Product Name :
48740 RP
Description:
48740 RP (RP-55778) is a platelet-activating factor (PAF) antagonist.
CAS:
93363-11-2
Molecular Weight:
245.30
Formula:
C12H11N3OS
Chemical Name:
3-(pyridin-3-yl)-1H,3H-pyrrolo[1,2-c][1,3]thiazole-7-carboxamide
Smiles :
NC(=O)C1C=CN2C(SCC2=1)C1C=NC=CC=1
InChiKey:
ARFOASMERCHFBY-UHFFFAOYSA-N
InChi :
InChI=1S/C12H11N3OS/c13-11(16)9-3-5-15-10(9)7-17-12(15)8-2-1-4-14-6-8/h1-6,12H,7H2,(H2,13,16)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
48740 RP (RP-55778) is a platelet-activating factor (PAF) antagonist.|Product information|CAS Number: 93363-11-2|Molecular Weight: 245.30|Formula: C12H11N3OS|Synonym:|RP-55778|Chemical Name: 3-(pyridin-3-yl)-1H,3H-pyrrolo[1,2-c][1,3]thiazole-7-carboxamide|Smiles: NC(=O)C1C=CN2C(SCC2=1)C1C=NC=CC=1|InChiKey: ARFOASMERCHFBY-UHFFFAOYSA-N|InChi: InChI=1S/C12H11N3OS/c13-11(16)9-3-5-15-10(9)7-17-12(15)8-2-1-4-14-6-8/h1-6,12H,7H2,(H2,13,16)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.Sonelokimab Immunology/Inflammation |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|48740 RP (RP-55778) is a platelet-activating factor (PAF) antagonist.β-Carotene Cancer In animals treated with 48740 RP only, the number of platelets is increased at a time corresponding to 2 and 4 h after the exposure to lipopolysaccharide (LPS) and the number of eosinophils is also slightly increased.PMID:33299235 Treatment with 48740 RP in combination with the LPS exposure does not influence the increase in neutrophils seen 2 and 4 h after exposure. At 24 h the increase in the number of neutrophils is about half that in control animals. No effects are found on the LPS-induced increase in number of platelets. In animals pretreated with 48740 RP, there is a significant reduction in capillary permeability.|References:|Rylander R, et al. Modulation of pulmonary inflammation after endotoxin inhalation with a platelet-activating factor antagonist (48740 RP). Int Arch Allergy Appl Immunol. 1988;86(3):303-7.Products are for research use only. Not for human use.|