Product Name :
Lopinavir
Description:
Lopinavir is an HIV protease inhibitor used in a fixed-dose combination with Ritonavir. It is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir, under the trade names Kaletra and Aluvia. It was first approved by the FDA on 15 September 2000.
CAS:
192725-17-0
Molecular Weight:
628.80
Formula:
C37H48N4O5
Chemical Name:
(2S)-N-[(2S,4S,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
Smiles :
CC(C)[C@@H](C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)COC1=C(C)C=CC=C1C)CC1=CC=CC=C1)N1CCCNC1=O
InChiKey:
KJHKTHWMRKYKJE-SUGCFTRWSA-N
InChi :
InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Lopinavir is an HIV protease inhibitor used in a fixed-dose combination with Ritonavir. It is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir, under the trade names Kaletra and Aluvia. It was first approved by the FDA on 15 September 2000.|Product information|CAS Number: 192725-17-0|Molecular Weight: 628.80|Formula: C37H48N4O5|Synonym:|ABT-378|Aluviran|Koletra|A-157378.0|Lopinavir|ABT 378|A 157378.0|A157378.0|ABT378|Chemical Name: (2S)-N-[(2S,4S,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide|Smiles: CC(C)[C@@H](C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)COC1=C(C)C=CC=C1C)CC1=CC=CC=C1)N1CCCNC1=O|InChiKey: KJHKTHWMRKYKJE-SUGCFTRWSA-N|InChi: InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO, not in water|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Gemfibrozil} MedChemExpress|{Gemfibrozil} PPAR|{Gemfibrozil} Protocol|{Gemfibrozil} In stock|{Gemfibrozil} supplier|{Gemfibrozil} Autophagy} |Shelf Life: ≥12 months if stored properly.{{DNQX} site|{DNQX} iGluR|{DNQX} TGF-beta/Smad|{DNQX} Protocol|{DNQX} In Vivo|{DNQX} custom synthesis} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24140575 |Drug Formulation: To be determined.|HS Tariff Code: 382200|References:|Aline F, Aurélie R, Matthias C, Olivier B, Thierry B, Paule SM, Chantal C. Comparison of population pharmacokinetics based on steady-state assumption versus electronically monitored adherence to lopinavir, atazanavir, efavirenz, and etravirine: A retrospective study. Ther Drug Monit. 2016 Mar 1. [Epub ahead of print] PubMed PMID: 26937748.Raposo LM, Arruda MB, de Brindeiro RM, Nobre FF. Lopinavir Resistance Classification with Imbalanced Data Using Probabilistic Neural Networks. J Med Syst. 2016 Mar;40(3):69. doi: 10.1007/s10916-015-0428-7. Epub 2016 Jan 6. PubMed PMID: 26733278.Patel G, Shelat P, Lalwani A. Statistical modeling, optimization and characterization of solid self-nanoemulsifying drug delivery system of lopinavir using design of experiment. Drug Deliv. 2016 Feb 16:1-16. [Epub ahead of print] PubMed PMID: 26882014.Products are for research use only. Not for human use.|