Product Name :
Thyrotropin-Releasing Hormone (TRH), Free Acid
Description:
Thyrotropin-Releasing Hormone (TRH), Free Acid (TRH-OH) is a physiological metabolite of Thyrotropin-Releasing Hormone.
CAS:
24769-58-2
Molecular Weight:
363.37
Formula:
C16H21N5O5
Chemical Name:
(2S)-1-[(2S)-3-(1H-imidazol-5-yl)-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}propanoyl]pyrrolidine-2-carboxylic acid
Smiles :
OC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1=CN=CN1)NC(=O)[C@@H]1CCC(=O)N1
InChiKey:
ITYONPBTNRIEBA-SRVKXCTJSA-N
InChi :
InChI=1S/C16H21N5O5/c22-13-4-3-10(19-13)14(23)20-11(6-9-7-17-8-18-9)15(24)21-5-1-2-12(21)16(25)26/h7-8,10-12H,1-6H2,(H,17,18)(H,19,22)(H,20,23)(H,25,26)/t10-,11-,12-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Thyrotropin-Releasing Hormone (TRH), Free Acid (TRH-OH) is a physiological metabolite of Thyrotropin-Releasing Hormone.|Product information|CAS Number: 24769-58-2|Molecular Weight: 363.37|Formula: C16H21N5O5|Chemical Name: (2S)-1-[(2S)-3-(1H-imidazol-5-yl)-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}propanoyl]pyrrolidine-2-carboxylic acid|Smiles: OC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1=CN=CN1)NC(=O)[C@@H]1CCC(=O)N1|InChiKey: ITYONPBTNRIEBA-SRVKXCTJSA-N|InChi: InChI=1S/C16H21N5O5/c22-13-4-3-10(19-13)14(23)20-11(6-9-7-17-8-18-9)15(24)21-5-1-2-12(21)16(25)26/h7-8,10-12H,1-6H2,(H,17,18)(H,19,22)(H,20,23)(H,25,26)/t10-,11-,12-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Simvastatin} web|{Simvastatin} Apoptosis|{Simvastatin} Purity & Documentation|{Simvastatin} Formula|{Simvastatin} manufacturer|{Simvastatin} Autophagy} |Shelf Life: ≥12 months if stored properly.{{STAT3-IN-20} web|{STAT3-IN-20} JAK/STAT Signaling|{STAT3-IN-20} Immunology/Inflammation|{STAT3-IN-20} Purity & Documentation|{STAT3-IN-20} In stock|{STAT3-IN-20} custom synthesis} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|TRH degradation products have been shown to be associated with a number of endocrine- and central nervous system-related biological functions.PMID:32310465 TRH (pGlu-His-Pro-NH2) can be enzymatically degraded in plasma and brain tissue to yield TRH-OH. TRH and hGHRH stimulate the release of [3H]GH into the culture medium to 435 and 464%, respectively, when compared to the control, but TRH-OH has no effect. TRH-OH, produced after cleavage of the C-terminal amide group by a specific proline endopeptidase, is one of the most stable derivatives of TRH and is found at high levels in numerous brain regions. TRH-OH inhibits Na+ channel activity in mammalian septal neurons. In about 60% of the cells tested, TRH-OH at concentrations between 0.01 and 2.5 μM produces a dose-dependent reversible attenuation of Na+ currents. With 2 μM TRH-OH, peak Na+ current amplitude is reduced by 20-50%.|Products are for research use only. Not for human use.|