L deficits, or any drug intake. Household history of alcoholism, but not hypertension was noted in his father and brother. On admission, important parameters showed marginal alcohol withdrawal sympathetic activity with pulse rate of 96 beats/min and BP of 140/90 mm of Hg. His general physical plus the CCR3 Antagonist manufacturer systemic examination revealed no other abnormal findings, except for fine tremors of both hands and mild hepatomegaly. Patient had preoccupations with alcohol, anxious mood with preserved cognitions, and grade4 insight. Following alcohol detoxification, his BP had stabilized to 120/84 mm of Hg on day8 of admission. Electrocardiograph revealed no abnormalities. Hematological and biochemical investigations for instance complete blood count, blood glucose (105 mg/dl), blood urea (25 mg/dl), and serum creatinine (1.0 mg/dl) had been inside typical limits. Liver function tests have been standard except for elevated liver enzymes (gammaglutamyl transferase 96 units/L; serum glutamic oxaloacetic transaminase 120 units/L; serum glutamic pyruvic transaminase 56 units/L). His ultrasound abdomen showed mildly enlarged liver with grade2 fatty infiltration. Considering frequent relapses, patient, and spouse had been explained regarding the nature of illness, and its several remedy modalities out there such as DSF. Written informed consent for DSF therapy was taken and also a dose of 500 mg/day was initiated. Patient was discharged with DSF (500 mg/day), and multivitamin supplementation. At discharge, his vital parameters had been steady with pulse of 86 beats/min, and BP of 130/80 mm of Hg. Compliance with drugs was ensured and supervised by his spouse. A fortnight later, patient complained of gradual onset occipital headache and giddiness with pulse price of 86 bpm and BP of 146/100 mm of Hg. Life style modifications and dietary measures along with above prescribed medicines had been advised. On week4 of DSF therapy, his complaints of headache, giddiness worsened, and BP elevated to 170/110 mm of Hg. In view of recent inclusion of DSF, with the absence of prior health-related illnesses or drug history contributing to hypertension, possibility of drug induced (DSF) hypertension was suspected. Subsequently, DSF was reduced to 250 mg/ day and BP lowered to 150/96 mm of Hg per week later. DSF was additional reduced to 125 mg/day following this observation and antihypertensive agents like telmisartan 40 mg and hydrochlorothiazide 12.5 mg/daywere also initiated on the physician’s tips. A month later (week8), patient reported with enhanced giddiness and physical fatigue with BP of 90/60 mm of Hg in spite of abstinent. Antihypertensive agents had been withdrawn and DSF was discontinued completely. Fortnight later (week10), patient had reached his premorbid levels of BP to 110/70 mm of Hg. Psycho education about medical illness, life style modifications for example normal exercises and dietary measures had been advised. Six months later, patient had maintained full abstinence from alcohol as well as tobacco, and his BP was 130/80 mm of Hg [Figure 1].DISCuSSIONDSF, an alcohol deterring agent which is relatively cIAP-1 Antagonist drug nontoxic substance when administered alone, markedly alters the intermediary metabolism of alcohol. It acts by inhibiting aldehyde dehydrogenase, alcohol dehydrogenase and dopamine betahydroxylase (DBH).[9] DSF in conjunction with its two metabolites, diethyldithiocarbamate, and carbon disulphide inhibit DBH activity, a norepinephrine (NE) biosynthetic enzyme, which typically catalyzes the formation of NE from dopamin.