Product Name :
JNJ0966
Description:
JNJ0966 is a highly selective compound that inhibits activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme. It has no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity and did not inhibit activation of the highly related MMP-2 zymogen.
CAS:
315705-75-0
Molecular Weight:
360.45
Formula:
C16H16N4O2S2
Chemical Name:
N-(5-2-[(2-methoxyphenyl)amino]-1,3-thiazol-4-yl-4-methyl-1,3-thiazol-2-yl)acetamide
Smiles :
CC1N=C(NC(C)=O)SC=1C1=CSC(NC2=CC=CC=C2OC)=N1
InChiKey:
ZADCDCMLLGDCRM-UHFFFAOYSA-N
InChi :
InChI=1S/C16H16N4O2S2/c1-9-14(24-16(17-9)18-10(2)21)12-8-23-15(20-12)19-11-6-4-5-7-13(11)22-3/h4-8H,1-3H3,(H,19,20)(H,17,18,21)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Cabazitaxel Purity & Documentation
Shelf Life:
≥12 months if stored properly.Colistin Autophagy
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
JNJ0966 is a highly selective compound that inhibits activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme. It has no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity and did not inhibit activation of the highly related MMP-2 zymogen.|Product information|CAS Number: 315705-75-0|Molecular Weight: 360.45|Formula: C16H16N4O2S2|Chemical Name: N-(5-2-[(2-methoxyphenyl)amino]-1,3-thiazol-4-yl-4-methyl-1,3-thiazol-2-yl)acetamide|Smiles: CC1N=C(NC(C)=O)SC=1C1=CSC(NC2=CC=CC=C2OC)=N1|InChiKey: ZADCDCMLLGDCRM-UHFFFAOYSA-N|InChi: InChI=1S/C16H16N4O2S2/c1-9-14(24-16(17-9)18-10(2)21)12-8-23-15(20-12)19-11-6-4-5-7-13(11)22-3/h4-8H,1-3H3,(H,19,20)(H,17,18,21)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Solubility (25°C).PMID:32415775 72 mg/mL(199.75 mM). Insoluble.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|JNJ0966 inhibits the conversion of proMMP-9 to active MMP-9 but is not a direct inhibitor of MMP-9 or MMP-3 enzymatic activity. JNJ0966 inhibits proMMP-9 maturation.|In Vivo:|Oral administration of JNJ0966 significantly diminishes the clinical disease score observed in the mouse EAE model.|Products are for research use only. Not for human use.|