To this conclude, we executed a detailed examination of canonical Wnt signaling factors at the mRNA and protein amount, assessing expression, localization, as well as activity of Wnt ligands, receptors, and intracellular signaling molecules in IPF
Next, we analyzed the expression of the wellcharacterized Wnt focus on genes fibronectin (Fn) one, matrix metalloproteinase (Mmp) seven, and cyclin D1 in IPF lungs. As depicted in Figure 7b,…