Product Name :
Jervine
Description:
Jervine (11-Ketocyclopamine) is a Hedgehog signaling (IC50=500-700 nM) inhibitor that inhibits the sonic hedgehog (shh) pathway by interacting with smoothened.
CAS:
469-59-0
Molecular Weight:
425.60
Formula:
C27H39NO3
Chemical Name:
(3S,3’R,3’aS,6’S,6aS,6bS,7’aR,9R,11aS,11bR)-3-hydroxy-3′,6′,10,11b-tetramethyl-1,2,3,3’a,4,4′,5′,6,6′,6a,6b,7,7′,7’a,8,11,11a,11b-octadecahydro-3’H-spiro[cyclohexa[a]fluorene-9,2′-furo[3,2-b]pyridin]-11-one
Smiles :
C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2C(=O)C2[C@H]1CC[C@]1(O[C@@H]3C[C@H](C)CN[C@H]3[C@H]1C)C=2C
InChiKey:
CLEXYFLHGFJONT-DNMILWOZSA-N
InChi :
InChI=1S/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3/t14-,16+,18-,19-,20-,21+,23+,24-,26-,27-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Lasalocid Parasite
Shelf Life:
≥12 months if stored properly.EN4 Apoptosis
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33084512
Additional information:
Jervine (11-Ketocyclopamine) is a Hedgehog signaling (IC50=500-700 nM) inhibitor that inhibits the sonic hedgehog (shh) pathway by interacting with smoothened.|Product information|CAS Number: 469-59-0|Molecular Weight: 425.60|Formula: C27H39NO3|Synonym:|11-Ketocyclopamine|Chemical Name: (3S,3’R,3’aS,6’S,6aS,6bS,7’aR,9R,11aS,11bR)-3-hydroxy-3′,6′,10,11b-tetramethyl-1,2,3,3’a,4,4′,5′,6,6′,6a,6b,7,7′,7’a,8,11,11a,11b-octadecahydro-3’H-spiro[cyclohexa[a]fluorene-9,2′-furo[3,2-b]pyridin]-11-one|Smiles: C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2C(=O)C2[C@H]1CC[C@]1(O[C@@H]3C[C@H](C)CN[C@H]3[C@H]1C)C=2C|InChiKey: CLEXYFLHGFJONT-DNMILWOZSA-N|InChi: InChI=1S/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3/t14-,16+,18-,19-,20-,21+,23+,24-,26-,27-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|