Product Name :
Ambroxol hydrochloride
Description:
Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the prodrug Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.
CAS:
23828-92-4
Molecular Weight:
414.56
Formula:
C13H19Br2ClN2O
Chemical Name:
4-{[(2-amino-3,5-dibromophenyl)methyl]amino}cyclohexan-1-ol hydrochloride
Smiles :
Cl.NC1C(CNC2CCC(O)CC2)=CC(Br)=CC=1Br
InChiKey:
QNVKOSLOVOTXKF-UHFFFAOYSA-N
InChi :
InChI=1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Acacetin} medchemexpress|{Acacetin} Apoptosis|{Acacetin} Purity & Documentation|{Acacetin} Data Sheet|{Acacetin} custom synthesis|{Acacetin} Cancer}
Shelf Life:
≥12 months if stored properly.{{Concizumab} medchemexpress|{Concizumab} Protocol|{Concizumab} Description|{Concizumab} supplier|{Concizumab} Epigenetic Reader Domain}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:26644518
Additional information:
Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the prodrug Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.|Product information|CAS Number: 23828-92-4|Molecular Weight: 414.56|Formula: C13H19Br2ClN2O|Chemical Name: 4-{[(2-amino-3,5-dibromophenyl)methyl]amino}cyclohexan-1-ol hydrochloride|Smiles: Cl.NC1C(CNC2CCC(O)CC2)=CC(Br)=CC=1Br|InChiKey: QNVKOSLOVOTXKF-UHFFFAOYSA-N|InChi: InChI=1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : 8.33 mg/mL (20.09 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Ambroxol hydrochloride (NA-872 hydrochloride; 1, 3, 4, 5 mM for 12 consecutive days in drinking water) results in increased brain glucocerebrosidase activity in wild-type mice, transgenic mice expressing the heterozygous L444P mutation in the murine glucocerebrosidase 1 gene, and transgenic mice overexpressing human α-synuclein.|Products are for research use only. Not for human use.|