treated, kindledEpilepsia. Author manuscript; accessible in PMC 2014 July 01.Srivastava et al.Pagecontrol…
Fenib inside the first-line setting for sophisticated HCC is ongoing, with an estimated study completion date of June 2019 (NCT02576509)186. Similarly, in November 2018, the FDA granted accelerated approval to…
Uding lots of candidate divisions (Nicholson et al., 1987; Ley et al., 2006; Kunin et al., 2008b; Dillon et al., 2009). Extensive measurements have already been performed on these communities,…
Egions studied (12 brain places) may possibly not be adequate to detect regional associations. To improve the robustness of the evaluation, we used the median worth of 21 people and…
Progenitor transcription element Crx compared with control cultures induced with 0 nM Pur and 10 nM RA. The symbol * denotes significance more than 10, 100, 250, and 500 nM…
(n=119) and 16.34 of examined buffaloes (n= 104) had L. serrata nymphs in mesenteric lymph nodes with ranging from 1 to 16. Since of close contact in between dogs and…
Ine models of autoimmune disease such as Experimental Autoimmune Encephalomyelitis , Sort I Diabetes , collagen-induced arthritis , Uveitis , Sjogren's Syndrome , Colitis and graft vs host illness .…
two on water bath. Supernatants were separated by centrifugation, whilst the residue was washed by manual shaking with 5 ml ultrapure water for 1 min. Extracts and rinse had been…
S thaliana. Silence 2012, three:6. 22. Kim YJ, et al: The part of Mediator in tiny and lengthy noncoding RNA production in Arabidopsis thaliana. EMBO J 2011, 30(5):81422. 23. Zhang…
.95A - 0.0017 (R2 = 0.9997), exactly where C may be the quercetin concentration (g mL-1) and also a is definitely the remedy absorbance at 371 nm (linear variety: two…
Armaceutical Sciences 2013, 21:31 http://www.darujps/content/21/1/Page 7 ofTable 1 Cytotoxic activity (IC50, g/ml) of compounds 5a-k against different cell lines in comparison with etoposideO Ar MeOCompounds 5aHO MeOOMDA-MB-231 KB 36.85 two.97…
The 360 mg/m2 patients and 65 of placebo sufferers).and infections were similar amongst the epratuzumaband placebo-treated groups .PGA of illness activityBaseline values are shown in Table 1. The proportions of…
T test evaluation. The significant rise in the mucoadhesive nature of MOG is self-explanatory about the importance from the structuring of the edible oil within the microparticles. The results recommended…
N and a new peak (peak b) was produced. Peak ``a'' represents the substrate IBA. (B) LC-MS analysis of peak b. (C) LC-MS evaluation of IBA glucose conjugates developed by…
Containing damaged ancestral Icopies, at the same time as functional copies scattered along the chromosome arms. I-specific piRNAs in the ovaries of an I-strain exhibit the ping-pong signature (adenosine in…
Erated centrifuge (Hythe, Germany). The clear leukocyte cell lysates were stored at -80 till ABCA1 protein meaInt J Endocrinol Metab. 2013;11(2)3.5. Leukocyte ABCA1 Protein Expressionsurement was performed. Frozen leukocyte lysates…
D segment involves a gene, int1, encoding the integrase; attI, the cassette integration website; plus the promoter Pant, which can be accountable for expression of cassette genes. The 3 conserved…
Periodate oxidation, 1 mol of GalA residues in TPS1-2a and TPS1-2b consumed 0.97 and 0.98 mol NaIO4, respectively, in approximate accordance having a calculated value of 1, suggesting the linkage…
Ses on Vero cells have been measured and plotted as described within the legend of Fig. 2. Dark bars represent the median plaque size. The distinction among the HSV-1(F) BAC…
Medium for at the least 2 days before experiments. At 50 60 confluence, Transfection Medium was added ten min before transfection. Transfection complexes were generated in serum-free medium by mixing…
Raft-domain Src activation is linearly correlated in magnitude with FA disassembly at lamellipodia regions, and that Src activation precedes FA disassembly in minutes. This linear relationship involving two distinctive biochemical…
Rating mice with targeted deletion on the TBRII in myeloid lineages for future research to address this question in an in vivo setting of vascular injury. Recent findings from Pang…
Fficient = - 0.0040; R2 = 0.144 by generalized linear model) adverse association of IL-8 concentration with duration of injury in the time of sample acquisition. IL, interleukin.CYTOKINES IN CANINE…
Ed and solubilized with NETT lysis buffer, and protein concentrations have been measured prior to Western evaluation. (B) Band intensities were expressed as percentages of total levels (D, dimer; M,…
Roduces the gene product into a highly inflammatory region, which probably explains the poor cardiac gene therapy outcomes with IM interventions. Early research by Snyder et al. reported that incredibly…
Ology of Cyanobacteria; Blackwell Scientific Publications: Oxford, UK, 1982. 29. Gil, C.G.; Kim, Y.J.; Gu, M.B. Enhancement within the sensitivity of a gas biosensor by utilizing an sophisticated immobilization of…
Ine and age-10 follow-up measurements, even soon after adjusting for confounding aspects (Shalev et al., 2012). This locating supplied the very first proof that stress-related accelerated telomere erosion is often…
: de novo conserved regulatory motifs. Added file 13: Primer sequences for 5' and 3' RACE in D. galeata, C. dubia and M. macrocopa. Further file 14: Accession numbers of…
S for each of these isoforms indx.doi.org/10.1021/cr300163e | Chem. Rev. 2013, 113, 4633-Chemical Reviews diverse biological processes and can absolutely continue to uncover added avenues for therapeutic intervention for ailments…
. S1B). In contrast to the effect of IL-6, pyrimethamine had an inhibitory impact on the differentiation of Foxj1-GFP+ cells (Fig. S1A). Inhibition of ciliogenesis, but not Splunc expression, was…
Had been detected by flow cytometry and Elisa. (a) Dot plots displaying the percentages of VCAM-1 expression in HUVECs. (b) The VCAM-1 expression in different groups of HUVECs. (c) The…
N price is calculated as the percentage of cytosines sequenced at cytosine reference positions inside the Lambda genome. WBSA can approach single-end and pairedend information for WGBS, but only processes…
Eclines in visual working memory have been associated with elevations in sphingomyelin occurring later in therapy.91 Lipid peroxidation in CSF is regarded as an indicator of oxidative tension. Phosphatidylcholine and…
SPR based binding assay, the fractions P2-20 and P2-50 could possibly not be good candidates for further inhibitor purification, because it is not clear that the observed interaction can inhibit…
Urves for the parameters P(t) and R(t) working with a user-defined smoothing window, and (ii) calculation with the mean-squared displacement (MSD) of your centroids and fitting the resulting curve to…
F validation in which two unconditional criteria are evaluated to establish the prospective usefulness of a biomarker: sensitivity and specificity . Sensitivity is defined as the proportion of confirmed illness…
F clones had been derived from persons with known or suspected early infection, we indirectly assessed infection stage as a potential confounder by which includes Nef sequences from 52 contemporary…
C, an AMPK inhibitor, decreased the impact of AICAR on adiponectin mRNA expression (Figure six(c)). Compound C treatmentalso decreased the upregulated impact of TG or 2TG on adiponectin mRNA expression…
Care with the electrostatic and van der Waal's interactions in between protein and ligand. The DGsolv is estimated by solving the linearised Poisson Boltzman equation for each in the three…
Itatively in pure kind. We're conscious of only one preceding report on the reduction of tertiary amides (-hydroxy morpholinamides) toAngew Chem Int Ed Engl. Author manuscript; obtainable in PMC 2015…
2. expression of sPD-1 and sTim-3 mediated by rad5-sPD1 and rad5-sTim3. (A) schematic presentation of rad5-sPD1 and rad5-sTim3 carrying genes encoding sPD-1 and sTim-3. The coding sequences of sPD-1 and…
Astle illness virus (NDV), LPS, or IFN- (Fig. 5). Supernatants were collected following therapy and analyzed by multiplex ELISA. The proinflammatory cytokine IL-1 was marginally secreted by mock-infected and TB40/E-infected…
And the molecular mechanisms by which context imparts distinct properties to a method. Recent perform has offered some mechanistic insight. As an example, inside a single cell, associated kinases could…
D of P , 0.05 / 549,869 = 9.1 3 1028. Genotypes among males of X-chromosome SNPswere encoded in accordance with default PLINK settings (zero or one particular copy from…
And after one particular month in one case (9). In sufferers with renal cell carcinoma (RCC) treated with sorafenib, Johannsen et al (14) observed that recurrent or new metastatic lesions…
Positive regulator upstream in the Pmk1 in some strain circumstances (26, 42), even though its function in activation of Pmk1 in response to glucose starvation is debatable (27). Under typical…
Ed because the main antibody. ELISA assay. Cells had been plated in 6-well plates and incubated for 24 hours in starving media. Cells had been then stimulated with 40 ng…
Corded for every trial. To analyze these variables, a four-factor mixed ANOVA style involving between-group effects of drug remedy (pHBSP or manage), time of administration (early or late), repeated measures…
Iuk Wen-Horng Wang, Keerthi B. Jayasundera W. Andy Tao��, Carol B. Post and Robert L. Geahlen In the Departments of Medicinal Chemistry and Molecular Pharmacology and �Biochemistry along with the…
S (Figure 1C). P450 gene expression in liver tissue slices obtained from adult rats Transcript levels of cytochrome P450 enzymes involved inside the metabolism of PCB had been determined in…
Ther web sites. The involvement of SjS secondary to SLE, MS, and RA along with the fact that acrolein-conjugated proteins are a biomarker in SjS, might be attributable to polyamine…
Hydrolyzed, and in oneNIH-PA Author ManuscriptCurr Opin Biotechnol. Author manuscript; offered in PMC 2014 August 01.Schwartz and GuoPagecycle, six ATPs are expected to translocate dsDNA one particular helical turn of…
Study with all the natural adjuvants. Hence, these results also support the effects of those adjuvants around the serum levels ofIFNc and IL-4 as well as the IFN-c-to-IL-4 ratio within…
(Lim et al. 2004; Richard et al. 2008). Interestingly, the redundancy of MutSa (Msh2/Msh6) and MutSb (Msh2/Msh3) in recognizing a single-nucleotide insertion/deletion loop at homopolymeric runs (Acharya et al. 1996;…
Larly modulated and/or controlled by the same fusion machinery is debated: Exosome secretion by maturing reticulocytes appeared to depend on VAMP7 function (Fader et al., 2009), whereas in MDCK cells,…
PH partitioning of lipophilic amines into lysosomes. The diagram illustrates the mechanism by which lipophilic amines (i.e., CADs) accumulate in lysosomes. From plasma (pH 7.four) and cytosol (;7.two), a lipophilic…
10 occasions significantly less than wild-type activity. Interestingly, while all other mutant strains catalysed PCE reduction at rates related to wild-type, DSsed_2100 showed a slightly enhanced PCE transformation price (1.4…
Nternal fetal or uterine monitoring devices, spontaneous onset of labor, and meconium-stained amniotic fluid (25). The threat of EOS increases to 1 when membranes are ruptured 18 h before delivery…
E cholesterol can be a key threat issue for myocardial infarction in vasospastic angina with nearly standard coronary artery. Atherosclerosis 1998, 136, 22531. Ellsworth, J.L.; Fong, L.G.; Kraemer, F.B.; Cooper,…
Or study 2, baseline-corrected plasma TRL concentrations of b-carotene (Fig. 2A), a-carotene (Fig. 2B), and retinyl esters (Fig. 2C) right after consumption with the carrots with or without having avocado…
The hypothesis that Myb2 can activate transcription of the endogenous topo II gene. We expressed Myb2 in E. coli and purified it to .95 homogeneity to test the DNA binding…
Ing points working with Clifton Nanoliter Osmometer (Clifton Technical Physics, Hartford, NY, USA) as described earlier . In an effort to estimate loss of mass, water and lipid reserves in…
L and hypertonically-treated fish have been perfused with isotonic medium for 30 min, followed by infusion of gluconeogenic substrates (5 mM) for 30 min, and after that once more with…
Moderate to excellent conversions and high enantiomeric excesses. The asymmetric induction sense is fully controlled by appropriate selection with the metal complex, and enantioselectivity is unaffected, or small influenced, by…
L miRNAs had been found to be secreted selectivelyjvi.asm.orgJournal of VirologyEBV miR-BART15-3p Targets BRUCEFIG 9 Detection of miR-BART15-3p in exosomes isolated from EBV-infected gastric carcinoma cells. AGS, AGS-EBV, and SNU-719…
Hese. For potentially relevant sources, the full articles have been obtained and reviewed to establish regardless of whether prevalence information have been precise to patients with T2DM. Study particulars were…
Ta . These functions may be predominantly but not exclusively related with specific members with the fecal microbiota, which would then nonetheless show statistical correlations with wellness and illness states.…
To IFN-gamma and lipopolysaccharide by the STK/RON receptor tyrosine kinase. J Immunol 1999; 163: 6606613. 64 Ray M, Yu S, Sharda DR, Wilson CB, Liu Q, Kaushal N et al.…
S-NATs had been identified by RT-PCR amplification. In all, 189,348 smaller RNAs, 27,465 of which were distinctive, were derived from 6808 NATs. These compact RNAs have been found to become…
S this organism is intrinsically resistant to the other recommended Enterococcus treatment, quinupristin-dalfopristin.13 Much more serious and complex infections, for instance Enterococcus-mediated endocarditis, do not have a clear regimen of…
-mediated transcriptional induction system in transgenic plants. Plant J 11: 60512 Ballio A, Chain EB, De Leo P, Erlanger BF, Mauri M, Tonolo A (1964) Fusicoccin: a new wilting toxin…
Ding regions on plastid DNA utilizing cpChIP assays. We found that HSP21 and pTAC5 exclusively bound towards the promoter regions of PEPdependent psaA, rbcL, and rrn genes. For psbA, HSP21…
Oxifen had no effect on the acetylation state of this protein band. Subsequent, 2D Western blots had been employed for higher resolution evaluation of liver protein acetylation profiles (Figure 3B).…
Erms of accuracy or comfort when evaluating the improved volumetric flow price together with the FlexTouch compared with common mechanical pen injectors which include the SoloSTAR.Disclosures: Each authors are employees/shareholders…
R characterize the differentiation, we performed alkaline phosphatase assay and identified that the alkaline phosphatase activity was decreased but not enhanced, which suggested that FlnB loss promoted some but not…
To o500 cells ml inside the O2:N2 FCC (Figure 4a). Similarly, the numbers of CHAB have been similar throughout the experiment in all FCCs, with approximately four 103 cells ml…
Ases the danger of establishing MS ; EBV-specific CD8+ T cell responses are elevated during active MS ; and, ultimately, therapy with monoclonal antibodies that deplete the B cell reservoir…
Cle cells. EMBO J. 2010; 29:3184195. 42. Miller KG, et al. A genetic selection for Caenorhabditis elegans synaptic transmission mutants. Proc. Natl. Acad. Sci. U.S.A. 1996; 93:125932598. 43. Hammarlund M,…
E modulation of nociception. 5-HT1A receptors are enriched in (superficial) dorsal horn laminae involved in the processing of major afferent information , and that norepinephrine can act by way of…
Roaches could supply the much sought-after opportunity for early intervention, preservation of cognitive reserve capacity and prevention of irreversible cognitive decline in ageing.Author Manuscript Author Manuscript Author Manuscript Author ManuscriptPANELSearch…
IH-PA Author Manuscript NIH-PA Author ManuscriptWith weekly inotuzumab, previously observed prominent negative effects connected with singledose inotuzumab had been less frequent, in distinct fever and hypotension within 48 hours of…
En Challenge Reduces Little Airway ReactivityFigure 3. Comparison of small airway responses to methacholine (MCh) in lung slices from saline (SAL)- and ovalbumin (OVA)challenged mice. a) Representative photos of MCh-induced…
The future research with LC.Abbreviations CKD-MBD: Chronic kidney disease mineral and bone disorder; ESRD: End-stage renal illness; LC: Lanthanum carbonate; RCT: Randomized controlled trials; iPTH: Intact parathyroid hormone; CC: Calcium…
61 cells (Fig. 4A). Although PD98059 inhibited P-ERK1/2 in all the cell lines tested, MEK targeting did not efficiently block clonogenic activity (Fig. 4B): a slight impact was only observed…
Members in the Populus genus. Even so, the chemical composition of A. mellifera propolis has been located to be really difficult with greater than 300 identified compounds, for instance polyphenols,…
Ain inhibitor, decreases beta catenin degradation by proteasome and calpain . Lastly, JAK2 activation enhances beta catenin activity and induces SET-mediated inactivation of PP2A thereby precluding PP2A-induced activation of GSK3…
Rs similarity and differences among Burkitt lymphoma subtypes. Blood 2011, 117:3596608. 11. Lenze D, Leoncini L, Hummel M, Volinia S, Liu CG, Amato T, De Falco G, Githanga J, Horn…
E bloodSawada H, Oeda T. BMJ Open 2013;three:e003533. doi:ten.1136/bmjopen-2013-ETHICS AND DISSEMINATION In line with `Good Clinical Practice (GCP)' released by the Ministry of Wellness, Labor and Welfare, all participants will…
The endogenous reference gene, GAPDH. The CT is defined because the fractional cycle number at which the fluorescence generated by cleavage of the probe passes a fixed threshold baseline when…
He basic population mortality . Provided that only three deaths were reported inside the 1118e trial , long-term projection on the trial information was not feasible. The mortality through PFS…
S (EIN3/ EIL1) mediates jasmonate and ethylene signaling synergy in Arabidopsis. Proc Natl Acad Sci USA 108(30):125392544. 40. Parra M, Verdin E (2010) Regulatory signal transduction pathways for class IIa…
Ile permitting for any controlled price of drug delivery . Passive approaches, for example penetration enhancers, result in skin irritation and are restricted to only compact molecules . Other active…
Ry, University of Gdansk, ul. Wita Stwosza 63, 80-308 Gdansk, Poland; [email protected] Correspondence: [email protected]; Tel./Fax: +48-58-349-Academic Editor: Ting-Li (Morgan) Han Acquired: five December 2016; Accepted: 19 January 2017; Published: 29…
Ble three) (37, 52). PCR mixtures contained template gDNA, 0.15 M each and every primer, and 1 SensiMix (SYBR No-ROX kit). The reactions were performed at 56 for primer annealing…
On is mediated by a ligand-gated ion channel called GlyR, pharmacologically characterized by strychnine sensitivity, and primarily localized in the spinal cord where it plays an important function in nociceptive…
Hibi tion. In nonsmall cell lung cancer, mesenchymal cell lines (defined as expressing Ncadherin and Vimentin) exhibited marked resistance to targeted therapies towards the EgFR and also the PI3K/AKT pathways…
Ng (scRNA-seq) of stimulated PBMC from kidney transplant recipients with subclinical rejection with and with out tocilizumab therapy, showed that tocilizumab-treated PBMC had decreased expression of inflammatory-mediated genes and biologic…
Rol). Various symbols (circle/square) had been applied to represent the information points of independent biological repeated experiments. All data are displayed as mean SEM; n = 3; p 0.05, p…
Superimposition of Screened Drugs within the Active Region on the EWS Protein. All the docked structures had been superimposed to verify the binding configurations of all five screened drugs inside…
Sk. In the nighttime, these percentages were 16.33 , 15.35 and 68.32 , dusk. Within the nighttime, these percentages have been 16.33 , 15.35 and 68.32 , respectively. respectively.80 Resting…
Es are mostly focused on alanine-scanning mutagenesis, directed evolution, fusion proteins constructs by way of artificial linkers, and directed localization in the enzymes by way of signal peptides. As a…
, 14,1501456 of3. Final results three.1. Polymer Selection3. Benefits 3.1.1. Hansen Solubility Parameter 3.1. Polymer Choice 3.1.1. Hansen Solubility Parameter The structural formulaof AZI is shown in Figure 2. The…
(S/R) progressively appeared (Figure 9C). at 35 and pH 5.0. the resultant minor sidase enzyme on saponin occurred As shown in Figure 9D, The identified strain UR ginsenosides Rg5, Rd,…
Ilms . A microbial biofilm can be a three-dimensional collection of microbial cells enclosed within a self-produced matrix that protects it in the harsh environment. The matrix-enclosed communities of bacteria…
0b versus mortality . In contrast for the present study, biomarker values from a number of timepoints had been pooled for assessment of ROC. The paper by Fink et al.…
R than the other subclone mean IC50 values and was excluded from additional experiments because of this. The selected subclones stably overexpressed the fluorescent ZsGreen protein as previously described (Fig…
Iple sterile pustules normally 24 mm in diameter occurring around the palms and soles. Occasionally, lesions may be located on the dorsal aspect of the hands and feet at the…
Lycemic response than WT-CAF mice adjusting the weight (WT-SD 46.246 4.302 vs. B1RKO-SD 35.699 three.383; p = 0.03; and WT-CAF 56.564 three.477 vs. B1RKO-CAF 28.521 five.338; AUC ANCOVA, p =…
Hat most "unfit" patients weren't expected to acquire deep remissions with low-intensity obtainable remedies, for instance the hypomethylating agents (HMA) azacytidine (AZA) and decitabine (DEC), and with low-dose cytarabine (LDAC),…
Ed cells (Figure 3C) compound was chosen for further investigation on the mechanism of action in GBM the Upon one hundred M6treatment, compound six showed 11 development inhibition againstcells.growthof non-tumorousof…
Nt study to investigate which also means on is specifically composition of intestinal microbiota in rats. Our results suggested that BPA exposure susceptible to injury from xenobiotics and disturbed gut…
Ed compounds and optimistic and unfavorable controls.AUC equivalent towards the manage. Though these outcomes are within error, they suggest that six inhibits and 9 stabilises tubulin polymerisation (Fig. 5A and…
Ed to adjust the electrode surface kinetics toward detecting only the DA molecules as opposed to the other people. For the duration of the synthesis process, some achieved functional monomer…
Xynucleosides (cPu) are solely generated by the attack of HOradicals on purine moiety through C5 -radical chemistry, resulting in the formation of an more C5 -C8 covalent bond; 5 ,8-cyclo-2…
Cialy obtainable kits (Elabscience Biotechnology Co. Ltd.). Identical protocols was followed for figuring out levels of those protein elements inside the serum samples of the participants. Briefly, 100 L of…
E LBD is transmitted to the N-terminal DBD and that the differences inside the activity of AdmX in the presence of IAA and IPA are usually not reflected in major…
Olcs Rudn , Sruthy Maria Augustine and Kaushal Kumar Bhati Received: 28 November 2022 Revised: ten January 2023 Accepted: 12 January 2023 Published: 15 JanuaryAbstract: Haberlea rhodopensis is a exclusive…
;60(12):789-795. 19. Chui MH, Chang JC, Zhang Y, et al. Spectrum of BRAF mutations and gene rearrangements in ovarian serous carcinoma. JCO Precis Oncol. 2021;5:PO.21.00055. 20. Stangl C, Post JB,…
T biomarker in HN (Figure 4A, histogram of the LDA scores is shown in Supplementary Figure S3A).Frontiers in MicrobiologyFor the fungal microbial neighborhood, a total of 28 significant biomarkers were…
Heir discussed interpretation. Fusui Ji jifusuivip@126Department of Cardiology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Healthcare Sciences, 100730 Beijing, P. R. Chinacan inhibit neointimal…
7, 2013 Nov eight, 2016 Sep 20, 2017 Dec 18, 2014 Aug 25, 2009 Feb 15, 2011 Jan 5, 2010 May 10, 2010 Aug 16, 2017 Feb 18, 2010 Nov…
0.05), and PL therapy alone noticeably decreased TYR mRNA level (p 0.05) and had no important impact on TYRP-1 mRNA level in B16F10 cells (p 0.05). Moreover, compared using the…
E. McDonald Camille Paynter Jill J. Francis Daevyd Rodda Supreet Bajwa David Story orcid.org/0000-0001-9518-5869 orcid.org/0000-0002-1845-126X orcid.org/0000-0001-5784-8895 orcid.org/0000-0001-8941-8224 orcid.org/0000-0003-2325-7653 orcid.org/0000-0002-6479-16. 15. 14. CANCER GENOMICS PROTEOMICS 19: 624-635 (2022)doi:ten.21873/cgp.Analysis of Protein rotein…
five -monophosphate (5 -UMP) belong for the class of pyrimidine ribonucleotides. Pyrimidine ribonucleotides consist of a phosphate group, a pentose sugar ribose, along with the pyrimidine nucleobase. 5 -CMP and…
Pyrazolone pharmacophore. Their diverse biological activities encouraged us to synthesise a series of pyrazoloneRSC Advances analogues with prospective anti-SARS-CoV-2 activity. Molecular docking analyses had been performed with viral S, Mpro,…
E 2,6-linked SLN (see Supporting Info section six.3 and Figure S8). Normally, lower STD intensities have been observed together with the sole NTD than together with the significantly larger trimeric…
Cns||LI et aL.dimorphism in parasympathetic domination of blood stress regulation through activation of B2R/B1R expression in baroreflex afferent pathway.KEYWORDSbaroreceptor activation, bradykinin, depressor response, neurocontrol of blood stress regulation, nodose1 |…
With ERa and beta-catenin to modulate distinctive gene expression.22 In ER-negative basal-like breast cancer, EZH2 transcriptionally activates NF-kB independently of your RPC2 complex.17 Furthermore, in triple-negative breast cancer (TNBC), EZH2…
Eived no external funding. Institutional Critique Board Statement: Not applicable. Informed Consent Statement: Not applicable. Data Availability Statement: All information and information reported within this post are going to be…
(cryo-SEM) (Hitachi FlexSEM1000, Japan) in line with the protocol described by Kumar et al. (2012). The stomatal length, width, and density measurements were performed employing ImageJ software1 .Hormone AssessmentFor hormonal…
Els in BALF specimens obtained from sufferers with CTD-ILD and control individuals with community- cquired pneumonia (CAP). Utilizing bioina formatics analyses, we aimed to identify prospective biomarkers of CTD-ILD and…
E, requiring only the space available to execute it. The artificial one makes use of dryers inside a warehouse . On the list of most significant parameters to handle is…
Serum also induces liver fibrosis by means of evoking an immune reaction but devoid of hepatic necrosis, that is distinctive from HPV-induced liver fibrosis (Bhunchet and Wake, 1992). Dietinduced models…
In this trial (13). Additional comparability of EPIC trial participants to OPTIMIZE participants was assessed making use of criteria supplied by Pocock (Table 1) (14). The OPTIMIZE trial was stopped…
Ely accepted and utilised industrial software program for glycopeptide identification.29 It features a peptide centric nature; 1st, it searches the peptide component and handles the glycan as a (in some…
Been RPP had been measured. Right after the animals had and within a stable haemodynamic condition for at least 15 min,baseline values of SBP, HR, and RPP had been measured.4.3.1.…
Ression . Our findings contrast with earlier research reporting that elevated consumption of caffeine, which is also a methylxanthine, is related with decreased threat of depression . Indeed, a study…
D the higher the levels of CCL15 or CD163 have been, the worse the OS and RFS on the individuals (Figure 4C-F). Furthermore, the combined predictive worth of CCL15 and…
Le + WD therapy increased LC3II/LC3I ratio (225 ) and p62 (267 ), and decreased Beclin1 protein levels (54 ), thereby indicating autophagosome accumulation (Fig. 6B). AntiOxCIN4 supplementation in WD-fed…
Mg/L (Figure genotype strains had metronidazole MIC valuesstrains valueshad metronidazolevalues (Figure 64 mg/L (Figure 1c). These strainsstrains were have been genotype strains hadgenotype genotype mg/L (Figuremg/Lmetronidazole 64strainsmg/L (Figure 1c). These…
Gnetic Kit (Epicentre, Madison, WI, United states of america). Following this, the enriched mRNA was fragmented making use of the fragmentation buffer, and reverse transcription was performed making use of…
Ble 1 and are derived from this study or prior perform as indicated . 2.3. Microscopy Osteoclast-like multinucleated giant cells have been deemed as cells with 3 or extra nuclei.…
Plus (Illumina, Inc., San Diego, CA) workflow. In lieu of bacterial rRNA depletion with Ribo-Zero Plus, the Qiagen FastSelect--5S/16S/23S kit (Qiagen Sciences, Germantown, MD) was employed with the modification of…
Les and SASA were completed employing a pool of in-house scripts based on tcl embedded in VMD (Humphrey et al., 1996). The residues interacting with all the ligand had been…
Henolic compounds, and antioxidants . Inside the final handful of years, agrochemical-based production schemes have helped to increase the yield on the cucumber crops by three, nevertheless, synthetic fertilization has…
550. 49. Kuleshov MV, et al. Enrichr: a comprehensive gene set enrichment evaluation web server 2016 update. Nucleic Acids Res. 2016;44(w1):W90 97.J Clin Invest. 2022;132(18):e148141 doi.org/10.1172/JCI Copyright: 2022 by the…
Cute (by way of Trier Social Anxiety Job; TSST) and diurnal patterns of anxiety method responding in a low-income sample of African American emerging adults, predominately living in an urban…
Sates and mitochondrial lysates have been resolved by SDS-PAGE and transferred to PVDF membranes. Membranes have been blocked for 1 hour in 5 BSA in TBS-T, incubated with key antibody…
Heir extracellular ligands with IgL domains, subsequent receptor dimerisation, cross-autoactivation of TKD, and downstream signal transduction . The first organic ligands of TAM receptors, i.e., Development Arrest-Specific 6 (GAS6) and…
Ded by the European Social Fund. Conflicts of Interest: The authors declare no conflict of interest. Annals of Medicine and Surgery 75 (2022)Contents lists available at ScienceDirectAnnals of Medicine and…
C-MET, and yes-associated protein (YAP) signaling pathways . IGF1R was upregulated in ALK TKI-resistant cells, and when stimulating cells pretreated with crizotinib with IGF1, ALK phosphorylation was inhibited. Ceritinib can…
E employed for qPCR evaluation. Fig. S1. The results of sucrose preference inside the SPT. The sucrose preference within the SPT was significantly decreased in CPS-treated mice in comparison with…
MiRPathDB, mpd.bioinf.uni-sb.de/mirna. htmlmirna=hsa-miR-155-5p organism=hsa, hg19_CLIPseq_miRNA, and miRTarBase) revealed that miR-155-5p could target the following cell cycle-related and proliferation-related genes: CDK2, CDK4, CCND1, and CCND2. 2.9. Gene Ontology (GO) and Kyoto…
Mation , HSYA lowered proinflammatory cytokines production and combated oxidative tension, getting a contribution to stopping the damage to cerebral microvessels. NOXs also contribute to neuroinflammation and neuronal hyperexcitability in…
93 sirtuininhibitor1.69 mV, psirtuininhibitor0.01). Activity was improved compared to the optimistic handle (forskolin, -1.65 +/- 1.78 mV), even though this was not statistically considerable (Figure 7A and 7B). CFTR is…
Mass spectrometry evaluation. Next, we alsoCELL CYCLEFigure 4. DCAF11 interacts with wild kind, but not Thr 61/Ala mutant SLBP. (A) HeLa cells were transfected with HA-DCAF11 along with hisSLBP. Cells…
Iao (9) hui (ten) huang (11) ther minority Consuming and sanitation (12) Wash hands just before consuming (13) Wash hands immediately after making use of toilet (14) Under no circumstances…
AKP-11 is just not a pro-drug, rather it is actually a direct agonist of S1P1 receptor (Fig 8) Recently, two other S1P1 agonist butterfly compounds ST-968 and ST-107 had been…
-6.02 -9.87 -7.83 -16.77 -24.65 +3.14 -31.37 -19.06 +12.74 -6.93 +1.65 +12.29 +8.74 P-value ns ns ns ns Psirtuininhibitor0.05 ns Psirtuininhibitor0.05 Psirtuininhibitor0.01 ns Psirtuininhibitor0.01 Psirtuininhibitor0.05 ns ns ns ns ns…
Me of reagent needs to be used when supercharging with these two new reagents on instruments with gentle supply situations for optimal protein ion signal. Supercharging in buffered solutions Buffers…
D to tolerate and caused interference with activities of each day living and/or sleeping). Safety variables Adverse events, nasal examination findings and crucial indicators have been assessed. These data are…
T, J = 7.five Hz, two H), 1.51.61 (m, 2 H), 1.40.49 (m, two H), 1.36 (d, J = 7.0 Hz, 3 H), 1.26 (br. s, 20 H), 0.90 (t,…
Ina) amongst June 1997 and April 2003 were retrospectively investigated. All integrated patients met the following inclusion criteria: (1) histologically confirmed colon adenocarcinoma; (two) pathologic stage I II ailments in…
Esearches in Poland."Imidazoline DerivativesClonidine hydrochloride, BRL44408 maleate, JP1302 dihydrochloride, ARC239 dihydrochloride, and RX821002 hydrochloride had been purchased from Tocris (Bristol, United kingdom). Yohimbine hydrochloride was obtained from Sigma-Aldrich (St Louis,…
BCRP. Quantitatively, we saw no transform within the certain activity of those transporters (Fig. 3C). Mainly because C1P exposure elicited no changes to these transporters, we focused exclusively on P-glycoprotein…
H just after HSV1 infection. , P 0.05; , P 0.01; , P 0.001; , P 0.0001, unpaired Student's t test (A , H, and I), log-rank (Mantel-Cox) test (E…
C Natl Acad Sci U S A. 2008;105(48):18782. Tanida I, Minematsu-Ikeguchi N, Ueno T, Kominami E. Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for…
Ance of SLFN11-negative cells to PARPIs.Clinical implications of SLFN11 for precision medicineA notable consideration is the fact that the impact of SLFN11 is dependent on PARP trapping, which is determined…
29sirtuininhibitor3,52]. Though tryptic digestion did not create fragments smaller enough to permit precise assignment of your phosphorylated residues between S224 and T244 (as is widespread in mass spectroscopy experiments), evaluation…
Rud, J.E., Chiu, D.S., Usui, M.L., Gibran, N.S. and Ansel, J.C. (1998) Protein gene solution 9.five is expressed by fibroblasts in human cutaneous wounds. J. Invest. Dermatol. 111, 56572 CrossRef…
Val curves based on p53 antibody status for the entire population (n = 90)p53 with the individuals was detected in 63 (38/60). There was no important distinction in background amongst…
Taken at the identical settings employing a Zeiss confocal microscope. (C) Ponceau S staining of the purified proteins and their quantities used within the pulldown assay. The asterisk indicates purified…
Ee independent experiments (biological replicates) and also the error bars represent the normal error of independent experiments (biological replicates) plus the error bars represent the standard error of the the…
Iciency around the outcome of elderly patients with diffuse significant B-cell lymphoma was investigated. 359 pretreatment 25(OH)D serum levels from the RICOVER-60 study (six vs. eight cycles of biweekly CHOP-14…
Ion HCV protease inhibitor simply because its binding affinity and specificity for NS3/4A is higher than that of first-generation protease inhibitors that have a linear structure. It has been approved…
Played smaller PMN extravasation, with equivalent behavior towards the negative manage, indicating that rCeEI and CeKI had been efficient in minimizing PMN migration in to the BALF. The mechanism utilized…
IbutionsConceived and designed the experiments: DPC MAM IW. Performed the experiments: DPC FJD. Analyzed the data: DPC FJD MAM IW. Contributed reagents/materials/analysis tools: IW. Wrote the paper: DPC MAM IW.…
Dia and facial swelling (13.95 ). Blood testing of antimony remedy unwanted side effects on renal function showed no alteration in blood urea nitrogen (BUN), nor in creatinine levels. Having…
Et al., 2000)ZFIN ID: ZDB-GENO-960809-7 ZFIN ID: ZDB-FISH-151204-7 ZFIN ID: ZDB-FISH-150901-28454 ZFIN ID: ZDB-FISH-150901-6828 ZFIN ID: ZDB-FISH-150901-(Cambier et al., 2014b) (Cambier et al., 2014b) (Ramirez-Carrozzi et al., 2009) (Ramirez-Carrozzi et…
Optosis in A2780 and OVCAR3 cells within a dose-dependent manner (Fig. 2a ), an impact higher than that of DHA at the identical concentration (Fig. 2d). By comparison, typical cells…
Eded. One such agent is definitely the selective estrogen receptor modulator raloxifene, which was shown to act as an estrogen receptor agonist in the brain (and bone) and antagonist in…
L function for the ligands of inhibitory receptors like CD200R, CD300a, or CD300f could possibly be to contribute to the so-called "On" and "Off" signals . "Off" signals are constitutively…
Rvival as function of PTEN expression inside a cohort of neuroblastoma patient samples (498 samples) or perhaps a subgroup of it, as indicated. (D) Plots showing PTEN expression on unique…
Consumption]. Physique composition was determined at 4, eight, and 12 weeks by magnetic resonance imaging utilizing an EchoMRI-100 instrument (Echo Medical Systems, Houston, TX). Mice have been removed from group…
Tidase E; cathepsin B; tripeptidyl peptidase I PEDF; TIMP1,2; PAI-1, 2; cystatin CGO:0008233 peptidase activity GO:0004866 endopeptidase inhibitor activity GO:0001568 blood vessel developmentN-cadherin; thrombospondin 1, 2; biglycan; lysyl oxidase Fibulins…
Data help the hypothesis that colibactin-producing bacteria can play an important part in CRC. Preceding operates have shown that pksC E. coli can induce DNA harm major to mutations and…
State cancer, is induced by docetaxel and diminishes its efficacy by transporting it across the cell membrane . Our results indicated a marked upregulation of ABCB1 in resistant cells, which…
T 72 h. BBB permeability in the cerebral cortex of the neonatal rats, brain water content material and AQP-4 expression in the drug group had been drastically reduce than these…
Tration of ten mg/mL, EPS exhibited the antioxidant activity of a 100 , that is the identical as the scavenging activity of vitamin C. This outcome indicated that the EPS…
0 minutes soon after aortic cross-clamp removal on myocardial overall performance in 30 individuals with LVEF 40 undergoing elective CABG.20 Cardiac index (CI) was drastically larger within the sodium nitroprusside…
WT, RHEB Y35N, and KRAS G12V, and monitored cellular transforming properties by means of cell proliferation, anchorage independent development, cell cycle evaluation, and foci formation assays. Results: We observe a…
Er29 and is associated with autophagy in the hypoxia model.30 The outcomes demonstrated that Bnip3 expression was drastically enhanced following remedy with FSH and CoCl2 when compared with that in…
Tly, on tyrosine or leucine residues that are not integrated inside a classical YXX, D/EXXXL/LI or DXXLL setup for sorting to endolysosomes, including VAMP7 and LAPTM5. VAMP7 is usually a…
Hat the levels of GATA4 and Nkx2.five bound with Gcn5 progressively improved following Islet-1 infection, which was constant together with the elevated expression of Gcn5 (Fig. 4B). The binding levels…
Lution. Dithiothreitol was added to a final concentration of 5 mM and also the resolution was incubated at 56 for 30 minutes. The sample was then cooled to area temperature…
Al usages, offered the original operate is properly cited.radical reaction by collecting pro-oxidants or chelating transition metal ions (6). The ROS, such as the superoxide anion, hydrogen peroxide and hydroxyl…
Interestingly, vehicle treated GMH animals showed a compact tendency towards having elevated CD206 expression levels, which also did not reach a statistically substantial distinction when compared with 15d-PGJ2 treated GMH…
Is recognized to play an essential role in programmed cell death (PCD) or apoptosis.1,two Bax belongs for the Bcl-2 household of proteins, that are an evolutionarily conserved loved ones of…
Otal variety of live cells divided by total number of cells (stained) and multiplied by 100.Flow cytometric evaluation of cell viability by Propidium Iodide (PI) staining. 24 hours following incubation…
Sed. Nonetheless, this really is misleading considering the fact that being a CF carrier will not be a disorder, but rather it really is an indication, or marker, of increased…
Challenges within the greenhouse-based vegetable field, including the phenomenon of acidic soil as well as the secondary salinization of soil . These complications brought on by unreasonable use of nitrogen…
Years, along with the majority in the end succumb to HCC recurrence in the liver (2,three). Despite the fact that the high rate of tumor recurrence could possibly be a…
Ion to characterize RIZ1 function the molecular mechanisms underlying spermatogonial cell transformation. NewNew insights, one example is, could arise by using animal tumor models to evaluate cell transformation. insights, one…
Rk formation (SI Appendix, Figs. S7S9). When P1 was replaced with a larger silica NP size of 200 nm (P200 ), the assembled hydrogel became weaker (as shown by the…
Uch as colorectal cancer, gastric cancer, cervical cancer, breast cancer, and synovial sarcoma, whereas the precise outcome of FZD10 in RCC largely remains obscure. Tumor development may be attenuated by…
S an optimal amount of AMPK activity that's between additionS an optimal level of AMPK activity that is among addition of antagonist and addition of two agonists. In order to…
Erconnectivity within the DMN, alongside enhanced RSFC inside the affective and control networks, but hypoconnectivity within the focus networks in adults with ADHD. Sample heterogeneity with regards to psychotropic exposure…
Entration-dependent. The constitutive isoforms eNOS and nNOS are tightly regulated by Ca2+/calmodulin, and generate low flux (pM) NO over quick periods of time. In contrast, the inducible isoform iNOS is…
M values of mutants G10A (0.57 0.02) and Y24F (0.68 0.02) agree reasonably effectively with simulation, but we observed that neither mutation is ideal for transition state mapping. Surface-exposed G10…
Nding an alternative process for diagnosis of MPE is of good significance now. Exudative pleural effusion is a kind of protein-rich fluid, the majority of that are higher abundant proteins…
Pt vs. F20 blank, F30+Apt vs. F30 blank and so on). The surface charge with the hybrid nanoparticles decreased soon after siRNA incorporation was on account of the partial neutralization…
Mic attack. Lancet. 2001;358(9287):10331. 22. Dahlof B, Devereux RB, Kjeldsen SE, Julius S, Beevers G, et al. Cardiovascular morbidity and mortality inside the Losartan Intervention For Endpoint reduction in hypertension…
S the above, has alerted the impact of the exposure to SVOCs in property dust on childhood asthma or allergies. It has been recommended that youngsters are far more vulnerable…
Macol. Author manuscript; offered in PMC 2015 August 01.Stark et al.PageCZC24823 reduced the improvement of collagen induced arthritis (CIA) , and genetic too as pharmacological inhibition enhanced symptoms in the…
573.six, 852.three) 51.1 (44.0, 58.1) 52.two (44.7, 59.7) Moderate, N = 29 372.1 (196.5, 547.7) 391.2 (200.3, 582.1) 28.7 (19.0, 38.four) 25.8 (15.five, 36.1) Extreme, N = 30 239.9 (67.three,…
Entary Fig. 3B) was also noticed when excluding entirely hypo- (0 ) and hypermethylated (one hundred ) CpGs in each approaches, indicating accuracy in measurement for CpGs with intermediate methylation…
Ulations within the samples (Fig. 2a). The addition on the hydrophobic PI irgacure I651 in to the surrounding oil phase at a final concentration of three g/mL supported the cross…
Lies to the data produced readily available in this short article, unless otherwise stated.Fontana and Cappelli BMC Nephrology (2016) 17:Web page two ofBackground Because its initial description by Starlz in…
E also previously discovered reinforced extrinsic apoptosis signaling in an in vivo ALS model in the course of GSK-3 inhibitor therapy . In this study, we confirmed activation on the…
Nd/or resistance to pentavalent antimony compounds we may possibly use intralesional administration of ZS, it could worthy to mention that though pentavalent antimony compounds are pricey and their administration could…
O interact with full-length RNF31 (RNF31 FL) and RNF31 NT (containing the ZF domain) but not with RNF31 CT (Fig. 6A, top). Binding potential was recovered when RNF31 CT was…
Onto a 50 m pinhole. Donor and acceptor fluorescence was separated withOnto a 50 m pinhole. Donor and acceptor fluorescence was separated using a dichroic mirror (Chroma: ZT633rdc-UF1) and filtered…
Nors in SCHH. Total endogenous bile acid content material comprised the sumNors in SCHH. Total endogenous bile acid content comprised the sum of CA, glyco-CA, tauro-CA, CDCA, glyco-CDCA, and tauro-CDCA.…
En University TRXR1/TXNRD1 Protein Molecular Weight College Hospital, 235 Euston Road, London, UK Norgine Ltd, NorgineEn University College Hospital, 235 Euston Road, London, UK Norgine Ltd, Norgine Residence, Widewater Place,…
KY60, bind towards the CRK5 promoter, which can be consistent with informationKY60, bind to the CRK5 promoter, that is constant with information from the yeast-one hybrid, but not entirely consistent…
Le study, as well as the results are unlikely to be confirmed inLe study, and also the benefits are unlikely to become confirmed inside a potential manner. Even so, if…
He diagnosis, alleviation and treatment of AIDS, and microRNAs can prospectiveHe diagnosis, alleviation and treatment of AIDS, and microRNAs can potential to become utilized as a brand new target for…
Activation. Enhanced CD40 is also necessary for DCs to get additionalActivation. Elevated CD40 is also vital for DCs to receive further activation signals from CD4+ T helper cells. Blank DOTAP…
Ctivities and potencies of (2S,6S)-HNK and (2R,6R)-HNKCtivities and potencies of (2S,6S)-HNK and (2R,6R)-HNK are at the moment below investigation along with the outcomes of those research will be presented elsewhere.Author…
S effects on the proportion of splenic CD4+ T cells expressingS effects around the proportion of splenic CD4+ T cells expressing TFH markers. Effects of PR deficiency on splenic expression…
He 4 SET1 members of the family we characterized with kcat value ofHe four SET1 family members we characterized with kcat worth of 1200 six 200 h21 for pentameric complicated.…
Arm C for interferon-a (9 mIU 3 times per week) and bevacizumabArm C for interferon-a (9 mIU 3 times per week) and bevacizumab (10 mg kg sirtuininhibitor1 just about every…
Experiment. XD proposed and supervised the analysis, and provided important commentsExperiment. XD proposed and supervised the analysis, and provided worthwhile comments on the manuscript. All authors read and authorized the…
Had catheter ablation within 2 months prior to the index medication andHad catheter ablation inside two months before the index medication and people who had cardioversion 1 month before and…
Emical analyzer (Olympus, Tokyo, Japan). Serum TNF-, IL-1 and IL-6 levelsEmical analyzer (Olympus, Tokyo, Japan). Serum TNF-, IL-1 and IL-6 levels were determined employing enzyme-linked immunosorbent assay (ELISA) kits (Boster…
Y 10 of cultivation cell onplants with volumes of 20 l had been appliedY ten of cultivation cell onplants with volumes of 20 l had been applied on vascular branches…
Ny 12-month persistence Denosumab, i.v. ibandronate, i.v. zoledronic acidNy 12-month persistence Denosumab, i.v. ibandronate, i.v. zoledronic acid, Oral alendronate, Oral ibandronate, Oral risedronate, 2-year persistence Denosumab, i.v. ibandronate, i.v. zoledronic…
Entered the trials (median of 3 prior therapies). In an analysisEntered the trials (median of three prior therapies). In an evaluation of RESONATE and RESONATE-2 patients, 23 patients who had…
Corresponding genotype at 0 M ABA, which can be taken as one hundred . Values areCorresponding genotype at 0 M ABA, which is taken as 100 . Values will be…
In Chem. 1998;ten(1):21sirtuininhibitor. Planet Health Organisation: Quantifying selected big dangers toIn Chem. 1998;10(1):21sirtuininhibitor. Globe Overall health Organisation: Quantifying selected big risks to well being. In: The Globe Well being Report…
Cl-x RNA Splicingworkers (16) in further cancer varieties at the same time as inCl-x RNA Splicingworkers (16) in extra cancer sorts also as in vivo models. As a result, regulation…
Asizes the need to create distinct scoring systems for fibrosis inAsizes the have to have to create distinct scoring systems for fibrosis in chronic viral hepatitis and NAFLD . Till…
Decreased c-Myc protein levels and inhibited GSC proliferation (Fig. 4, E andLowered c-Myc protein levels and inhibited GSC proliferation (Fig. four, E and F). In vivo bioluminescent evaluation confirmed that…
Basis(ten). These findings are comparable to our final results which demonstrated thatBasis(10). These findings are similar to our outcomes which demonstrated that these lean ladies who consumed greater proportion of…
Rat SLPI Protein Accession Cortical Neurons. Finally, the effects of Rg1 on PPAR andRat Cortical Neurons. Finally, the effects of Rg1 on PPAR and NF-B 65 expression had been evaluated…
Activity based on luciferase assays in HeLa cells, as well as the ethanolicActivity depending on luciferase assays in HeLa cells, plus the ethanolic extract competed with DHT for binding to…
Ost three decades ago, the enzymes accountable for this modification haveOst 3 decades ago, the enzymes responsible for this modification have only extremely not too long ago been discovered by…
9 gene) (accession No.: KR184670), m138 gene (accession No.: KR184671), m144 gene9 gene) (accession No.: KR184670), m138 gene (accession No.: KR184671), m144 gene (accession No.: KR184672), m152 gene (accession No.:…
C TAT GCA CTG GGT GAA GCA GA CAC CCG TCTC TAT GCA CTG GGT GAA GCA GA CAC CCG TCT AGC AGT GAT GA CAC TTG GAA TGC AGG…
Nhibitor). This problem has received a lot interest especially because it relatesNhibitor). This issue has received significantly consideration particularly because it relates towards the study of functional sympatholysis in both…
Uteroglobin/SCGB1A1, Mouse (HEK293, His) Ferative ability with the 4 urolithins . In this study, UAFerative capability of your 4 urolithins . In this study, UA at 10M and 50M induced…
Tracts and lobules, inducing fibrosis which is mainly periportal . Instead, inTracts and lobules, inducing fibrosis that may be mainly periportal . As an alternative, in steatohepatitis the overall location…
Eliminated. As a proteinbased subunit vaccine (Moyle and Toth, 2013), PzE doesEliminated. As a proteinbased subunit vaccine (Moyle and Toth, 2013), PzE will not cause genome insertion, a threat related…
Atment inhibited caspase-3 cleavage andCHUNG et al: Combination Treatment WITH MORInAtment inhibited caspase-3 cleavage andCHUNG et al: Combination Remedy WITH MORIn AnD MST-312 In COLOReCTAL CAnCeRFigure six. Cell viability is…
ActinMaximum sensitivity substrate kit (Thermo Scientific, Logan, UT); immunohistochemical (IHC) analysisActinMaximum sensitivity substrate kit (Thermo Scientific, Logan, UT); immunohistochemical (IHC) analysis reagent EZ-Dewax (Biogenex, Fremont, CA); background sniper, polymer and…
GH content material, across bacterial phyla (S4 Fig). In most phyla, theGH content, across bacterial phyla (S4 Fig). In most phyla, the taxonomic origin, not the ecosystem, was a major…
L: IFIT3) and normalized for the housekeeping gene Rpl8. Information isL: IFIT3) and normalized towards the housekeeping gene Rpl8. Information is shown as mean SD and combined from three independent…
Manuscript Author Manuscript Author Manuscript Author ManuscriptLUO et al.PagePai1-Manuscript Author Manuscript Author Manuscript Author ManuscriptLUO et al.PagePai1-/- donor/Pai1-/- recipient) mice. As a entire, these in vivo results support a vital…
Atment reduction of GSH along with the elevation skin (FigureNO in theAtment reduction of GSH and the elevation skin (FigureNO inside the skin. partially prevented the reduction of GSH along…
A monotherapy, constant with colony-forming assays (Figure 6a,b and 5c-rightA monotherapy, constant with colony-forming assays (Figure 6a,b and 5c-right). However, importantly, Abl/Arg and Akt inhibitors significantly cooperated to prevent WM3248…
Min:creatinine (uACR) and urinary albumin:protein (uAPR) ratios have been calculated.Min:creatinine (uACR) and urinary albumin:protein (uAPR) ratios have been calculated. Creatinine clearance (CrCl) was calculated using the Cockroft-Gault equation, based on…
He amounts on the infiltrated constructs has to be kept the sameHe amounts in the infiltrated constructs has to be kept the same amongst treatments and controls for each and…
Ation is most extensively utilised in treating probably the most dreadful illnessesAtion is most broadly made use of in treating one of the most dreadful diseases, including cancer and AIDS.…
Xin-Wei Qiao1, Chun-Mei Bai3, Chong-Mei Lu1, Yu Xiao4, Ding-Rong Zhong4, JieXin-Wei Qiao1, Chun-Mei Bai3, Chong-Mei Lu1, Yu Xiao4, Ding-Rong Zhong4, Jie Chen4, Yu-Pei Zhao5, Tai-Ping Zhang5, Tian-Tian Song1, He-Li Gao3,…
Essed that of EXP9, XTH31, respectively. Having said that, the transcriptional regulation impactEssed that of EXP9, XTH31, respectively. Nevertheless, the transcriptional regulation effect of NF-YCs PRDX1 Protein Biological Activity around…
Asizes the will need to develop distinct scoring systems for LAIR1 Protein web fibrosis inAsizes the require to create distinct scoring systems for fibrosis in chronic viral hepatitis and NAFLD…
Ermined the IgG1 and IgG2c subtype levels in zE-specific IgGsErmined the IgG1 and IgG2c subtype levels in zE-specific IgGs from mouse sera. In place of an anti-mouse total IgG antibody,…
Ber 18,13 /In Vitro Generation of CD276/B7-H3, Human (Biotinylated, HEK293, His-Avi) Functional Beta-Like CellsFig 4. Study of insulinBer 18,13 /In Vitro Generation of Functional Beta-Like CellsFig 4. Study of insulin…
Tions. Puromycin having a final concentration of 1 g/mL was addedTions. Puromycin with a final concentration of 1 g/mL was added to screen the transfected cells. After 24-h selection, about…
Ased (by activation and aggregation) straight to the web site of injury.Ased (by activation and aggregation) directly for the site of injury.2,four,12,16,17,29 Debate continues about the following: timing, site, content…
Asizes the will need to develop distinct scoring systems for fibrosis inAsizes the have to have to develop distinct scoring systems for fibrosis in chronic viral hepatitis and NAFLD .…
S effects around the proportion of splenic CD4+ T cells expressingS effects on the proportion of splenic CD4+ T cells expressing TFH markers. Effects of PR deficiency on splenic expression…
He initially study to show that a single intra-articular injection of any GluR antagonist alleviates cartilage and bone destruction in arthritis. A single intra-articular injection of combined iGluR antagonists didn't…
Ethylation in MDA-MB-231 Cells Changes in DNA methylation by MBD-enriched DNA from MDA-MB-231 cells was analyzed just after 48 hour CQ treatment. Substantial variations have been observed in the number…
Ting enzyme; RCN, reconstituted; RS, radical SAM; SAM, S-adenosyl-L-methionine; SDS-PAGE, sodiumTing enzyme; RCN, reconstituted; RS, radical SAM; SAM, S-adenosyl-L-methionine; SDS-PAGE, sodium dodecylsulfate-polyacrylamide gel electrophoresis; SeC, selenocysteine; SeCys, selenocysteine; SI, supplementary…
Fications are supplied GM-CSF Protein Storage & Stability inside the supplement (S1, S2 Texts). Distinct kindsFications are offered within the supplement (S1, S2 Texts). Distinctive sorts of human atrial tissue…
E usually distributed. PTH was log-transformed given the skewed distribution. We then applied restricted cubic splines to model the association involving ACR and PCR with each outcome, adjusting for eGFR,…
Has been shown to become a substrate for both MCTs and SMCTs .NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptMonocarboxylate TransportersThe presence of CXCL16 Protein Storage & Stability proton…
S had been euthanized 4 h following reperfusion. Blood samples have been quickly collected in the heart and centrifuged to acquire plasma. H2S concentrations inside the plasma have been ZBP1…
Itish microbiologist, noted that "pure" cultures of bacteria could be relatedItish microbiologist, noted that "pure" cultures of bacteria can be associated using a filter-passing transparent material which may possibly entirely…
Ionizing radiation (IR) at 48 h post transfection. The -Myc antibody wasIonizing radiation (IR) at 48 h post transfection. The -Myc antibody was applied to perform immunoaffinity purification of hMSH4…
Espect for the quantity and position of GAG molecules attached, that are important for association with other proteins. Of note is that the V0 and V1 isoforms are reported to…
D right here (Table 1). Our findings imply that a combination of hydrophobic/aromatic interactions with electrostatic and hydrogen bonds is necessary for sequestering b2m fibrillar aggregates by these smaller molecules.…
Care, National Institute of Mental Overall health, New River Pharmaceuticals Inc., Otsuka America Pharmaceutical, Inc., Shire, and Sigma-Tau Pharmaceuticals Inc. Dr. McBurnett can also be a consultant for Eli Lilly…
Diography was unable to detect left ventricular systolic or diastolic dysfunctionDiography was unable to detect left ventricular systolic or diastolic dysfunction in diabetic sufferers because the early stages of DCM…
Characterized this aspect from the reaction. A similar experiment carried outCharacterized this aspect in the reaction. A similar experiment carried out with AtsB (150 M), SAM (1 mM), Kp18Ser (1…
Of carbohydrates over other power sources, in dietary restriction fat metabolism is elevated . This boost inside the use of fatty acids is paralleled by an increase in FADH2 use…
Iltrating leukocytes, ST syncytiotrophoblasts, VC vascular cells, VF villous fibroblasts, VM villous macrophages.Phillips et al. BMC Pregnancy and Childbirth 2014, 14:241 biomedcentral/1471-2393/14/Page 9 ofFigure 5 Immunohistochemical localisation of PG pathway…
Indicate that STAT3, activated by IL-6 created by mesenchymal stromal cells right after injury, promotes regeneration and multiciliogenesis via inhibition in the Notch pathway and direct regulation of genes, for…
Principal antibody was excluded, the extent of colocalization among CPA, CPBPrincipal antibody was excluded, the extent of colocalization between CPA, CPB, or mannosidaseYFP with actin was significant (P , 0.01).…
Ors around the expression of mucE in vivo. Unique cell wallOrs on the expression of mucE in vivo. Distinct cell wall stress agents have been tested for the induction of…
Ethoxycarbonylmethyl-modified (mcm5s2), or unthiolated, methoxycarbonylmethyl-modified (mcm5) tRNA CD45 Protein Formulation uridines (Figure S1C). We grew cells beneath many nutrient situations such as rich (YP), or synthetic (S), minimal defined medium…
Rated, blocked with three skim milk in phosphate-buffered saline for 120 min, then exposed to main antibodies for rat Col 1 (2 /mL), Lam (20 /mL), FN1 (20 /mL) or…
E degree of malnutrition based mostly on modifications in bodyweight and dietary consumption, the presence of GI signs and symptoms (nausea/vomiting/diarrhea), patient's practical capacity, also like a physical evaluation of…
Nsive eating due to significantly less hypoglycemia, increased energy expenditure, and higherNsive eating as a consequence of much less hypoglycemia, increased power expenditure, and larger insulin levels in the liver…
And depletion of ATP.Anti-Cancer Impact of Phenformin and OxamateFigure eight. EffectsAnd depletion of ATP.Anti-Cancer Effect of Phenformin and OxamateFigure eight. Effects of phenformin and oxamate on tumors in vivo. (A)…
Failure in the pathobiology of Alzheimer's disease: new approach to therapy," CNS and Neurological Problems Drug Targets, vol. 12, no. six, pp. 870?81, 2013. E. Corsini, V. Galbiati, D. Nikitovic,…
To EPA and DHA . While ALA is usually converted to EPA and DHA, the all round efficiency is low with conversion ranging from 0.01 to 8 in males or…
Ll ell adhesion was established, the PAN-MTs appeared as a separate network from the centrosomal MTs in the apicobasal view (Figs. 1 A and S1 A and Video 1). In…
Terizing the corresponding proteins. We located that the behavior from theTerizing the corresponding proteins. We found that the behavior of the resulting variants might be grouped into 3 categories: these…
Membered ring (B), a pyrrole ring (C) along with a seven-membered ringMembered ring (B), a pyrrole ring (C) along with a seven-membered ring (D). The five-membered rings A and E…
Ements was obtained for every M-mode parameter on 3 consecutive cardiac cycles on the very same frame. Left ventricular (LV) diameters, LVFWTable two. Nutrient composition of the diets utilised inside…
R IV exposure to C60 despite minimal Caspase-3/CASP3 Protein manufacturer Pulmonary inflammation and tiny evidence that C60 is cytotoxic in vitro. Novel to our initial predictions, administration of IV C60…
Mics 2013; 14:four. 39 Hosui A, Kimura A, Yamaji D et al. Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-b and STAT3 activation. J Exp Med…
It NF-kB gene binding activity in microglia immediately after Adiponectin/Acrp30 Protein supplier stimulation with LPSIt NF-kB gene binding activity in microglia just after stimulation with LPS . We show here…
Ors on the expression of mucE in vivo. Diverse cell wallOrs around the expression of mucE in vivo. Distinctive cell wall pressure agents have been B2M/Beta-2-microglobulin Protein medchemexpress tested for…
Nfounds, such as BMI, age, education level, comorbidities, cancer stage, time considering the fact that therapy, relationships status, statin use, tamoxifin/ aromatase inhibitor use, and antidepressant use. CDCP1 Protein Molecular…
The films, matched properly with LUMO and HOMO energies of your elements of lively layers, could effectively select electrons and block holes, leading to a rise in JSC of PSCs…
Ed bacterial replication and reduces fly life expectancy in infected adultsvspaceEd bacterial replication and reduces fly life expectancy in infected FGFR-3 Protein MedChemExpress adultsvspace2pt In mammalian cells, autophagy can also…
Mited to alternans. Oscillations FGF-2, Mouse (154a.a) exhibited the reverse with the rate dependenceMited to alternans. Oscillations exhibited the reverse from the price dependence observed in models making use of…
That constitutively activated STAT1 signaling is implicated in epithelial cancer invasion and in aggressive tumors, with emerging proof that improved STAT1 signaling can cause upregulation of genes that market resistance…
Al. and further demonstrate that enhanced SERCA2a activity suppresses triggered activities by breaking up cell-wide SCWs.Circ Res. Author manuscript; offered in PMC 2014 August 16.NIH-PA Author Manuscript NIH-PA Author Manuscript…
E benefits (Fig. 4) showed that the magnitude of antibody response was time dependent together with the PENK, Human (HEK293, His) rVCG-Pmp18D CD59 Protein MedChemExpress vaccine showing an immunogenic advantage.…
Nsive consuming as a consequence of significantly less hypoglycemia, improved power expenditure, and largerNsive eating resulting from significantly less hypoglycemia, increased power expenditure, and larger insulin levels inside the liver…
Then tagged with IRDye 680 Conjugated IgG (Li-cor, Biosciences) at room temperatureThen tagged with IRDye 680 Conjugated IgG (Li-cor, Biosciences) at space temperature for 1 h. As well as the…
Ation in the CD45 phosphatase. Boosting reduction capacity in vitro enhances RA T cell function, CD45 phosphatase activity and decreases Lck phosphorylation Incubation with N-acetyl cysteine (NAC) (100 lM) for…
R Applied Microbiology, Microbial Biotechnology, 7, 5?R. K. Kulis-Horn, M. Persicke and J. Kalinowski catalysed by exactly the same enzyme to stop the decomposition with the unstable L-histidinal intermediate (G…
Action possible recordings. B, mean ?SEM AP duration at 90 of repolarization (APD90 ) below each condition. n = variety of experiments, P 0.01 and P 0.001.C2013 The Authors. The…
And dominant-negative VCPE305QE578Q had been transfected into HeLa cells stablyAnd dominant-negative VCPE305QE578Q had been transfected into HeLa cells stably expressing G64D-V5. Twenty-four hours later, the cells had been lysed after…
Rent (p,0.05). doi:ten.1371/journal.pone.0085323.gBut at weeks 2 and three, the ratio of Firmicutes to Bacteroidetes decreased considerably each in low and high Cd treatment options when compared with control. Probiotics like…
Nd Maria Cornellier was the study dietitian. This study was supported by a grant from the Ronald P. and Joan M. Nordgren Cancer Analysis Fund, NIH grant RO1 CA120381, and…
Th conditionsPlasmids and Bax Inhibitor Storage & Stability stains utilised in this study are listed in Table two. Escherichia. coli DH5 and Top10 had been utilized for plasmid construction and…
Ure or conduction block occurred inside the tissue (Fig. 2A,PLOSUre or conduction block occurred in the tissue (Fig. 2A,PLOS Computational Biology | ploscompbiol.orgwhite spaces). These final results recommend that altered…
Membered ring (B), a pyrrole ring (C) in addition to a seven-membered ringMembered ring (B), a pyrrole ring (C) in addition to a seven-membered ring (D). The five-membered rings A…
D SiO2, 3 g, 100 Dynamin custom synthesis CH2Cl2, 1 MeOH/ CH2Cl2) to afford coupled pyrimidine 32 as a pale white powder (0.065 g, 78 ); TLC Rf = 0.2…
Ing as an antagonist of your Wnt pathway . Nonetheless, JW74 remedy didn't lead to reduced SOX2 expression in U2OS cells. Thus, mechanisms involving SOX2 don't look accountable for the…
Ative serum C-peptide 0.three nmol/l and BMI 18?0 kg/m2 . Eligible participants have been randomized in two parallel cohorts (Figure S2) to acquire SC once-daily doses of either 0.four (cohort…
Re proper, basal ALK5 Inhibitor Compound insulin dose was adjusted to retain a fastingRe appropriate, basal insulin dose was adjusted to preserve a fasting glucose degree of ,7 mmolL. Standard…
Ors around the expression of mucE in vivo. Various cell wallOrs around the expression of mucE in vivo. Various cell wall Bak supplier stress agents had been tested for the…
Mpared to CD26-knockdown or versican-knockdown clones. Conclusions: Our data indicate that CD26 includes a key part in cell adhesion and invasion, and potentially in tumorigenesis of LIM Kinase (LIMK) review…
Se in IgG immune complex-induced secretion of theses cytokines and chemokines from neutrophils (TNF- and KC at all time points, Fig. 7A and C; IL-6 and MIP-1 at four? h…
Ic target because of its value in a range of essential biological processes. The cholinergic method has been shown previously to be a major modulator of parasite motility. Within this…
Respondence to: Xavier Wittebole; E-mail: xavier.witteboleuclouvain.be Submitted: 06272013; Revised: 07302013; AcceptedRespondence to: Xavier Wittebole; E mail: xavier.witteboleuclouvain.be Submitted: 06272013; Revised: 07302013; Accepted: 07312013 http:dx.doi.org10.4161viru.considering the fact that its inception as…
Ors on the expression of mucE in vivo. Adenosine A2A receptor (A2AR) Compound Various cell wallOrs around the expression of mucE in vivo. Unique cell wall tension agents had been…
Ch) was performed using a industrial array (Dharmacon Inc of Thermo Scientific). Relative Intensity data for eight samples was subjected to statistical filtering, maintaining miR probes with P 0.05 in…
Tive Neuroscience and Endocrinology, College of Clinical Sciences, University of Bristol, Dorothy Hodgkin Constructing, Bristol BS1 3NY, UK 3 St Michael's Hospital, Southwell Street, Bristol BS2 8EG, UK Complete list…
Or cervicovaginal oncological colpocytology (carried out inside the previous 12 months) and people who presented a personalhistory of cardiovascular disease or venous or arterial thromboembolism. Girls presenting dyslipidemia, diabetes mellitus,…
Ransferred to Flvox via an auxiliary cluster. These studies herein, andRansferred to Flvox by means of an auxiliary cluster. These research herein, and future studies, will supply a lot necessary…
Mited to alternans. oscillations exhibited the reverse from the price dependenceMited to alternans. Oscillations exhibited the reverse in the rate dependence observed in models making use of the original RyR…
Ocols. Proteins have been separated on 4-15 gradient sodium dodecyl sulfate (SDS)-polyacrylamide gels and transferred to Immobilon-P membranes (Millipore, Billerica, MA). The following principal antibodies were applied: Akt, PARP, survivin…
Cells. The aim of the present study was to investigate the inhibitory effects of telomerase activity by CAUE inside a NALM-6 cell culture system. CAUE was shown to preferentially damage…
Ght be explained by the possibility of drafting inside the cycling split. In international long-distance triathlon, drafting is prohibited in contrast to shortdistance triathlons in the ITU Globe Triathlon Series.…
Nsive eating on account of less hypoglycemia, improved energy expenditure, and greaterNsive consuming resulting from much less hypoglycemia, improved power expenditure, and larger insulin levels in the liver compared with…
Nd 5-HT (F1,29 = 16, p 0.05) have been decreased when 5-HIAA was elevated (FNd 5-HT (F1,29 = 16, p 0.05) were decreased when 5-HIAA was elevated (F1,29 = 119,…
Defined. In this study, platelet activation was analyzed by evaluating the activation markers of platelets, including Pselectin and GPIIb/IIIa. Each of these integrins are expressed only on the surface of…
De B) loaded nitrocellular membranes (NCM) were incubated with cell cultureDe B) loaded nitrocellular membranes (NCM) were incubated with cell culture supernatants collected from HR-Hutat2-transduced HTB-11 (HTB-Hutat2), U937 (U937-Hutat2), or…
We report that resistance to mHgIA in DBA/2J mice is related with the Caspase 4 Inhibitor Biological Activity absence of a nearby inflammatory response at the internet site of HgCl2…
Duz E, Celik JB, Senaran H. Spinal anaesthesia for orthopaedic surgeryDuz E, Celik JB, Senaran H. Spinal anaesthesia for orthopaedic surgery in youngsters with cerebral palsy: Evaluation of 36 individuals.…
And dominant-negative VCPE305QE578Q were transfected into HeLa cells stablyAnd dominant-negative VCPE305QE578Q were transfected into HeLa cells stably expressing G64D-V5. Twenty-four hours later, the cells were lysed and after that subjected…
A challenge, with ejaculates demonstratinggreat variation and a high proportion (. 85 ) exhibiting lowered semen high quality . This higher incidence of variability in ejaculate high quality is just…
By an increased fetal demand. Despite these caveats, the accessible information from IUGR in humans is generally agreement together with the placental nutrient sensing model for regulation of placental transporters.…
E similarly negative. The mutation analysis for the colonystimulating factor3 recep tor gene (CSF3R) was performed by bidirectional sequenc ing method. The mutation hot spots exon 14 and exon 17…
He concentration of Flvdoes not modify considerably for the duration of catalysis. When theHe concentration of Flvdoes not alter substantially for the duration of catalysis. When the ejected electron had…
Proved for treating cancers and quite a few a lot more show related guarantee (GarrawayProved for treating cancers and lots of additional show similar guarantee (Garraway and Lander, 2013; Suvet…
Ting Data Fig S8A). Most importantly, increased expression of CCL2/CCR2 and EMT markers was observed in mouse prostates soon after castration (Supporting3 Figure four.ARsilencing induced CCL2/CCR2/STAT3 signalling controls EMT. A.…
Ifying as consanguine and with one nicely kid. A prolonged PT MAO-B Inhibitor MedChemExpress responded to parenteral vitamin K; serum vitamins A, D, and E had been low and serum…
N M anti-HAV antibody; IgG anti-HAV, immunoglobulin G anti-HAV antibody; SD, regular deviation; NS, not important.?2014 John Wiley Sons Ltd, Immunology, 143, 578?Bilirubin and cytokines in HAV infection(a) 85 IL-6…
Nsive eating as a result of significantly less hypoglycemia, enhanced power expenditure, and largerNsive eating because of less hypoglycemia, improved power expenditure, and larger insulin levels inside the liver compared…
Nd 5-HT (F1,29 = 16, p 0.05) were decreased whilst 5-HIAA was elevated (FNd 5-HT (F1,29 = 16, p 0.05) have been decreased even though 5-HIAA was elevated (F1,29 =…
N=Embase n=223 Duplicates, n=Total publications for overview n=Excluded, n=201 Not human, n=10 Not low BMD or osteoporosis, n=8 Not raloxifene, n=17 No relevant outcomes, n=19 Case reports, n=9 Narrative reviews,…
Nd in the periphery . This may explain why CXCL10 is only very first detectable three?1 weeks immediately after HCV RNA within the plasma of acutely infected HCV individuals .…
Nd a shape-based original docking. The appropriate docking poses had been then optionally minimizedEvidence-Based Complementary and Substitute Medicine0.25 0.twenty 0.15 0.ten 0.05 0.00 0.30 0.25 0.twenty 0.15 0.10 0.05 0.00…
Ors around the expression of mucE in vivo. Different cell wallOrs around the expression of mucE in vivo. Various cell wall stress agents have been tested for the induction of…
Ture more than phenotypic markers, when the key biological concentrate rests on traits on the mixture structure over multimers and also the classification of cells based on subtypes in multimer…
Ts cytoplasmic receptor domain . Signaling from MAVS or TRIF activates numerous transcription aspects such as IRF-3 (IFN regulatory aspect three), IRF-7, NF--" (nuclear factor--" ) and AP-1 (activator protein…
C). Selective deprotection on the two,5-dimethlypyrrole was achieved in superior yields (Table four). Product purification was also easier because of a significantly non-polar product in comparison to the aliphatic amine…
When dietary carbohydrate intake is α adrenergic receptor Formulation restricted seems to ALK5 Inhibitor manufacturer happen upstream ofWhen dietary carbohydrate intake is restricted appears to happen upstream of PGC-1a and…
Replete state. Nevertheless, it might be doable to use carbohydrate restrictionReplete state. Nevertheless, it could possibly be probable to utilize carbohydrate CDK4 Molecular Weight restriction to augment mitochondrial adaptations to…
Patient for 20 CYP26 custom synthesis months without having big complications. Soon after 1 month of in-house remedy applying every day CLZ 500 mg and clomipramine 75 mg (to treat…
Tion within the GSH/GSSG ratio induced by HFD (Figure 3C) was prevented in HFD mice handled with apocynin (Figure 3C). These effects show a chronic pro-oxidant intracellular atmosphere in insulin-resistant…
Ined from mice treated with saline, morphine, fentanyl or oxycodone when a day for 14 consecutive days from 7 days soon after sham operation or nerve ligation (Fig. three). The…
Sleep symptoms are non-specific and could reflect a number of underlyingSleep symptoms are non-specific and could reflect many different underlying causes, such as specific sleep issues for instance insomnia or…
Ors around the expression of mucE in vivo. Different cell wallOrs around the expression of mucE in vivo. Distinct cell wall tension agents had been tested for the induction of…
Nd these responses, but not p-ERK, have been additional augmented in NlrcNd these responses, but not p-ERK, had been further augmented in Nlrc3-- cells, supporting the model that NLRC3 regulates…
L deficits, or any drug intake. Household history of alcoholism, but not hypertension was noted in his father and brother. On admission, important parameters showed marginal alcohol withdrawal sympathetic activity…
The web site occupied by sulfate within the native FIBCD1 structure. Mainly becauseThe web page occupied by sulfate in the native FIBCD1 structure. Since FIBCD1 recognizes GlcNAc and GalNAc equally…
Membered ring (B), a pyrrole ring (C) plus a seven-membered ringMembered ring (B), a pyrrole ring (C) and a seven-membered ring (D). The five-membered rings A and E exhibit envelope…
Iology two (2014) 447?Fig. six. CB3 and CB4 inhibit caspase 3 and PARP dissociation in SH-SY5Y cells. (A) SH-SY5Y cells were treated for 24 h with or with no CB3…
N et al.PageLow molecular weight compounds diffuse freely into and out of hydrogels; having said that, the diffusion of bigger species is retarded by the gel, and, above a particular…
O three treatment groups (17 to 26 animals per group): automobile alone, estradiol, and estradiol plus metformin. Metformin (300 mg/kg body weight/ day in 1 methyl-cellulose remedy) was administrated by…
Values of 19 and 12 M, emerging as the most potent antagonists ofValues of 19 and 12 M, emerging because the most potent antagonists with the series. In specific, compound…
Vestigating Notch signaling expression in microglia soon after LPS stimulation . Therefore, weVestigating Notch signaling expression in microglia FGFR1 Formulation following LPS stimulation . Therefore, we felt it proper to…
Ed pancreatic cancer individuals than for patients with other solid cancers. They commented that these benefits recommend that immunity in sophisticated pancreatic cancer is additional depressedthan in other epithelial cancers.…
Mg/ml) for 3 h at 37 1C. Right after derivation, iPSCs had been initially grown on a MEF feeder layer in human embryonic stem cell (ES) medium, that's, knockout DMEM…
Ound sufficient to solubilize 85 of a1b3 GABAARs,17 however the presenceTable II. Yields and Particular Routines of Receptors Expressed on 15-cm PlatesaSpecific action (pmol/mg) (N) LAG 1b3g2?C) three?D4 GABAAR FLAG…
Along with a full monograph with the journal La M icine coveredAlong with a full monograph on the journal La M icine covered phage applications in human disease.110 It described…
N of different sets of anthocyanins. As an example, the anthocyanin patterns of seedlings grown at pH three.three or in media lacking phosphate are extremely related and characterized by relatively…
Nducted on schizophrenia using postmortem brains, but the sample sizes ofNducted on schizophrenia using postmortem brains, however the sample sizes of those research had been reasonably tiny (35 individuals with…
Making use of effector CD4 T cells ready from cLNs to examine regardless of whetherMaking use of effector CD4 T cells prepared from cLNs to examine no matter whether these…
O be efficient endotoxin releasing antibiotics and each the antibiotics considerably released higher amount of endotoxin (p,0.001) (Fig.1 ). Around the basis of benefits from in vitro endotoxin release assay,…
As both a trigger in addition to a target for IL-6 (Zhang etAs both a trigger in addition to a target for IL-6 (Zhang et al., 2013; Maekawa et al.,…
As blotted with all the acceptable antibodies. Anti-PARP, -p-EGFR, -EGFR, -p-STAT3, -STATAs blotted with all the appropriate antibodies. Anti-PARP, -p-EGFR, -EGFR, -p-STAT3, -STAT3, -p-JAK1, -p-JAK2, -p-AKT, and -AKT antibodies had…
A challenge, with ejaculates demonstratinggreat Glucosidase Accession variation and also a high proportion (. 85 ) exhibiting lowered semen top quality . This high incidence of variability in ejaculate high-quality…
Ced increase in telomerase activity in irradiated cells, ruling out a part in the PI3K/AKT pathway inside the radiation-induced upregulation of telomerase activity in our model. Discussion The PI3-kinase/AKT pathway…
An extended macrophage presence. It may be as well simplistic to assume that extending the period more than which macrophages persist in the area of an infarct would supply good…
An muscle FBPase with the loop in its engaged state wasAn muscle FBPase with all the loop in its engaged state was constructed on the basis of 1CNQ as described…
Eins accumulation in renal cells by stimulating the CCR9 list expression of proteaseEins accumulation in renal cells by stimulating the expression of protease inhibitors, including plasminogen activator inhibitor-1 (PAI-1)15,16. PAI-1,…
Had been enhanced by MPP and rotenone in these cells, which couldHad been enhanced by MPP and rotenone in these cells, which might be dosedependently attenuated by SNJ-1945 pre-treatment (Fig…
N prior to the scan (P , 0.01 for each and every item), indicating that appetiteN prior to the scan (P , 0.01 for every item), indicating that appetite increased…
Is by tube formation assay by means of generating angiogenic elements, which includes VEGF and bFGF (9). In the present study, we located that the tube-forming capability of lal-/- ECs…
Ion (32.21 ?six.5 ), methanol extract (29.32 ?4.five ) and water fraction (18.06 ?four.6 ). In summary, the crude and fractionated extracts of rhizomes of Alpinia pahangensis showed varying PDE6…
Ted by subtracting the release obtained throughout a 5-min depolarization at 200 nM free in the release at 1.33 mM CaCl2. Control release was Ca2 -dependent release induced by KCl…
Of genes,18 an thought already hypothesized by Muller in 1922.19 The phenomenonOf genes,18 an idea currently hypothesized by Muller in 1922.19 The phenomenon of lysogeny, or the fact that bacteriophages…
Eins accumulation in renal cells by stimulating the expression of proteaseEins accumulation in renal cells by stimulating the expression of protease inhibitors, including plasminogen activator inhibitor-1 (PAI-1)15,16. PAI-1, a important…
Ght for age z-scores have been considerably reduce than 0 (p 0.001) and stunting was prevalent (42.9 ). Zinc deficiency was extremely prevalent in Cambodia (92.eight ), whereas zinc deficiency…
O respond to TAM. Chrisholm et al. also showed cytotoxic effects of EGCG alone in one more ER-negative breast cancer cell line, Hs578T as well as a synergistic cytotoxic effect…
Study of your drug product. Therefore towards the greatest of our present know-how, no stability-indicating HPLC process has been reported for the estimation of all seven FP Inhibitor Species impurities…
Ers to identify individuals with TKI-resistant CML whose illness will respondErs to recognize sufferers with TKI-resistant CML whose illness will respond to therapies that target ALT NHEJ. Our analysis of…
Hem. Author manuscript; offered in PMC 2014 November 01.Chen et al.PageToHem. Author manuscript; out there in PMC 2014 November 01.Chen et al.PageTo recognize the most effective oligomer backbone for this…
Layers (Fig. 6B arrow, major right panel). This longitudinal fissure observedLayers (Fig. 6B arrow, major correct panel). This longitudinal fissure observed in isolated AM may possibly represent the split that…
Ts in cancers (18). A nanoparticle-encapsulating EGCG has also been made for oral administration in mice with human prostate cancer (50, 51). Our study highlights that the influence and specificity…
Sis of rat fibroblasts just after two and 24 h of exposure to hydrogel leachables. As noticed in Figure 9A, in the 2 h time point, no distinction was seen…
Inib was given orally day-to-day with cetuximab offered intravenously on daysInib was offered orally daily with cetuximab given intravenously on days 1, eight, 15, and 22 of a 28 day…
Icrobiologists of IndiaAbstract Muscodor albus MOW12, an endophytic fungus isolated fromIcrobiologists of IndiaAbstract Muscodor albus MOW12, an endophytic fungus isolated from Piper nigrum in Mawlong, Meghalaya, India, resembles some cultural…
E recent GTX680 card (1536 cores, 2G memory) this reduces further to about 520 s. The application will likely be obtainable in the publication net web site.NIH-PA Author Manuscript NIH-PA…
Tre, St, Petersburg, Russia; 12Ruijin Hospital, Shanghai, China; 13First Affiliated Hospital, Zhejiang University College of Medicine, mTORC2 Activator Purity & Documentation Hangzhou, Zheinicas da Universidade Federal do Paran, a jiang,…
Cer Center under IRB approval. Millennium Inc. provided bortezomib and a fewCer Center below IRB approval. Millennium Inc. provided bortezomib and a few support for conduct from the trial. Interferon…