Binovitch M Molecular pathogenesis of pulmonary arterial hypertension. J Clin Invest 118: 23722379. three. Kubo K, Hanaoka M, Hayano T, Miyahara T, Hachiya T, et al. Inflammatory cytokines in BAL fluid and pulmonary hemodynamics in highaltitude pulmonary edema. Respiration Physiology 111: 301310. 4. Tsai BM, Wang M, Pitcher JM, Meldrum KK, Meldrum DR Hypoxic pulmonary vasoconstriction and pulmonary artery tissue cytokine expression are mediated by protein kinase C. Am J Physiol Lung Cell Mol Physiol 287: L1215 1219. 5. Crouch EC, Parks WC, Rosenbaum JL, Chang D, Whitehouse L, et al. Regulation of order AN 3199 collagen production by medial smooth muscle cells in hypoxic pulmonary hypertension. American Assessment of Respiratory Illness 140: 1045 1051. six. Durmowicz AG, Parks WC, Hyde DM, Mecham RP, Stenmark KR Persistence, re-expression, and induction of pulmonary arterial fibronectin, tropoelastin, and sort I procollagen mRNA expression in neonatal hypoxic pulmonary hypertension. Am J Pathol 145: 14111420. 7. Wang DZ, Li S, CP21 chemical information Hockemeyer D, Sutherland L, Wang Z, et al. Potentiation of serum response issue activity by a family members of myocardin-related transcription factors. Proc Natl Acad Sci U S A 99: 1485514860. eight. Cen B, Selvaraj A, Burgess RC, Hitzler JK, Ma Z, et al. Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response element, is necessary for serum induction of SRF target genes. Mol Cell Biol 23: 6597 6608. 9. Smaller EM, Thatcher JE, Sutherland LB, Kinoshita H, Gerard RD, et al. Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial 
infarction. Circ Res 107: 294304. ten. Kuwahara K, Kinoshita H, Kuwabara Y, Nakagawa Y, Usami S, et al. Myocardin-related transcription aspect A is often a popular mediator of mechanical stress- and neurohumoral stimulation-induced cardiac hypertrophic signaling top to activation of brain natriuretic peptide gene expression. Mol Cell Biol 30: 41344148. 11. Fang F, Yang Y, Yuan Z, Gao Y, Zhou J, et al. Myocardin-related transcription element A mediates OxLDL-induced endothelial injury. Circ Res 108: 797807. 12. Xia J, Wu X, Yang Y, Zhao Y, Fang M, et al. SIRT1 deacetylates RFX5 and antagonizes repression of collagen kind I transcription in smooth muscle cells. Biochem Biophys Res Commun 428: 264270. 13. Fang M, Kong X, Li P, Fang F, Wu X, et al. RFXB and its splice variant RFXBSV mediate 
the antagonism between IFNgamma and TGFbeta on COL1A2 transcription in vascular smooth muscle cells. Nucleic Acids Res 37: 43934406. 14. Lee SM, Vasishtha M, Prywes R Activation and repression of cellular instant early genes by serum response factor cofactors. J Biol Chem 285: 2203622049. 15. Ko EA, Song MY, Donthamsetty R, Makino A, Yuan JX Tension Measurement in Isolated Rat and Mouse Pulmonary Artery. Drug Discov These days Dis Models 7: 123130. 16. Prie S, Leung TK, Cernacek P, Ryan JW, Dupuis J The orally active ET receptor antagonist –2–3-methoxy-3,3-diphe nyl-propionic acid prevents the improvement of pulmonary hypertension and endothelial metabolic dysfunction in monocrotaline-treated rats. J Pharmacol Exp Ther 282: 13121318. 17. Tian W, Xu H, Fang F, Chen 1313429 Q, Xu Y, et al. Brahma related gene 1 bridges epigenetic regulation of pro-inflammatory cytokine production to steatohepatitis. Hepatology. 18. Kong X, Fang M, Fang F, Li P, Xu Y PPARgamma enhances IFNgamma-mediated transcription and rescues the TGFbeta antagonism by stimulating CIITA in vascular smooth mus.Binovitch M Molecular pathogenesis of pulmonary arterial hypertension. J Clin Invest 118: 23722379. 3. Kubo K, Hanaoka M, Hayano T, Miyahara T, Hachiya T, et al. Inflammatory cytokines in BAL fluid and pulmonary hemodynamics in highaltitude pulmonary edema. Respiration Physiology 111: 301310. 4. Tsai BM, Wang M, Pitcher JM, Meldrum KK, Meldrum DR Hypoxic pulmonary vasoconstriction and pulmonary artery tissue cytokine expression are mediated by protein kinase C. Am J Physiol Lung Cell Mol Physiol 287: L1215 1219. 5. Crouch EC, Parks WC, Rosenbaum JL, Chang D, Whitehouse L, et al. Regulation of collagen production by medial smooth muscle cells in hypoxic pulmonary hypertension. American Overview of Respiratory Illness 140: 1045 1051. six. Durmowicz AG, Parks WC, Hyde DM, Mecham RP, Stenmark KR Persistence, re-expression, and induction of pulmonary arterial fibronectin, tropoelastin, and variety I procollagen mRNA expression in neonatal hypoxic pulmonary hypertension. Am J Pathol 145: 14111420. 7. Wang DZ, Li S, Hockemeyer D, Sutherland L, Wang Z, et al. Potentiation of serum response factor activity by a family members of myocardin-related transcription aspects. Proc Natl Acad Sci U S A 99: 1485514860. 8. Cen B, Selvaraj A, Burgess RC, Hitzler JK, Ma Z, et al. Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response element, is essential for serum induction of SRF target genes. Mol Cell Biol 23: 6597 6608. 9. Small EM, Thatcher JE, Sutherland LB, Kinoshita H, Gerard RD, et al. Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction. Circ Res 107: 294304. ten. Kuwahara K, Kinoshita H, Kuwabara Y, Nakagawa Y, Usami S, et al. Myocardin-related transcription issue A is a typical mediator of mechanical stress- and neurohumoral stimulation-induced cardiac hypertrophic signaling top to activation of brain natriuretic peptide gene expression. Mol Cell Biol 30: 41344148. 11. Fang F, Yang Y, Yuan Z, Gao Y, Zhou J, et al. Myocardin-related transcription issue A mediates OxLDL-induced endothelial injury. Circ Res 108: 797807. 12. Xia J, Wu X, Yang Y, Zhao Y, Fang M, et al. SIRT1 deacetylates RFX5 and antagonizes repression of collagen variety I transcription in smooth muscle cells. Biochem Biophys Res Commun 428: 264270. 13. Fang M, Kong X, Li P, Fang F, Wu X, et al. RFXB and its splice variant RFXBSV mediate the antagonism in between IFNgamma and TGFbeta on COL1A2 transcription in vascular smooth muscle cells. Nucleic Acids Res 37: 43934406. 14. Lee SM, Vasishtha M, Prywes R Activation and repression of cellular quick early genes by serum response aspect cofactors. J Biol Chem 285: 2203622049. 15. Ko EA, Song MY, Donthamsetty R, Makino A, Yuan JX Tension Measurement in Isolated Rat and Mouse Pulmonary Artery. Drug Discov These days Dis Models 7: 123130. 16. Prie S, Leung TK, Cernacek P, Ryan JW, Dupuis J The orally active ET receptor antagonist –2–3-methoxy-3,3-diphe nyl-propionic acid prevents the improvement of pulmonary hypertension and endothelial metabolic dysfunction in monocrotaline-treated rats. J Pharmacol Exp Ther 282: 13121318. 17. Tian W, Xu H, Fang F, Chen 1313429 Q, Xu Y, et al. Brahma associated gene 1 bridges epigenetic regulation of pro-inflammatory cytokine production to steatohepatitis. Hepatology. 18. Kong X, Fang M, Fang F, Li P, Xu Y PPARgamma enhances IFNgamma-mediated transcription and rescues the TGFbeta antagonism by stimulating CIITA in vascular smooth mus.