Product Name :
JNJ-54166060
Description:
JNJ-54166060 is a potent and selective P2X7 receptor antagonist, with IC50s of 4/115/72 nM for human/rat/mouse P2X7 receptor, respectively.
CAS:
1627900-41-7
Molecular Weight:
438.81
Formula:
C20H15ClF4N4O
Chemical Name:
2-[(4R)-5-[2-chloro-3-(trifluoromethyl)benzoyl]-4-methyl-1H, 4H, 5H, 6H, 7H-imidazo[4, 5-c]pyridin-1-yl]-5-fluoropyridine
Smiles :
C[C@@H]1C2N=CN(C3=CC=C(F)C=N3)C=2CCN1C(=O)C1=CC=CC(=C1Cl)C(F)(F)F
InChiKey:
PLIXFSPGDVKMDM-LLVKDONJSA-N
InChi :
InChI=1S/C20H15ClF4N4O/c1-11-18-15(29(10-27-18)16-6-5-12(22)9-26-16)7-8-28(11)19(30)13-3-2-4-14(17(13)21)20(23,24)25/h2-6,9-11H,7-8H2,1H3/t11-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.Picaridin Autophagy
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
JNJ-54166060 is a potent and selective P2X7 receptor antagonist, with IC50s of 4/115/72 nM for human/rat/mouse P2X7 receptor, respectively.|Product information|CAS Number: 1627900-41-7|Molecular Weight: 438.81|Formula: C20H15ClF4N4O|Chemical Name: 2-[(4R)-5-[2-chloro-3-(trifluoromethyl)benzoyl]-4-methyl-1H, 4H, 5H, 6H, 7H-imidazo[4, 5-c]pyridin-1-yl]-5-fluoropyridine|Smiles: C[C@@H]1C2N=CN(C3=CC=C(F)C=N3)C=2CCN1C(=O)C1=CC=CC(=C1Cl)C(F)(F)F|InChiKey: PLIXFSPGDVKMDM-LLVKDONJSA-N|InChi: InChI=1S/C20H15ClF4N4O/c1-11-18-15(29(10-27-18)16-6-5-12(22)9-26-16)7-8-28(11)19(30)13-3-2-4-14(17(13)21)20(23,24)25/h2-6,9-11H,7-8H2,1H3/t11-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Desipramine References |Shelf Life: ≥12 months if stored properly.PMID:33100065 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|JNJ-54166060 exhibits high oral bioavailability (rat 55%, dog >100%, monkey 54 %) and Cmax (rat 375, dog 1249, monkey 389 ng/mL) following oral administration (rat 5 and, dog 5 mg/kg, monkey 5 mg/kg). JNJ-54166060 exhibits terminal elimination half-lives (rat 1.7 and, dog 11.9 h, monkey 4.2 h) due to low-moderate clearance (30, 5.5, and 14 mL/min/kg respectively) following intravenous administration (rat 1.0 and, dog 1.0 mg/kg, monkey 1.0 mg/kg).|Products are for research use only. Not for human use.|