Product Name :
Lasiocarpine
Description:
Lasiocarpine, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo. Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide.
CAS:
303-34-4
Molecular Weight:
411.49
Formula:
C21H33NO7
Chemical Name:
(1S,7aR)-7-({[(2R)-2,3-dihydroxy-2-[(1S)-1-methoxyethyl]-3-methylbutanoyl]oxy}methyl)-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-yl (2Z)-2-methylbut-2-enoate
Smiles :
CC(C)(O)[C@](O)([C@H](C)OC)C(=O)OCC1=CCN2CC[C@H](OC(=O)/C(/C)=C\C)[C@H]21
InChiKey:
QHOZSLCIKHUPSU-LPLKQDONSA-N
InChi :
InChI=1S/C21H33NO7/c1-7-13(2)18(23)29-16-9-11-22-10-8-15(17(16)22)12-28-19(24)21(26,14(3)27-6)20(4,5)25/h7-8,14,16-17,25-26H,9-12H2,1-6H3/b13-7-/t14-,16-,17+,21-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Lasiocarpine, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo.{{VinclozolinM2-2204} MedChemExpress|{VinclozolinM2-2204} Androgen Receptor|{VinclozolinM2-2204} TGF-beta/Smad|{VinclozolinM2-2204} Technical Information|{VinclozolinM2-2204} Formula|{VinclozolinM2-2204} supplier} Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide.|Product information|CAS Number: 303-34-4|Molecular Weight: 411.49|Formula: C21H33NO7|Chemical Name: (1S,7aR)-7-({[(2R)-2,3-dihydroxy-2-[(1S)-1-methoxyethyl]-3-methylbutanoyl]oxy}methyl)-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-yl (2Z)-2-methylbut-2-enoate|Smiles: CC(C)(O)[C@](O)([C@H](C)OC)C(=O)OCC1=CCN2CC[C@H](OC(=O)/C(/C)=C\C)[C@H]21|InChiKey: QHOZSLCIKHUPSU-LPLKQDONSA-N|InChi: InChI=1S/C21H33NO7/c1-7-13(2)18(23)29-16-9-11-22-10-8-15(17(16)22)12-28-19(24)21(26,14(3)27-6)20(4,5)25/h7-8,14,16-17,25-26H,9-12H2,1-6H3/b13-7-/t14-,16-,17+,21-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Rac1-IN-4} web|{Rac1-IN-4} Inhibitor|{Rac1-IN-4} NF-κB|{Rac1-IN-4} Biological Activity|{Rac1-IN-4} Description|{Rac1-IN-4} supplier} |Shelf Life: ≥12 months if stored properly.PMID:23937941 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, known as dehydrolasiocarpine. Dehydrolasiocarpine and other putative didehydropyrrolizidine alkaloids (the pyrrolic esters) are very reactive,they attack nucleophilic macromolecules such as DNA and proteins, eliciting severe toxicities, including liver veno-occlusive disease and tumors. Lasiocarpine is mainly metabolized in vitro through five metabolic pathways, dehydrogenation, ester bond cleavage, demethylation.|Products are for research use only. Not for human use.|