Product Name :
Chroman 1 dihydrochloride
Description:
Chroman 1 dihydrochloride is a highly potent and selective ROCK inhibitor. Chroman 1 dihydrochloride is more potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM). Chroman 1 dihydrochloride also has inhibitory activity against MRCK, with an IC50 of 150 nM.
CAS:
Molecular Weight:
509.43
Formula:
C24H30Cl2N4O4
Chemical Name:
(3S)-N-{2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl}-6-methoxy-3, 4-dihydro-2H-1-benzopyran-3-carboxamide dihydrochloride
Smiles :
Cl.Cl.COC1=CC2C[C@@H](COC=2C=C1)C(=O)NC1=CC=C(C=C1OCCN(C)C)C1=CNN=C1
InChiKey:
BZROBPNUVVJVJQ-NTEVMMBTSA-N
InChi :
InChI=1S/C24H28N4O4.2ClH/c1-28(2)8-9-31-23-12-16(19-13-25-26-14-19)4-6-21(23)27-24(29)18-10-17-11-20(30-3)5-7-22(17)32-15-18;;/h4-7,11-14,18H,8-10,15H2,1-3H3,(H,25,26)(H,27,29);2*1H/t18-;;/m0../s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Chroman 1 dihydrochloride is a highly potent and selective ROCK inhibitor. Chroman 1 dihydrochloride is more potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM). Chroman 1 dihydrochloride also has inhibitory activity against MRCK, with an IC50 of 150 nM.|Product information|Molecular Weight: 509.43|Formula: C24H30Cl2N4O4|Chemical Name: (3S)-N-{2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl}-6-methoxy-3, 4-dihydro-2H-1-benzopyran-3-carboxamide dihydrochloride|Smiles: Cl.Cl.COC1=CC2C[C@@H](COC=2C=C1)C(=O)NC1=CC=C(C=C1OCCN(C)C)C1=CNN=C1|InChiKey: BZROBPNUVVJVJQ-NTEVMMBTSA-N|InChi: InChI=1S/C24H28N4O4.2ClH/c1-28(2)8-9-31-23-12-16(19-13-25-26-14-19)4-6-21(23)27-24(29)18-10-17-11-20(30-3)5-7-22(17)32-15-18;;/h4-7,11-14,18H,8-10,15H2,1-3H3,(H,25,26)(H,27,29);2*1H/t18-;;/m0.{{Zidovudine} medchemexpress|{Zidovudine} Cell Cycle/DNA Damage|{Zidovudine} Protocol|{Zidovudine} Purity|{Zidovudine} custom synthesis|{Zidovudine} Autophagy} .{{Andecaliximab} medchemexpress|{Andecaliximab} Metabolic Enzyme/Protease|{Andecaliximab} Protocol|{Andecaliximab} In stock|{Andecaliximab} manufacturer|{Andecaliximab} Autophagy} /s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32060646 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Yu Chen, et al. A Versatile Polypharmacology Platform Promotes Cytoprotection and Viability of Human Pluripotent and Differentiated Cells. bioRxiv 815761.Yen Ting Chen, et al. Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors. Med.Chem.Commun., 2011, 2, 73-75.Products are for research use only. Not for human use.|