Product Name :
PQR626
Description:
PQR626, a rapamycin derivative, is a potent, selective, orally active, and brain-penetrant mTOR inhibitor, with an IC50 and Ki of 5 nM and 3.6 nM, respectively. PQR626 can be can be used for the research of neurological disorders.
CAS:
1927857-98-4
Molecular Weight:
435.47
Formula:
C20H27F2N7O2
Chemical Name:
4-(difluoromethyl)-5-{4-[(3R, 5S)-3, 5-dimethylmorpholin-4-yl]-6-[(3R)-3-methylmorpholin-4-yl]-1, 3, 5-triazin-2-yl}pyridin-2-amine
Smiles :
C[C@@H]1COCCN1C1=NC(=NC(=N1)C1=CN=C(N)C=C1C(F)F)N1[C@H](C)COC[C@@H]1C
InChiKey:
YXQKBQLVKBUCLZ-UPJWGTAASA-N
InChi :
InChI=1S/C20H27F2N7O2/c1-11-8-30-5-4-28(11)19-25-18(15-7-24-16(23)6-14(15)17(21)22)26-20(27-19)29-12(2)9-31-10-13(29)3/h6-7,11-13,17H,4-5,8-10H2,1-3H3,(H2,23,24)/t11-,12-,13+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PQR626, a rapamycin derivative, is a potent, selective, orally active, and brain-penetrant mTOR inhibitor, with an IC50 and Ki of 5 nM and 3.6 nM, respectively. PQR626 can be can be used for the research of neurological disorders.|Product information|CAS Number: 1927857-98-4|Molecular Weight: 435.47|Formula: C20H27F2N7O2|Chemical Name: 4-(difluoromethyl)-5-{4-[(3R, 5S)-3, 5-dimethylmorpholin-4-yl]-6-[(3R)-3-methylmorpholin-4-yl]-1, 3, 5-triazin-2-yl}pyridin-2-amine|Smiles: C[C@@H]1COCCN1C1=NC(=NC(=N1)C1=CN=C(N)C=C1C(F)F)N1[C@H](C)COC[C@@H]1C|InChiKey: YXQKBQLVKBUCLZ-UPJWGTAASA-N|InChi: InChI=1S/C20H27F2N7O2/c1-11-8-30-5-4-28(11)19-25-18(15-7-24-16(23)6-14(15)17(21)22)26-20(27-19)29-12(2)9-31-10-13(29)3/h6-7,11-13,17H,4-5,8-10H2,1-3H3,(H2,23,24)/t11-,12-,13+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (229.{{Protease Inhibitor Cocktail} medchemexpress|{Protease Inhibitor Cocktail} NF-κB|{Protease Inhibitor Cocktail} Biological Activity|{Protease Inhibitor Cocktail} Purity|{Protease Inhibitor Cocktail} custom synthesis} 64 mM; Need ultrasonic).{{Pantoprazole} medchemexpress|{Pantoprazole} Anti-infection|{Pantoprazole} Technical Information|{Pantoprazole} In Vitro|{Pantoprazole} supplier|{Pantoprazole} Cancer} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24360118 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PQR626 (0.04-5 μΜ; 1 hour) has IC50s of 197 nM and 87 nM for pPKB S473 and pS6 S235/S236, respectively, in-cell western blot. S6 kinase (S6K), S6 ribosomal protein (S6rP) and 4E-binding protein (4E-BP) are prominent downstream effectors of mTOR.|In Vivo:|PQR626 (10-50 mg/kg; twice a day; for 90 days) reduces the loss of Tsc1-induced mortality as compared to vehicle. PQR626 exhibits terminal elimination half-life (mice 3.0 h) due to high plasma clearance (1096 ng/mL) following oral dosing (10 mg/kg; p.o.; daily; for 4 days).|Products are for research use only. Not for human use.|