Tables Milk thistle seeds Flavonoid aglycone in fruits and vegetables Grape skin and seeds Withania somnifera Biological Activity Anti-proliferative Apoptosis Apoptosis Anti-proliferative Apoptosis Apoptosis Anti-proliferative Apoptosis Apoptosis Anti-proliferative Ref. [70] [71] [56] [72] [73] [74] [75] [76] [77] [78]ColorectalAnti-proliferative[79]Corilagin Gallic acid Ellagic acid Epigallocatechin-3-gallate Ovarian BerberineAnti-proliferative Apoptosis Anti-proliferative Apoptosis Apoptosis/Antiproliferative[80] [81] [82] [83][84]Rosavin Oleanolic acid Silibinin Blood Kaempferol Resveratrol Withaferin AApoptosis Antiangiogenic Antiangiogenic Antiangiogenic Antiangiogenic Antiangiogenic[85] [86] [87] [88] [89] [90]Bergamot (Citrus bergamia Risso et Poiteau) is a citrus fruit developing almost exclusively inside the south of Italy inside a restricted region of the Calabrian coast, due to the specific environmental conditions which can be favorable for its cultivation. This citrus fruit is defined as a hybrid amongst a sour orange (C. aurantium L.) and lemon (C. limon L.) or in between a sour orange and lime. Bergamot possesses a distinctive profile of flavonoids and flavonoid glycosides [91]. To date, several significant properties are recognized in bergamot, such as antioxidant, anti-inflammatory [927], neuroprotective, hypoglycemic, and hypolipemic properties against quite a few metabolic ailments [9800]. Bergamot fruit is mostly made use of for its important oil (BEO), obtained by rasping the fruit peel, its polyphenolic fraction (BPF), and its juice (BJ), which can be obtained by squeezing the fruits and was initially considered as a secondary item. Olive oil is one of the primary constituents of the Mediterranean diet program and is extracted from olive drupes that contain identified biophenol secoiridoids. Among these, among the most beneficial identified is oleuropein, which was proven to possess numerous helpful properties like antioxidant, anti-inflammatory, anticancer, antiviral, hypoglycemic, neuroprotective, and antiaging effects [10103]. Because of this, this natural compound is regarded as to be a “super functional food”. Turmeric (Curcuma Longa) can be a plant belonging for the ginger family members (Zingiberaceae), native to India but present also in China, Southeast Asia, and Latin America. Turmeric isNutrients 2021, 13,7 ofa prevalent spice, but in recent decades has aroused scientific interest for its therapeutic prospective with anticancer, anti-inflammatory, antidiabetic, antiaging, and neuroregenerative effects [10406]. Curcumin, a yellow pigment from Curcuma longa, could be the main element of turmeric, and chemically it’s a poliphenol. Quercetin can be a flavonoid ubiquitously present in fruits and vegetables, and because of this its intake is very typical within the Mediterranean eating plan. It has also been recognized that quercetin performs many beneficial functions by YTX-465 Biological Activity acting as an antioxidant, anticarcinogenic, anti-inflammatory, antidiabetic, and antimicrobial [107,108]. Quercetin demonstrates dose-dependent effects: at low concentrations, it acts as an antioxidant, although at higher concentrations, it’s a pro-oxidant compound [109]. Presently, know-how and encounter regarding the anticancer activity of organic compounds is growing. Since the remedy of cancer having a recognized chemotherapy Cholesteryl sulfate MedChemExpress induces the onset of systemic negative effects, which include cardiotoxicity or nephrotoxicity, which often demand the early withdrawal or replacement of therapy, the use of all-natural compounds as adjuvants of che.