les 2021, 26, 5914. doi.org/10.3390/molecules 26195914 Academic Editors: Baojun Xu and Kumar Ganesan Received: 11 August 2021 Accepted: three September 2021 Published: 29 SeptemberAbstract: All-natural solutions happen to be used by humanity for a lot of centuries to treat several illnesses and using the advancement of technologies, it became attainable to isolate the substances responsible for the valuable effects of those merchandise, too as to understand their mechanisms. In this context, myristicin, a substance of all-natural origin, has shown several promising activities in a massive number of in vitro and in vivo research carried out. This molecule is discovered in plants including nutmeg, parsley, carrots, peppers, and quite a few species endemic towards the Asian continent. The objective of this assessment short article will be to discuss information published in the last 10 years at Pubmed, Lilacs and Scielo databases, reporting helpful effects, toxicity and promising data of myristicin for its future use in medicine. From 94 articles identified in the literature, 68 were included. Exclusion criteria took into account articles whose tested extracts didn’t have myristicin as certainly one of the important compounds. Key phrases: myristicin; nutmeg; all-natural products; bioactive compounds; therapeutic properties1. PDE10 Synonyms Introduction Biodiversity may be the variability of all living beings in the biosphere, in its entirety. Such beings become renewable sources of substances which will originate many solutions for human consumption, like medicines for the remedy of a variety of pathologies. The key producers of those substances are plants, microorganisms, marine algae, among other people, which over a huge number of years of evolution, have been capable of adaptations that created them capable of acquiring biological activities of several kinds [1]. Information show that you’ll find still handful of drug discovery applications based on organic solutions in pharmaceutical companies, even though they may be a promising supply of new drugs [2]. Even so, drugs made from all-natural substances are various, given that those obtained from organic sources represent about 70 of all drugs authorized for therapeutic use inside the final 4 decades [3]. Natural compounds have already been among the principle sources of the production of medicines since the starting of time, providing rise to drugs of distinct therapeutic classes. One of the main examples may be the discovery of penicillin in 1928, by the researcher Alexander Fleming, whose analysis with fungi of the Penicillium genus culminated within the discovery of a compound with an antibacterial activity. This compound was called penicillin and is presently applied to treat infections triggered by bacteria from the Staphylococcus genus [4]. An additional organic compound of excellent significance is quinine, NOX2 list derived in the bark in the quinine. Initially this herb was consumed by the indigenous people from the Amazon region. This plant has been used for decades to treat malaria, and this substance gave rise to other drugsPublisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.Copyright: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is definitely an open access short article distributed beneath the terms and circumstances with the Inventive Commons Attribution (CC BY) license ( creativecommons.org/licenses/by/ 4.0/).Molecules 2021, 26, 5914. doi.org/10.3390/moleculesmdpi/journal/moleculesMolecules 2021, 26,2 ofto treat the disease, such as chloroquine [2]. Arnica montana plant species, also extensively made use of in Br